Hydrodynamics of cholinium chloride-based aqueous biphasic systems (ABS): a key study for their industrial implementation

Detalhes bibliográficos
Autor(a) principal: Jorge, Alexandre M.S.
Data de Publicação: 2023
Outros Autores: Coutinho, João A.P., Pereira, Jorge F.B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/37930
Resumo: Aqueous biphasic systems (ABS) have been widely studied for extraction and purification processes. Although they are considered biocompatible, amenable, and sustainable separation platforms, their application on an industrial scale remains impractical without proper scaling and integration into existing processes. To better understand the hydrodynamics of ABS formation, three cholinium chloride ([Ch]Cl)-based ABS composed of polypropylene glycol with a molecular weight of 400 g.mol−1 (PPG-400), tripotassium phosphate (K3PO4), and dipotassium hydrogen-phosphate (K2HPO4) were studied. The hydrodynamics of phase separation of ABS composed of PPG-400/[Ch]Cl, [Ch]Cl/K3PO4 and [Ch]Cl/K2HPO4 was studied by analysing the relationship between the mixing time (Tm) and the phase settling time (Ts), at 25 °C and 50 °C. The results showed that Ts is independent of Tm, which is very long for the polymer/salt systems (Ts > 6 h), while for salt/salt ABS, a very fast phase settling was observed (Ts < 150 s). The hydrodynamics of each salt/salt system was then correlated with the physicochemical properties of the coexisting phases and the nature of the phase-forming compounds. The increase in the salting-out effect of the inorganic salts, and the consequent larger differences between the compositions of the coexisting phases, improved the hydrodynamics of the [Ch]Cl-based ABS. With the increase of the tie-line lengths, the composition of the phases stabilized, resulting also in more stable physicochemical properties in each phase and constant Ts. The correlations obtained in this work allow the definition of the best operating region within the biphasic (liquid-liquid) region of [Ch]Cl/salt-based ABS as being the largest TLLs within the LLE region. The definition of these criteria and region of operation is crucial for the design and industrial implementation of these types of LLE processes using conventional mixer-settler units.
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spelling Hydrodynamics of cholinium chloride-based aqueous biphasic systems (ABS): a key study for their industrial implementationAqueous two-phase systemsHydrodynamicsCholinium chlorideLiquid-liquid extractionPhase settlingAqueous biphasic systems (ABS) have been widely studied for extraction and purification processes. Although they are considered biocompatible, amenable, and sustainable separation platforms, their application on an industrial scale remains impractical without proper scaling and integration into existing processes. To better understand the hydrodynamics of ABS formation, three cholinium chloride ([Ch]Cl)-based ABS composed of polypropylene glycol with a molecular weight of 400 g.mol−1 (PPG-400), tripotassium phosphate (K3PO4), and dipotassium hydrogen-phosphate (K2HPO4) were studied. The hydrodynamics of phase separation of ABS composed of PPG-400/[Ch]Cl, [Ch]Cl/K3PO4 and [Ch]Cl/K2HPO4 was studied by analysing the relationship between the mixing time (Tm) and the phase settling time (Ts), at 25 °C and 50 °C. The results showed that Ts is independent of Tm, which is very long for the polymer/salt systems (Ts > 6 h), while for salt/salt ABS, a very fast phase settling was observed (Ts < 150 s). The hydrodynamics of each salt/salt system was then correlated with the physicochemical properties of the coexisting phases and the nature of the phase-forming compounds. The increase in the salting-out effect of the inorganic salts, and the consequent larger differences between the compositions of the coexisting phases, improved the hydrodynamics of the [Ch]Cl-based ABS. With the increase of the tie-line lengths, the composition of the phases stabilized, resulting also in more stable physicochemical properties in each phase and constant Ts. The correlations obtained in this work allow the definition of the best operating region within the biphasic (liquid-liquid) region of [Ch]Cl/salt-based ABS as being the largest TLLs within the LLE region. The definition of these criteria and region of operation is crucial for the design and industrial implementation of these types of LLE processes using conventional mixer-settler units.Elsevier2023-06-02T13:55:59Z2023-09-01T00:00:00Z2023-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/37930eng1383-586610.1016/j.seppur.2023.124183Jorge, Alexandre M.S.Coutinho, João A.P.Pereira, Jorge F.B.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:14:04Zoai:ria.ua.pt:10773/37930Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:08:31.237999Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hydrodynamics of cholinium chloride-based aqueous biphasic systems (ABS): a key study for their industrial implementation
title Hydrodynamics of cholinium chloride-based aqueous biphasic systems (ABS): a key study for their industrial implementation
spellingShingle Hydrodynamics of cholinium chloride-based aqueous biphasic systems (ABS): a key study for their industrial implementation
Jorge, Alexandre M.S.
Aqueous two-phase systems
Hydrodynamics
Cholinium chloride
Liquid-liquid extraction
Phase settling
title_short Hydrodynamics of cholinium chloride-based aqueous biphasic systems (ABS): a key study for their industrial implementation
title_full Hydrodynamics of cholinium chloride-based aqueous biphasic systems (ABS): a key study for their industrial implementation
title_fullStr Hydrodynamics of cholinium chloride-based aqueous biphasic systems (ABS): a key study for their industrial implementation
title_full_unstemmed Hydrodynamics of cholinium chloride-based aqueous biphasic systems (ABS): a key study for their industrial implementation
title_sort Hydrodynamics of cholinium chloride-based aqueous biphasic systems (ABS): a key study for their industrial implementation
author Jorge, Alexandre M.S.
author_facet Jorge, Alexandre M.S.
Coutinho, João A.P.
Pereira, Jorge F.B.
author_role author
author2 Coutinho, João A.P.
Pereira, Jorge F.B.
author2_role author
author
dc.contributor.author.fl_str_mv Jorge, Alexandre M.S.
Coutinho, João A.P.
Pereira, Jorge F.B.
dc.subject.por.fl_str_mv Aqueous two-phase systems
Hydrodynamics
Cholinium chloride
Liquid-liquid extraction
Phase settling
topic Aqueous two-phase systems
Hydrodynamics
Cholinium chloride
Liquid-liquid extraction
Phase settling
description Aqueous biphasic systems (ABS) have been widely studied for extraction and purification processes. Although they are considered biocompatible, amenable, and sustainable separation platforms, their application on an industrial scale remains impractical without proper scaling and integration into existing processes. To better understand the hydrodynamics of ABS formation, three cholinium chloride ([Ch]Cl)-based ABS composed of polypropylene glycol with a molecular weight of 400 g.mol−1 (PPG-400), tripotassium phosphate (K3PO4), and dipotassium hydrogen-phosphate (K2HPO4) were studied. The hydrodynamics of phase separation of ABS composed of PPG-400/[Ch]Cl, [Ch]Cl/K3PO4 and [Ch]Cl/K2HPO4 was studied by analysing the relationship between the mixing time (Tm) and the phase settling time (Ts), at 25 °C and 50 °C. The results showed that Ts is independent of Tm, which is very long for the polymer/salt systems (Ts > 6 h), while for salt/salt ABS, a very fast phase settling was observed (Ts < 150 s). The hydrodynamics of each salt/salt system was then correlated with the physicochemical properties of the coexisting phases and the nature of the phase-forming compounds. The increase in the salting-out effect of the inorganic salts, and the consequent larger differences between the compositions of the coexisting phases, improved the hydrodynamics of the [Ch]Cl-based ABS. With the increase of the tie-line lengths, the composition of the phases stabilized, resulting also in more stable physicochemical properties in each phase and constant Ts. The correlations obtained in this work allow the definition of the best operating region within the biphasic (liquid-liquid) region of [Ch]Cl/salt-based ABS as being the largest TLLs within the LLE region. The definition of these criteria and region of operation is crucial for the design and industrial implementation of these types of LLE processes using conventional mixer-settler units.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-02T13:55:59Z
2023-09-01T00:00:00Z
2023-09-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/37930
url http://hdl.handle.net/10773/37930
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1383-5866
10.1016/j.seppur.2023.124183
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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