SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/57633 |
Resumo: | © 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
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SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10CCR10COVID-19Innate lymphoid cellsLung recoverySARS-CoV2© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Accelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS-CoV-2 infection. COVID-19 patients with moderate/severe respiratory failure featured profound depletion of circulating ILCs at hospital admission, in agreement with overall lymphocyte depletion. However, ILCs recovered in direct correlation with lung function improvement as measured by oxygenation index and in negative association with inflammatory and lung/endothelial damage markers like RAGE. While both ILC1 and ILC2 expanded, ILC2 showed the most striking phenotype changes, with CCR10 upregulation in strong correlation with these parameters. Overall, CCR10+ ILC2 emerge as relevant contributors to SARS-CoV-2 pneumonia recovery.This work was funded by the following grants from Fundação para a Ciência e a Tecnologia (FCT), Portugal, through “APOIO ESPECIAL RESEARCH4COVID-19,” project numbers 125 to SMF and 803 to ACT. AMCG and GBF received fellowships funded by FCT (DOCTORATES4COVID-19, 2020.10202.BD) and JANSSEN- CILAG FARMACÊUTICA, respectively.WileyRepositório da Universidade de LisboaGomes, AndréFarias, Guilherme B.Dias Silva, ManuelLaia, JoelTrombetta, Amelia ChiaraGodinho-Santos, AnaRosmaninho, PedroSantos, Diana F.Conceição, Carolina M.Costa Reis, RenatoAdao-Serrano, MariaMota, CatarinaAlmeida, AfonsoSousa, Ana E.Fernandes, Susana M.2023-05-26T14:15:51Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57633engEur J Immunol. 2021 Dec;51(12):3194-32010014-298010.1002/eji.2021493111521-4141info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:06:20Zoai:repositorio.ul.pt:10451/57633Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:09.434202Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10 |
| title |
SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10 |
| spellingShingle |
SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10 Gomes, André CCR10 COVID-19 Innate lymphoid cells Lung recovery SARS-CoV2 |
| title_short |
SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10 |
| title_full |
SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10 |
| title_fullStr |
SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10 |
| title_full_unstemmed |
SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10 |
| title_sort |
SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10 |
| author |
Gomes, André |
| author_facet |
Gomes, André Farias, Guilherme B. Dias Silva, Manuel Laia, Joel Trombetta, Amelia Chiara Godinho-Santos, Ana Rosmaninho, Pedro Santos, Diana F. Conceição, Carolina M. Costa Reis, Renato Adao-Serrano, Maria Mota, Catarina Almeida, Afonso Sousa, Ana E. Fernandes, Susana M. |
| author_role |
author |
| author2 |
Farias, Guilherme B. Dias Silva, Manuel Laia, Joel Trombetta, Amelia Chiara Godinho-Santos, Ana Rosmaninho, Pedro Santos, Diana F. Conceição, Carolina M. Costa Reis, Renato Adao-Serrano, Maria Mota, Catarina Almeida, Afonso Sousa, Ana E. Fernandes, Susana M. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Gomes, André Farias, Guilherme B. Dias Silva, Manuel Laia, Joel Trombetta, Amelia Chiara Godinho-Santos, Ana Rosmaninho, Pedro Santos, Diana F. Conceição, Carolina M. Costa Reis, Renato Adao-Serrano, Maria Mota, Catarina Almeida, Afonso Sousa, Ana E. Fernandes, Susana M. |
| dc.subject.por.fl_str_mv |
CCR10 COVID-19 Innate lymphoid cells Lung recovery SARS-CoV2 |
| topic |
CCR10 COVID-19 Innate lymphoid cells Lung recovery SARS-CoV2 |
| description |
© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2023-05-26T14:15:51Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/57633 |
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http://hdl.handle.net/10451/57633 |
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eng |
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eng |
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Eur J Immunol. 2021 Dec;51(12):3194-3201 0014-2980 10.1002/eji.202149311 1521-4141 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Wiley |
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Wiley |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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