Can exercise training reduce central systolic blood pressure among patients with resistant hypertension?
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.34624/jshd.v4i1.29005 |
Resumo: | Introduction: Resistant hypertension is a problematic phenotype marked by the limited efficacy of available blood pressure-lowering treatments [1], such as antihypertensive medicines and kidney denervation [2-4]. Given its economic and health-related impact, it is a major medical and societal concern. Patients with resistant hypertension have a higher risk of myocardial infarction, stroke, heart failure, chronic renal disease, and death, in addition to the cost of multiple drugs [5,6]. Cardiovascular disease risk is associated to central blood pressure. Central blood pressure has been evocated as being more closely related with target organ damage and long-term cardiovascular outcomes than traditional brachial blood pressure [7,8]. Increased aortic stiffness, assessed by carotid-femoral pulse wave velocity, is also an independent predictor of cardiovascular risk [9]. However, there are few studies on exercise interventions to improve these markers in people with resistant hypertension. The EnRicH (The Exercise Training in the Treatment of Resistant Hypertension) was a prospective, single-blinded randomized clinical trial. The current analysis details the effect of aerobic exercise training intervention or usual care on central blood pressure and carotid–femoral pulse wave velocity. Methods: Patients with resistant hypertension were randomized 1:1 to a 12-week moderate-intensity aerobic exercise program (added to usual care) or usual care. Exercise training sessions were supervised and took place three times per week. Each session included a 10-min warm-up and cool-down period, and 40 minutes of aerobic exercise. Walking and cycling were the main chosen exercises and intensity was 50-70% of maximum oxygen uptake (VO2 max). Secondary outcome measures included central blood pressure and carotid–femoral pulse wave velocity. The Complior Analyse (Alam Medical, Saint Quentin Fallavier, France) and the SphygmoCor (AtCor Medical, Sydney, NSW, Australia) were used to measure central blood pressure and carotid–femoral pulse wave velocity. The two devices offer highly correlated measurements and similar outcomes. The carotid–femoral pulse wave velocity measurements were taken in accordance with Van Bortel et al. (2012) expert's consensus document. SPSS version 28.0 was used for all statistical analyses (SPSS Inc., Chicago, Illinois, USA). Student's independent t-test was used to compare between-group differences at baseline, following the exercise program, and between changes in continuous variables from baseline to the end of the study. Student’s paired t-tests were performed for within-group comparisons from baseline to the end of the study. The level of significance was set as P ≤ 0.05. Results: Fifty-three patients (exercise n = 26, mean age 59.3 ± 8.2; control n = 27, mean age 60.8 ± 9.2) completed the study. No differences were found between groups at baseline. The change in central systolic blood pressure was significantly different between groups by -12.22 (95% CI, -1.88 to -22.57, P = 0.022), with a mean change of -11.3 ± 19.2 mm Hg in the exercise arm vs 0.9 ± 11.8 mm Hg in the control arm. There were no differences in carotid–femoral pulse wave velocity between groups (P = 0.197). Discussion: This study demonstrated that a12-week exercise training program reduces central blood pressure among patients with resistant hypertension. Our study agrees with previous evidence in patients with prehypertension and hypertension [10,11]. A limitation of this study is that exercise training program consisted of moderate-intensity aerobic exercises. Therefore, other exercise intensities and types of exercise need investigation. This trial demonstrated a benefit of 12-week of moderate-intensity aerobic exercise training on reducing central blood pressure in patients with resistant hypertension. The central blood pressure reduction is clinically promising as theis indicator is associated with target organ damage, cardiovascular risk, and mortality. Ethics committee and informed consent: All patients provided written informed consent. The study was approved by the Ethics Committee of the Centro Hospitalar do Baixo Vouga Clinical study registration number: NCT03090529 Acknowledgements: This work was funded by the European Union through the European Regional Development Fund Operational Competitiveness Factors Program (COMPETE) and by the Portuguese government through the Foundation for Science and Technology (grants P2020-PTDC/DTP-DES/1725/2014 and POCI-01-0145-FEDER-016710). Susana Lopes was awarded with a Portuguese Foundation for Science and Technology PhD grant (grant SFRH/ BD/129454/2017). Institute of Biomedicine (iBiMED; reference No. UID/BIM/04501/2020), Research Centre in Physical Activity, Health and Leisure (CIAFEL; reference No. UID/DTP/00617/ 2020), and Research Center in Sports Sciences, Health and Human Development (CIDESD; reference No. UID/DTP/ 04045/2020) are research units supported by the Portuguese Foundation for Science and Technology. Cátia Leitão is grateful to FCT for the research contract CEECIND/00154/2020 and the projects UIDB/50025/2020, UIDP/50025/2020 and LA/P/0037/2020, financed by national funds through the FCT/MEC. References: 1. Carey RM, Calhoun DA, Bakris GL, Brook RD, Daugherty SL, Dennison-Himmelfarb CR, et al. Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association. Hypertension. 2018;72(5):e53-e90. Epub 2018/10/26. doi: 10.1161/HYP.0000000000000084. PubMed PMID: 30354828; PubMed Central PMCID: PMCPMC6530990. Bakris GL, Townsend RR, Liu M, Cohen SA, D'Agostino R, Flack JM, et al. Impact of renal denervation on 24-hour ambulatory blood pressure: results from SYMPLICITY HTN-3. Journal of the American College of Cardiology. 2014;64(11):1071-8. Epub 2014/05/27. doi: 10.1016/j.jacc.2014.05.012. PubMed PMID: 24858423. Agasthi P, Shipman J, Arsanjani R, Ashukem M, Girardo ME, Yerasi C, et al. Renal Denervation for Resistant Hypertension in the contemporary era: A Systematic Review and Meta-analysis. Sci Rep. 2019;9(1):6200. Epub 2019/04/19. doi: 10.1038/s41598-019-42695-9. PubMed PMID: 30996305; PubMed Central PMCID: PMCPMC6470219. Bhatt DL, Kandzari DE, O'Neill WW, D'Agostino R, Flack JM, Katzen BT, et al. A controlled trial of renal denervation for resistant hypertension. The New England journal of medicine. 2014;370(15):1393-401. Epub 2014/04/01. doi: 10.1056/NEJMoa1402670. PubMed PMID: 24678939. Daugherty SL, Powers JD, Magid DJ, Tavel HM, Masoudi FA, Margolis KL, et al. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation. 2012;125(13):1635-42. doi: 10.1161/CIRCULATIONAHA.111.068064. PubMed PMID: 22379110; PubMed Central PMCID: PMCPMC3343635. Sapoval M, Hale BC, Armstrong S, Da Deppo L, Hertz D, Briggs A. The Burden of Resistant Hypertension in 5 European Countries. Value in Health. 2013;16:A520-A1. doi: 10.1016/j.jval.2013.08.1252. Kollias A, Lagou S, Zeniodi ME, Boubouchairopoulou N, Stergiou GS. Association of Central Versus Brachial Blood Pressure With Target-Organ Damage: Systematic Review and Meta-Analysis. Hypertension. 2016;67(1):183-90. Epub 2015/11/26. doi: 10.1161/HYPERTENSIONAHA.115.06066. PubMed PMID: 26597821. Vlachopoulos C, Aznaouridis K, O'Rourke MF, Safar ME, Baou K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis. European heart journal. 2010;31(15):1865-71. Epub 2010/03/04. doi: 10.1093/eurheartj/ehq024. PubMed PMID: 20197424. Cardoso CRL, Salles GF. Prognostic Value of Changes in Aortic Stiffness for Cardiovascular Outcomes and Mortality in Resistant Hypertension: a Cohort Study. Hypertension. 2022;79(2):447-56. Epub 2022/01/13. doi: 10.1161/HYPERTENSIONAHA.121.18498. PubMed PMID: 35020459. Beck DT, Martin JS, Casey DP, Braith RW. Exercise Training Reduces Peripheral Arterial Stiffness and Myocardial Oxygen Demand in Young Prehypertensive Subjects. American Journal of Hypertension. 2013;26:1093-102. doi: 10.1093/ajh/hpt080. Nualnim N, Parkhurst K, Dhindsa M, Tarumi T, Vavrek J, Tanaka H. Effects of Swimming Training on Blood Pressure and Vascular Function in Adults > 50 Years of Age. AMERICAN JOURNAL OF CARDIOLOGY. 2012;109:1005-10. doi: 10.1016/j.amjcard.2011.11.029. Figures captions/legends: Figure 1. Change from baseline to the end of treatment in central blood pressure and carotid-femoral pulse wave velocity in both study groups. |
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Can exercise training reduce central systolic blood pressure among patients with resistant hypertension?Introduction: Resistant hypertension is a problematic phenotype marked by the limited efficacy of available blood pressure-lowering treatments [1], such as antihypertensive medicines and kidney denervation [2-4]. Given its economic and health-related impact, it is a major medical and societal concern. Patients with resistant hypertension have a higher risk of myocardial infarction, stroke, heart failure, chronic renal disease, and death, in addition to the cost of multiple drugs [5,6]. Cardiovascular disease risk is associated to central blood pressure. Central blood pressure has been evocated as being more closely related with target organ damage and long-term cardiovascular outcomes than traditional brachial blood pressure [7,8]. Increased aortic stiffness, assessed by carotid-femoral pulse wave velocity, is also an independent predictor of cardiovascular risk [9]. However, there are few studies on exercise interventions to improve these markers in people with resistant hypertension. The EnRicH (The Exercise Training in the Treatment of Resistant Hypertension) was a prospective, single-blinded randomized clinical trial. The current analysis details the effect of aerobic exercise training intervention or usual care on central blood pressure and carotid–femoral pulse wave velocity. Methods: Patients with resistant hypertension were randomized 1:1 to a 12-week moderate-intensity aerobic exercise program (added to usual care) or usual care. Exercise training sessions were supervised and took place three times per week. Each session included a 10-min warm-up and cool-down period, and 40 minutes of aerobic exercise. Walking and cycling were the main chosen exercises and intensity was 50-70% of maximum oxygen uptake (VO2 max). Secondary outcome measures included central blood pressure and carotid–femoral pulse wave velocity. The Complior Analyse (Alam Medical, Saint Quentin Fallavier, France) and the SphygmoCor (AtCor Medical, Sydney, NSW, Australia) were used to measure central blood pressure and carotid–femoral pulse wave velocity. The two devices offer highly correlated measurements and similar outcomes. The carotid–femoral pulse wave velocity measurements were taken in accordance with Van Bortel et al. (2012) expert's consensus document. SPSS version 28.0 was used for all statistical analyses (SPSS Inc., Chicago, Illinois, USA). Student's independent t-test was used to compare between-group differences at baseline, following the exercise program, and between changes in continuous variables from baseline to the end of the study. Student’s paired t-tests were performed for within-group comparisons from baseline to the end of the study. The level of significance was set as P ≤ 0.05. Results: Fifty-three patients (exercise n = 26, mean age 59.3 ± 8.2; control n = 27, mean age 60.8 ± 9.2) completed the study. No differences were found between groups at baseline. The change in central systolic blood pressure was significantly different between groups by -12.22 (95% CI, -1.88 to -22.57, P = 0.022), with a mean change of -11.3 ± 19.2 mm Hg in the exercise arm vs 0.9 ± 11.8 mm Hg in the control arm. There were no differences in carotid–femoral pulse wave velocity between groups (P = 0.197). Discussion: This study demonstrated that a12-week exercise training program reduces central blood pressure among patients with resistant hypertension. Our study agrees with previous evidence in patients with prehypertension and hypertension [10,11]. A limitation of this study is that exercise training program consisted of moderate-intensity aerobic exercises. Therefore, other exercise intensities and types of exercise need investigation. This trial demonstrated a benefit of 12-week of moderate-intensity aerobic exercise training on reducing central blood pressure in patients with resistant hypertension. The central blood pressure reduction is clinically promising as theis indicator is associated with target organ damage, cardiovascular risk, and mortality. Ethics committee and informed consent: All patients provided written informed consent. The study was approved by the Ethics Committee of the Centro Hospitalar do Baixo Vouga Clinical study registration number: NCT03090529 Acknowledgements: This work was funded by the European Union through the European Regional Development Fund Operational Competitiveness Factors Program (COMPETE) and by the Portuguese government through the Foundation for Science and Technology (grants P2020-PTDC/DTP-DES/1725/2014 and POCI-01-0145-FEDER-016710). Susana Lopes was awarded with a Portuguese Foundation for Science and Technology PhD grant (grant SFRH/ BD/129454/2017). Institute of Biomedicine (iBiMED; reference No. UID/BIM/04501/2020), Research Centre in Physical Activity, Health and Leisure (CIAFEL; reference No. UID/DTP/00617/ 2020), and Research Center in Sports Sciences, Health and Human Development (CIDESD; reference No. UID/DTP/ 04045/2020) are research units supported by the Portuguese Foundation for Science and Technology. Cátia Leitão is grateful to FCT for the research contract CEECIND/00154/2020 and the projects UIDB/50025/2020, UIDP/50025/2020 and LA/P/0037/2020, financed by national funds through the FCT/MEC. References: 1. Carey RM, Calhoun DA, Bakris GL, Brook RD, Daugherty SL, Dennison-Himmelfarb CR, et al. Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association. Hypertension. 2018;72(5):e53-e90. Epub 2018/10/26. doi: 10.1161/HYP.0000000000000084. PubMed PMID: 30354828; PubMed Central PMCID: PMCPMC6530990. Bakris GL, Townsend RR, Liu M, Cohen SA, D'Agostino R, Flack JM, et al. Impact of renal denervation on 24-hour ambulatory blood pressure: results from SYMPLICITY HTN-3. Journal of the American College of Cardiology. 2014;64(11):1071-8. Epub 2014/05/27. doi: 10.1016/j.jacc.2014.05.012. PubMed PMID: 24858423. Agasthi P, Shipman J, Arsanjani R, Ashukem M, Girardo ME, Yerasi C, et al. Renal Denervation for Resistant Hypertension in the contemporary era: A Systematic Review and Meta-analysis. Sci Rep. 2019;9(1):6200. Epub 2019/04/19. doi: 10.1038/s41598-019-42695-9. PubMed PMID: 30996305; PubMed Central PMCID: PMCPMC6470219. Bhatt DL, Kandzari DE, O'Neill WW, D'Agostino R, Flack JM, Katzen BT, et al. A controlled trial of renal denervation for resistant hypertension. The New England journal of medicine. 2014;370(15):1393-401. Epub 2014/04/01. doi: 10.1056/NEJMoa1402670. PubMed PMID: 24678939. Daugherty SL, Powers JD, Magid DJ, Tavel HM, Masoudi FA, Margolis KL, et al. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation. 2012;125(13):1635-42. doi: 10.1161/CIRCULATIONAHA.111.068064. PubMed PMID: 22379110; PubMed Central PMCID: PMCPMC3343635. Sapoval M, Hale BC, Armstrong S, Da Deppo L, Hertz D, Briggs A. The Burden of Resistant Hypertension in 5 European Countries. Value in Health. 2013;16:A520-A1. doi: 10.1016/j.jval.2013.08.1252. Kollias A, Lagou S, Zeniodi ME, Boubouchairopoulou N, Stergiou GS. Association of Central Versus Brachial Blood Pressure With Target-Organ Damage: Systematic Review and Meta-Analysis. Hypertension. 2016;67(1):183-90. Epub 2015/11/26. doi: 10.1161/HYPERTENSIONAHA.115.06066. PubMed PMID: 26597821. Vlachopoulos C, Aznaouridis K, O'Rourke MF, Safar ME, Baou K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis. European heart journal. 2010;31(15):1865-71. Epub 2010/03/04. doi: 10.1093/eurheartj/ehq024. PubMed PMID: 20197424. Cardoso CRL, Salles GF. Prognostic Value of Changes in Aortic Stiffness for Cardiovascular Outcomes and Mortality in Resistant Hypertension: a Cohort Study. Hypertension. 2022;79(2):447-56. Epub 2022/01/13. doi: 10.1161/HYPERTENSIONAHA.121.18498. PubMed PMID: 35020459. Beck DT, Martin JS, Casey DP, Braith RW. Exercise Training Reduces Peripheral Arterial Stiffness and Myocardial Oxygen Demand in Young Prehypertensive Subjects. American Journal of Hypertension. 2013;26:1093-102. doi: 10.1093/ajh/hpt080. Nualnim N, Parkhurst K, Dhindsa M, Tarumi T, Vavrek J, Tanaka H. Effects of Swimming Training on Blood Pressure and Vascular Function in Adults > 50 Years of Age. AMERICAN JOURNAL OF CARDIOLOGY. 2012;109:1005-10. doi: 10.1016/j.amjcard.2011.11.029. Figures captions/legends: Figure 1. Change from baseline to the end of treatment in central blood pressure and carotid-femoral pulse wave velocity in both study groups. University of Aveiro (UA) and Hospital Center of Baixo Vouga (CHBV)2022-07-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.34624/jshd.v4i1.29005oai:proa.ua.pt:article/29005Journal of Statistics on Health Decision; Vol 4 No 1 (2022): Special Issue - Statistics on Health Decision Making: Real World Data; 73-75Journal of Statistics on Health Decision; vol. 4 n.º 1 (2022): Special Issue - Statistics on Health Decision Making: Real World Data; 73-752184-5794reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://proa.ua.pt/index.php/jshd/article/view/29005https://doi.org/10.34624/jshd.v4i1.29005https://proa.ua.pt/index.php/jshd/article/view/29005/20653Copyright (c) 2022 Susana Lopes, José Mesquita-Bastos, Cátia Leitão, Veronica Ribau, Catarina Garcia, José Oliveira, Jorge Polónia, Alberto Alves, Fernando Ribeirohttp://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessLopes, SusanaMesquita-Bastos, JoséLeitão, CátiaRibau, VeronicaGarcia, CatarinaOliveira, JoséPolónia, JorgeAlves, AlbertoRibeiro, Fernando2022-09-06T09:09:23Zoai:proa.ua.pt:article/29005Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:27:41.745713Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Can exercise training reduce central systolic blood pressure among patients with resistant hypertension? |
title |
Can exercise training reduce central systolic blood pressure among patients with resistant hypertension? |
spellingShingle |
Can exercise training reduce central systolic blood pressure among patients with resistant hypertension? Lopes, Susana |
title_short |
Can exercise training reduce central systolic blood pressure among patients with resistant hypertension? |
title_full |
Can exercise training reduce central systolic blood pressure among patients with resistant hypertension? |
title_fullStr |
Can exercise training reduce central systolic blood pressure among patients with resistant hypertension? |
title_full_unstemmed |
Can exercise training reduce central systolic blood pressure among patients with resistant hypertension? |
title_sort |
Can exercise training reduce central systolic blood pressure among patients with resistant hypertension? |
author |
Lopes, Susana |
author_facet |
Lopes, Susana Mesquita-Bastos, José Leitão, Cátia Ribau, Veronica Garcia, Catarina Oliveira, José Polónia, Jorge Alves, Alberto Ribeiro, Fernando |
author_role |
author |
author2 |
Mesquita-Bastos, José Leitão, Cátia Ribau, Veronica Garcia, Catarina Oliveira, José Polónia, Jorge Alves, Alberto Ribeiro, Fernando |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lopes, Susana Mesquita-Bastos, José Leitão, Cátia Ribau, Veronica Garcia, Catarina Oliveira, José Polónia, Jorge Alves, Alberto Ribeiro, Fernando |
description |
Introduction: Resistant hypertension is a problematic phenotype marked by the limited efficacy of available blood pressure-lowering treatments [1], such as antihypertensive medicines and kidney denervation [2-4]. Given its economic and health-related impact, it is a major medical and societal concern. Patients with resistant hypertension have a higher risk of myocardial infarction, stroke, heart failure, chronic renal disease, and death, in addition to the cost of multiple drugs [5,6]. Cardiovascular disease risk is associated to central blood pressure. Central blood pressure has been evocated as being more closely related with target organ damage and long-term cardiovascular outcomes than traditional brachial blood pressure [7,8]. Increased aortic stiffness, assessed by carotid-femoral pulse wave velocity, is also an independent predictor of cardiovascular risk [9]. However, there are few studies on exercise interventions to improve these markers in people with resistant hypertension. The EnRicH (The Exercise Training in the Treatment of Resistant Hypertension) was a prospective, single-blinded randomized clinical trial. The current analysis details the effect of aerobic exercise training intervention or usual care on central blood pressure and carotid–femoral pulse wave velocity. Methods: Patients with resistant hypertension were randomized 1:1 to a 12-week moderate-intensity aerobic exercise program (added to usual care) or usual care. Exercise training sessions were supervised and took place three times per week. Each session included a 10-min warm-up and cool-down period, and 40 minutes of aerobic exercise. Walking and cycling were the main chosen exercises and intensity was 50-70% of maximum oxygen uptake (VO2 max). Secondary outcome measures included central blood pressure and carotid–femoral pulse wave velocity. The Complior Analyse (Alam Medical, Saint Quentin Fallavier, France) and the SphygmoCor (AtCor Medical, Sydney, NSW, Australia) were used to measure central blood pressure and carotid–femoral pulse wave velocity. The two devices offer highly correlated measurements and similar outcomes. The carotid–femoral pulse wave velocity measurements were taken in accordance with Van Bortel et al. (2012) expert's consensus document. SPSS version 28.0 was used for all statistical analyses (SPSS Inc., Chicago, Illinois, USA). Student's independent t-test was used to compare between-group differences at baseline, following the exercise program, and between changes in continuous variables from baseline to the end of the study. Student’s paired t-tests were performed for within-group comparisons from baseline to the end of the study. The level of significance was set as P ≤ 0.05. Results: Fifty-three patients (exercise n = 26, mean age 59.3 ± 8.2; control n = 27, mean age 60.8 ± 9.2) completed the study. No differences were found between groups at baseline. The change in central systolic blood pressure was significantly different between groups by -12.22 (95% CI, -1.88 to -22.57, P = 0.022), with a mean change of -11.3 ± 19.2 mm Hg in the exercise arm vs 0.9 ± 11.8 mm Hg in the control arm. There were no differences in carotid–femoral pulse wave velocity between groups (P = 0.197). Discussion: This study demonstrated that a12-week exercise training program reduces central blood pressure among patients with resistant hypertension. Our study agrees with previous evidence in patients with prehypertension and hypertension [10,11]. A limitation of this study is that exercise training program consisted of moderate-intensity aerobic exercises. Therefore, other exercise intensities and types of exercise need investigation. This trial demonstrated a benefit of 12-week of moderate-intensity aerobic exercise training on reducing central blood pressure in patients with resistant hypertension. The central blood pressure reduction is clinically promising as theis indicator is associated with target organ damage, cardiovascular risk, and mortality. Ethics committee and informed consent: All patients provided written informed consent. The study was approved by the Ethics Committee of the Centro Hospitalar do Baixo Vouga Clinical study registration number: NCT03090529 Acknowledgements: This work was funded by the European Union through the European Regional Development Fund Operational Competitiveness Factors Program (COMPETE) and by the Portuguese government through the Foundation for Science and Technology (grants P2020-PTDC/DTP-DES/1725/2014 and POCI-01-0145-FEDER-016710). Susana Lopes was awarded with a Portuguese Foundation for Science and Technology PhD grant (grant SFRH/ BD/129454/2017). Institute of Biomedicine (iBiMED; reference No. UID/BIM/04501/2020), Research Centre in Physical Activity, Health and Leisure (CIAFEL; reference No. UID/DTP/00617/ 2020), and Research Center in Sports Sciences, Health and Human Development (CIDESD; reference No. UID/DTP/ 04045/2020) are research units supported by the Portuguese Foundation for Science and Technology. Cátia Leitão is grateful to FCT for the research contract CEECIND/00154/2020 and the projects UIDB/50025/2020, UIDP/50025/2020 and LA/P/0037/2020, financed by national funds through the FCT/MEC. References: 1. Carey RM, Calhoun DA, Bakris GL, Brook RD, Daugherty SL, Dennison-Himmelfarb CR, et al. Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association. Hypertension. 2018;72(5):e53-e90. Epub 2018/10/26. doi: 10.1161/HYP.0000000000000084. PubMed PMID: 30354828; PubMed Central PMCID: PMCPMC6530990. Bakris GL, Townsend RR, Liu M, Cohen SA, D'Agostino R, Flack JM, et al. Impact of renal denervation on 24-hour ambulatory blood pressure: results from SYMPLICITY HTN-3. Journal of the American College of Cardiology. 2014;64(11):1071-8. Epub 2014/05/27. doi: 10.1016/j.jacc.2014.05.012. PubMed PMID: 24858423. Agasthi P, Shipman J, Arsanjani R, Ashukem M, Girardo ME, Yerasi C, et al. Renal Denervation for Resistant Hypertension in the contemporary era: A Systematic Review and Meta-analysis. Sci Rep. 2019;9(1):6200. Epub 2019/04/19. doi: 10.1038/s41598-019-42695-9. PubMed PMID: 30996305; PubMed Central PMCID: PMCPMC6470219. Bhatt DL, Kandzari DE, O'Neill WW, D'Agostino R, Flack JM, Katzen BT, et al. A controlled trial of renal denervation for resistant hypertension. The New England journal of medicine. 2014;370(15):1393-401. Epub 2014/04/01. doi: 10.1056/NEJMoa1402670. PubMed PMID: 24678939. Daugherty SL, Powers JD, Magid DJ, Tavel HM, Masoudi FA, Margolis KL, et al. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation. 2012;125(13):1635-42. doi: 10.1161/CIRCULATIONAHA.111.068064. PubMed PMID: 22379110; PubMed Central PMCID: PMCPMC3343635. Sapoval M, Hale BC, Armstrong S, Da Deppo L, Hertz D, Briggs A. The Burden of Resistant Hypertension in 5 European Countries. Value in Health. 2013;16:A520-A1. doi: 10.1016/j.jval.2013.08.1252. Kollias A, Lagou S, Zeniodi ME, Boubouchairopoulou N, Stergiou GS. Association of Central Versus Brachial Blood Pressure With Target-Organ Damage: Systematic Review and Meta-Analysis. Hypertension. 2016;67(1):183-90. Epub 2015/11/26. doi: 10.1161/HYPERTENSIONAHA.115.06066. PubMed PMID: 26597821. Vlachopoulos C, Aznaouridis K, O'Rourke MF, Safar ME, Baou K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis. European heart journal. 2010;31(15):1865-71. Epub 2010/03/04. doi: 10.1093/eurheartj/ehq024. PubMed PMID: 20197424. Cardoso CRL, Salles GF. Prognostic Value of Changes in Aortic Stiffness for Cardiovascular Outcomes and Mortality in Resistant Hypertension: a Cohort Study. Hypertension. 2022;79(2):447-56. Epub 2022/01/13. doi: 10.1161/HYPERTENSIONAHA.121.18498. PubMed PMID: 35020459. Beck DT, Martin JS, Casey DP, Braith RW. Exercise Training Reduces Peripheral Arterial Stiffness and Myocardial Oxygen Demand in Young Prehypertensive Subjects. American Journal of Hypertension. 2013;26:1093-102. doi: 10.1093/ajh/hpt080. Nualnim N, Parkhurst K, Dhindsa M, Tarumi T, Vavrek J, Tanaka H. Effects of Swimming Training on Blood Pressure and Vascular Function in Adults > 50 Years of Age. AMERICAN JOURNAL OF CARDIOLOGY. 2012;109:1005-10. doi: 10.1016/j.amjcard.2011.11.029. Figures captions/legends: Figure 1. Change from baseline to the end of treatment in central blood pressure and carotid-femoral pulse wave velocity in both study groups. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-20T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.34624/jshd.v4i1.29005 oai:proa.ua.pt:article/29005 |
url |
https://doi.org/10.34624/jshd.v4i1.29005 |
identifier_str_mv |
oai:proa.ua.pt:article/29005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://proa.ua.pt/index.php/jshd/article/view/29005 https://doi.org/10.34624/jshd.v4i1.29005 https://proa.ua.pt/index.php/jshd/article/view/29005/20653 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
University of Aveiro (UA) and Hospital Center of Baixo Vouga (CHBV) |
publisher.none.fl_str_mv |
University of Aveiro (UA) and Hospital Center of Baixo Vouga (CHBV) |
dc.source.none.fl_str_mv |
Journal of Statistics on Health Decision; Vol 4 No 1 (2022): Special Issue - Statistics on Health Decision Making: Real World Data; 73-75 Journal of Statistics on Health Decision; vol. 4 n.º 1 (2022): Special Issue - Statistics on Health Decision Making: Real World Data; 73-75 2184-5794 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799130142972313600 |