Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications

Detalhes bibliográficos
Autor(a) principal: Amaro, Luis
Data de Publicação: 2020
Outros Autores: Correia, Daniela M., Martins, Pedro M., Botelho, Gabriela, Carabineiro, Sónia A. C., Ribeiro, Clarisse, Lanceros-Mendez, Senentxu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/103778
Resumo: UID/FIS/04650/2020 UID/BIO/04469/2020 UID/QUI/00686/2020 PTDC/BTM-MAT/28237/2017 PTDC/EMD-EMD/28159/2017 UIDB/50006/2020 SFRH/BPD/121526/2016 MAT2016-76039-C4-3-R PIBA-2018-06
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spelling Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applicationsHydrolytic degradationPiezoelectric materialsPoly(hydroxybutyrate-co-hydroxyvalerate)Tissue engineeringChemistry(all)Polymers and PlasticsUID/FIS/04650/2020 UID/BIO/04469/2020 UID/QUI/00686/2020 PTDC/BTM-MAT/28237/2017 PTDC/EMD-EMD/28159/2017 UIDB/50006/2020 SFRH/BPD/121526/2016 MAT2016-76039-C4-3-R PIBA-2018-06Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a piezoelectric biodegradable and biocompatible polymer suitable for tissue engineering applications. The incorporation of magnetostrictive cobalt ferrites (CFO) into PHBV matrix enables the production of magnetically responsive composites, which proved to be effective in the differentiation of a variety of cells and tissues. In this work, PHBV and PHBV with CFO nanoparticles were produced in the form of films, fibers and porous scaffolds and subjected to an experimental programallowing to evaluate the degradation process under biological conditions for a period up to 8 weeks. Themorphology, physical, chemical and thermal properties were evaluated, together with the weight loss of the samples during the in vitro degradation assays. No major changes in the mentioned properties were found, thus proving its applicability for tissue engineering applications. Degradation was apparent from week 4 and onwards, leading to the conclusion that the degradation ratio of the material is suitable for a large range of tissue engineering applications. Further, it was found that the degradation of the samples maintain the biocompatibility of the materials for the pristine polymer, but can lead to cytotoxic effects when the magnetic CFO nanoparticles are exposed, being therefore needed, for magnetoactive applications, to substitute them by biocompatible ferrites, such as an iron oxide (Fe3O4).LAQV@REQUIMTEDQ - Departamento de QuímicaRUNAmaro, LuisCorreia, Daniela M.Martins, Pedro M.Botelho, GabrielaCarabineiro, Sónia A. C.Ribeiro, ClarisseLanceros-Mendez, Senentxu2020-09-09T02:34:47Z2020-04-012020-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/103778eng1618-7229PURE: 18312200https://doi.org/10.3390/POLYM12040953info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:49:25Zoai:run.unl.pt:10362/103778Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:40:03.541490Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications
title Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications
spellingShingle Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications
Amaro, Luis
Hydrolytic degradation
Piezoelectric materials
Poly(hydroxybutyrate-co-hydroxyvalerate)
Tissue engineering
Chemistry(all)
Polymers and Plastics
title_short Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications
title_full Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications
title_fullStr Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications
title_full_unstemmed Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications
title_sort Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications
author Amaro, Luis
author_facet Amaro, Luis
Correia, Daniela M.
Martins, Pedro M.
Botelho, Gabriela
Carabineiro, Sónia A. C.
Ribeiro, Clarisse
Lanceros-Mendez, Senentxu
author_role author
author2 Correia, Daniela M.
Martins, Pedro M.
Botelho, Gabriela
Carabineiro, Sónia A. C.
Ribeiro, Clarisse
Lanceros-Mendez, Senentxu
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Amaro, Luis
Correia, Daniela M.
Martins, Pedro M.
Botelho, Gabriela
Carabineiro, Sónia A. C.
Ribeiro, Clarisse
Lanceros-Mendez, Senentxu
dc.subject.por.fl_str_mv Hydrolytic degradation
Piezoelectric materials
Poly(hydroxybutyrate-co-hydroxyvalerate)
Tissue engineering
Chemistry(all)
Polymers and Plastics
topic Hydrolytic degradation
Piezoelectric materials
Poly(hydroxybutyrate-co-hydroxyvalerate)
Tissue engineering
Chemistry(all)
Polymers and Plastics
description UID/FIS/04650/2020 UID/BIO/04469/2020 UID/QUI/00686/2020 PTDC/BTM-MAT/28237/2017 PTDC/EMD-EMD/28159/2017 UIDB/50006/2020 SFRH/BPD/121526/2016 MAT2016-76039-C4-3-R PIBA-2018-06
publishDate 2020
dc.date.none.fl_str_mv 2020-09-09T02:34:47Z
2020-04-01
2020-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/103778
url http://hdl.handle.net/10362/103778
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1618-7229
PURE: 18312200
https://doi.org/10.3390/POLYM12040953
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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