Recent insights into mitochondrial targeting strategies in liver transplantation

Detalhes bibliográficos
Autor(a) principal: Martins, Rui Miguel
Data de Publicação: 2018
Outros Autores: Teodoro, João Soeiro, Furtado, Emanuel, Rolo, Anabela Pinto, Palmeira, Carlos Marques, Tralhão, José Guilherme
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/107689
https://doi.org/10.7150/ijms.22891
Resumo: Ischemia/reperfusion (I/R) injury in liver transplantation can disrupt the normal activity of mitochondria in the hepatic parenchyma. This potential dysfunction of mitochondria after I/R injury could be responsible for the initial poor graft function or primary nonfunction observed after liver transplantation. Thus, determining the mechanisms that lead to human hepatic mitochondrial dysfunction might contribute to improving the outcome of liver transplantation. Furthermore, early identification of novel prognostic factors involved in I/R injury could serve as a key endpoint to predict the outcome of liver grafts and also to promote the early adoption of novel strategies that protect against I/R injury. Here, we briefly review recent advances in the study of mitochondrial dysfunction and I/R injury, particularly in relation to liver transplantation. Next, we highlight various pharmacological therapeutic strategies that could be applied, and discuss their relationship to relevant mitochondrion-related processes and targets. Lastly, we note that although considerable progress has been made in our understanding of I/R injury and mitochondrial dysfunction, further investigation is required to elucidate the cellular and molecular mechanisms underlying these processes, thereby identifying biomarkers that can help in evaluating donor organs.
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spelling Recent insights into mitochondrial targeting strategies in liver transplantationLiver transplantationMitochondriaIschemia/reperfusion injuryLiver preservation solutionPharmacological conditioningApoptosisHumansLiverLiver TransplantationMitochondriaProtective AgentsReperfusion InjuryIschemia/reperfusion (I/R) injury in liver transplantation can disrupt the normal activity of mitochondria in the hepatic parenchyma. This potential dysfunction of mitochondria after I/R injury could be responsible for the initial poor graft function or primary nonfunction observed after liver transplantation. Thus, determining the mechanisms that lead to human hepatic mitochondrial dysfunction might contribute to improving the outcome of liver transplantation. Furthermore, early identification of novel prognostic factors involved in I/R injury could serve as a key endpoint to predict the outcome of liver grafts and also to promote the early adoption of novel strategies that protect against I/R injury. Here, we briefly review recent advances in the study of mitochondrial dysfunction and I/R injury, particularly in relation to liver transplantation. Next, we highlight various pharmacological therapeutic strategies that could be applied, and discuss their relationship to relevant mitochondrion-related processes and targets. Lastly, we note that although considerable progress has been made in our understanding of I/R injury and mitochondrial dysfunction, further investigation is required to elucidate the cellular and molecular mechanisms underlying these processes, thereby identifying biomarkers that can help in evaluating donor organs.Ivyspring International Publisher2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107689http://hdl.handle.net/10316/107689https://doi.org/10.7150/ijms.22891eng1449-1907Martins, Rui MiguelTeodoro, João SoeiroFurtado, EmanuelRolo, Anabela PintoPalmeira, Carlos MarquesTralhão, José Guilhermeinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-27T09:28:24Zoai:estudogeral.uc.pt:10316/107689Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:24:00.651356Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Recent insights into mitochondrial targeting strategies in liver transplantation
title Recent insights into mitochondrial targeting strategies in liver transplantation
spellingShingle Recent insights into mitochondrial targeting strategies in liver transplantation
Martins, Rui Miguel
Liver transplantation
Mitochondria
Ischemia/reperfusion injury
Liver preservation solution
Pharmacological conditioning
Apoptosis
Humans
Liver
Liver Transplantation
Mitochondria
Protective Agents
Reperfusion Injury
title_short Recent insights into mitochondrial targeting strategies in liver transplantation
title_full Recent insights into mitochondrial targeting strategies in liver transplantation
title_fullStr Recent insights into mitochondrial targeting strategies in liver transplantation
title_full_unstemmed Recent insights into mitochondrial targeting strategies in liver transplantation
title_sort Recent insights into mitochondrial targeting strategies in liver transplantation
author Martins, Rui Miguel
author_facet Martins, Rui Miguel
Teodoro, João Soeiro
Furtado, Emanuel
Rolo, Anabela Pinto
Palmeira, Carlos Marques
Tralhão, José Guilherme
author_role author
author2 Teodoro, João Soeiro
Furtado, Emanuel
Rolo, Anabela Pinto
Palmeira, Carlos Marques
Tralhão, José Guilherme
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Martins, Rui Miguel
Teodoro, João Soeiro
Furtado, Emanuel
Rolo, Anabela Pinto
Palmeira, Carlos Marques
Tralhão, José Guilherme
dc.subject.por.fl_str_mv Liver transplantation
Mitochondria
Ischemia/reperfusion injury
Liver preservation solution
Pharmacological conditioning
Apoptosis
Humans
Liver
Liver Transplantation
Mitochondria
Protective Agents
Reperfusion Injury
topic Liver transplantation
Mitochondria
Ischemia/reperfusion injury
Liver preservation solution
Pharmacological conditioning
Apoptosis
Humans
Liver
Liver Transplantation
Mitochondria
Protective Agents
Reperfusion Injury
description Ischemia/reperfusion (I/R) injury in liver transplantation can disrupt the normal activity of mitochondria in the hepatic parenchyma. This potential dysfunction of mitochondria after I/R injury could be responsible for the initial poor graft function or primary nonfunction observed after liver transplantation. Thus, determining the mechanisms that lead to human hepatic mitochondrial dysfunction might contribute to improving the outcome of liver transplantation. Furthermore, early identification of novel prognostic factors involved in I/R injury could serve as a key endpoint to predict the outcome of liver grafts and also to promote the early adoption of novel strategies that protect against I/R injury. Here, we briefly review recent advances in the study of mitochondrial dysfunction and I/R injury, particularly in relation to liver transplantation. Next, we highlight various pharmacological therapeutic strategies that could be applied, and discuss their relationship to relevant mitochondrion-related processes and targets. Lastly, we note that although considerable progress has been made in our understanding of I/R injury and mitochondrial dysfunction, further investigation is required to elucidate the cellular and molecular mechanisms underlying these processes, thereby identifying biomarkers that can help in evaluating donor organs.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/107689
http://hdl.handle.net/10316/107689
https://doi.org/10.7150/ijms.22891
url http://hdl.handle.net/10316/107689
https://doi.org/10.7150/ijms.22891
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1449-1907
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Ivyspring International Publisher
publisher.none.fl_str_mv Ivyspring International Publisher
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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