Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/103778 |
Resumo: | UID/FIS/04650/2020 UID/BIO/04469/2020 UID/QUI/00686/2020 PTDC/BTM-MAT/28237/2017 PTDC/EMD-EMD/28159/2017 UIDB/50006/2020 SFRH/BPD/121526/2016 MAT2016-76039-C4-3-R PIBA-2018-06 |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applicationsHydrolytic degradationPiezoelectric materialsPoly(hydroxybutyrate-co-hydroxyvalerate)Tissue engineeringChemistry(all)Polymers and PlasticsUID/FIS/04650/2020 UID/BIO/04469/2020 UID/QUI/00686/2020 PTDC/BTM-MAT/28237/2017 PTDC/EMD-EMD/28159/2017 UIDB/50006/2020 SFRH/BPD/121526/2016 MAT2016-76039-C4-3-R PIBA-2018-06Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a piezoelectric biodegradable and biocompatible polymer suitable for tissue engineering applications. The incorporation of magnetostrictive cobalt ferrites (CFO) into PHBV matrix enables the production of magnetically responsive composites, which proved to be effective in the differentiation of a variety of cells and tissues. In this work, PHBV and PHBV with CFO nanoparticles were produced in the form of films, fibers and porous scaffolds and subjected to an experimental programallowing to evaluate the degradation process under biological conditions for a period up to 8 weeks. Themorphology, physical, chemical and thermal properties were evaluated, together with the weight loss of the samples during the in vitro degradation assays. No major changes in the mentioned properties were found, thus proving its applicability for tissue engineering applications. Degradation was apparent from week 4 and onwards, leading to the conclusion that the degradation ratio of the material is suitable for a large range of tissue engineering applications. Further, it was found that the degradation of the samples maintain the biocompatibility of the materials for the pristine polymer, but can lead to cytotoxic effects when the magnetic CFO nanoparticles are exposed, being therefore needed, for magnetoactive applications, to substitute them by biocompatible ferrites, such as an iron oxide (Fe3O4).LAQV@REQUIMTEDQ - Departamento de QuímicaRUNAmaro, LuisCorreia, Daniela M.Martins, Pedro M.Botelho, GabrielaCarabineiro, Sónia A. C.Ribeiro, ClarisseLanceros-Mendez, Senentxu2020-09-09T02:34:47Z2020-04-012020-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/103778eng1618-7229PURE: 18312200https://doi.org/10.3390/POLYM12040953info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:49:25Zoai:run.unl.pt:10362/103778Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:40:03.541490Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications |
title |
Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications |
spellingShingle |
Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications Amaro, Luis Hydrolytic degradation Piezoelectric materials Poly(hydroxybutyrate-co-hydroxyvalerate) Tissue engineering Chemistry(all) Polymers and Plastics |
title_short |
Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications |
title_full |
Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications |
title_fullStr |
Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications |
title_full_unstemmed |
Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications |
title_sort |
Morphology dependence degradation of electro-and magnetoactive poly(3-hydroxybutyrateco-hydroxyvalerate) for tissue engineering applications |
author |
Amaro, Luis |
author_facet |
Amaro, Luis Correia, Daniela M. Martins, Pedro M. Botelho, Gabriela Carabineiro, Sónia A. C. Ribeiro, Clarisse Lanceros-Mendez, Senentxu |
author_role |
author |
author2 |
Correia, Daniela M. Martins, Pedro M. Botelho, Gabriela Carabineiro, Sónia A. C. Ribeiro, Clarisse Lanceros-Mendez, Senentxu |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
LAQV@REQUIMTE DQ - Departamento de Química RUN |
dc.contributor.author.fl_str_mv |
Amaro, Luis Correia, Daniela M. Martins, Pedro M. Botelho, Gabriela Carabineiro, Sónia A. C. Ribeiro, Clarisse Lanceros-Mendez, Senentxu |
dc.subject.por.fl_str_mv |
Hydrolytic degradation Piezoelectric materials Poly(hydroxybutyrate-co-hydroxyvalerate) Tissue engineering Chemistry(all) Polymers and Plastics |
topic |
Hydrolytic degradation Piezoelectric materials Poly(hydroxybutyrate-co-hydroxyvalerate) Tissue engineering Chemistry(all) Polymers and Plastics |
description |
UID/FIS/04650/2020 UID/BIO/04469/2020 UID/QUI/00686/2020 PTDC/BTM-MAT/28237/2017 PTDC/EMD-EMD/28159/2017 UIDB/50006/2020 SFRH/BPD/121526/2016 MAT2016-76039-C4-3-R PIBA-2018-06 |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-09T02:34:47Z 2020-04-01 2020-04-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/103778 |
url |
http://hdl.handle.net/10362/103778 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1618-7229 PURE: 18312200 https://doi.org/10.3390/POLYM12040953 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799138016507199488 |