Risk Factors for Healthcare Associated Sepsis in Very Low Birth Weight Infants

Detalhes bibliográficos
Autor(a) principal: Pereira, Helena
Data de Publicação: 2016
Outros Autores: Grilo, Ema, Cardoso, Patrícia, Noronha, Natália, Resende, Cristina
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6839
Resumo: Introduction: Healthcare associated infections in very low birth weight infants are associated with significant morbidity and mortality and are also a cause of increased length of stay and hospital costs. The objective of this study was to evaluate the rate of healthcare-associated sepsis and associated risk factors in very low birth weight infants.Material and Methods: Retrospective observational study including very low birth weight infants hospitalized in a Neonatal Intensive Care Unit during ten years (2005-2014). We evaluated the association between several risk factors and healthcare-associated sepsis.Results: 461 very low birth weight infants were admitted. There were 110 episodes of HS in 104 very low birth weight infants and 53 episodes of sepsis associated with central vascular catheter. The density of the sepsis was 7.5/1 000 days of hospitalization and the density of central vascular catheter - associated sepsis was 22.6/1 000 days of use. The infants with HS had lower average birth weight and gestational age (959 ± 228 g vs 1191 ± 249 g and 27.6 ± 2 vs 29.8 ± 2.2 weeks), p < 0.001. After adjusting for birth weight and gestational age we verified an association between healthcare-associated sepsis and antibiotic therapy in D1, the duration of parenteral nutrition and central vascular catheter. After logistic regression only the gestational age and duration of parenteral nutrition remained as independent significant risk factors for healthcare-associated sepsis. Discussion: The independent factors for healthcare-associated sepsis are gestational age and duration of parenteral nutrition.Conclusion: For each extra week on gestational age the risk declined in 20% and for each day of NP the risk increased 22%.
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spelling Risk Factors for Healthcare Associated Sepsis in Very Low Birth Weight InfantsFatores de Risco para Sépsis Associada aos Cuidados de Saúde em Recém-nascidos de Muito Baixo PesoCross InfectionInfantLow Birth WeightRisk FactorsSepsis.Factores de RiscoInfecção HospitalarRecém-Nascido de Muito Baixo PesoSépsis.Introduction: Healthcare associated infections in very low birth weight infants are associated with significant morbidity and mortality and are also a cause of increased length of stay and hospital costs. The objective of this study was to evaluate the rate of healthcare-associated sepsis and associated risk factors in very low birth weight infants.Material and Methods: Retrospective observational study including very low birth weight infants hospitalized in a Neonatal Intensive Care Unit during ten years (2005-2014). We evaluated the association between several risk factors and healthcare-associated sepsis.Results: 461 very low birth weight infants were admitted. There were 110 episodes of HS in 104 very low birth weight infants and 53 episodes of sepsis associated with central vascular catheter. The density of the sepsis was 7.5/1 000 days of hospitalization and the density of central vascular catheter - associated sepsis was 22.6/1 000 days of use. The infants with HS had lower average birth weight and gestational age (959 ± 228 g vs 1191 ± 249 g and 27.6 ± 2 vs 29.8 ± 2.2 weeks), p < 0.001. After adjusting for birth weight and gestational age we verified an association between healthcare-associated sepsis and antibiotic therapy in D1, the duration of parenteral nutrition and central vascular catheter. After logistic regression only the gestational age and duration of parenteral nutrition remained as independent significant risk factors for healthcare-associated sepsis. Discussion: The independent factors for healthcare-associated sepsis are gestational age and duration of parenteral nutrition.Conclusion: For each extra week on gestational age the risk declined in 20% and for each day of NP the risk increased 22%.Introdução: As infeções associadas aos cuidados de saúde constituem uma importante causa de morbi-mortalidade neonatal, levando a um aumento do tempo de internamento e consequentemente dos seus custos. O objetivo deste estudo foi avaliar a taxa de incidência de infeções associadas aos cuidados de saúde e os seus principais fatores de risco em recém-nascidos de muito baixo peso.Material e Métodos: Estudo retrospetivo dos recém-nascidos de muito baixo peso internados numa maternidade com apoio perinatal diferenciado, durante um período de 10 anos (2005-2014). Foi analisada a existência de associação entre vários fatores de risco e a ocorrência de infeções associadas aos cuidados de saúde. Resultados: Foram internados 461 recém-nascidos de muito baixo peso. Houve 110 episódios de infeções associadas aos cuidados de saúde em 104 recém-nascidos e 53 episódios de sépsis associada a cateterismo venoso central. A densidade de sépsis foi 7,5/1 000 dias de internamento e a densidade de sépsis associada ao cateterismo venoso central 22,6/1 000 dias de utilização. Os recém-nascidos com infeções associadas aos cuidados de saúde apresentaram uma média de peso ao nascimento e idade gestacional inferior (959 ± 228 g vs 1191 ± 249 g) e (27,6 ± 2 vs 29,8 ± 2,2 semanas), p < 0,001. Após ajuste à idade gestacional e peso ao nascimento verificámos associação entre infeções associadas aos cuidados de saúde e antibioterapia em D1, duração de cateterismo venoso central e da nutrição parentérica. Após regressão logística, mantiveram-se como fatores de risco independentes com significância estatística, a idade gestacional e a duração da nutrição parentérica.Discussão: Os fatores de risco independentes para infeções associadas aos cuidados de saúde foram a idade gestacional e a duração da nutrição parentérica.Conclusão: Por cada semana a mais na idade gestacional o risco de infeções associadas aos cuidados de saúde diminuiu em 20% e por cada dia de nutrição parentérica o risco aumentou em 22%.Ordem dos Médicos2016-04-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/mswordapplication/pdfimage/jpegimage/jpeghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6839oai:ojs.www.actamedicaportuguesa.com:article/6839Acta Médica Portuguesa; Vol. 29 No. 4 (2016): April; 261-267Acta Médica Portuguesa; Vol. 29 N.º 4 (2016): Abril; 261-2671646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6839https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6839/4654https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6839/4903https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6839/8031https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6839/8033https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6839/8094https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6839/8095Direitos de Autor (c) 2016 Acta Médica Portuguesa - Ordem dos Médicosinfo:eu-repo/semantics/openAccessPereira, HelenaGrilo, EmaCardoso, PatríciaNoronha, NatáliaResende, Cristina2022-12-20T11:05:00Zoai:ojs.www.actamedicaportuguesa.com:article/6839Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:22.480836Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Risk Factors for Healthcare Associated Sepsis in Very Low Birth Weight Infants
Fatores de Risco para Sépsis Associada aos Cuidados de Saúde em Recém-nascidos de Muito Baixo Peso
title Risk Factors for Healthcare Associated Sepsis in Very Low Birth Weight Infants
spellingShingle Risk Factors for Healthcare Associated Sepsis in Very Low Birth Weight Infants
Pereira, Helena
Cross Infection
Infant
Low Birth Weight
Risk Factors
Sepsis.
Factores de Risco
Infecção Hospitalar
Recém-Nascido de Muito Baixo Peso
Sépsis.
title_short Risk Factors for Healthcare Associated Sepsis in Very Low Birth Weight Infants
title_full Risk Factors for Healthcare Associated Sepsis in Very Low Birth Weight Infants
title_fullStr Risk Factors for Healthcare Associated Sepsis in Very Low Birth Weight Infants
title_full_unstemmed Risk Factors for Healthcare Associated Sepsis in Very Low Birth Weight Infants
title_sort Risk Factors for Healthcare Associated Sepsis in Very Low Birth Weight Infants
author Pereira, Helena
author_facet Pereira, Helena
Grilo, Ema
Cardoso, Patrícia
Noronha, Natália
Resende, Cristina
author_role author
author2 Grilo, Ema
Cardoso, Patrícia
Noronha, Natália
Resende, Cristina
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Helena
Grilo, Ema
Cardoso, Patrícia
Noronha, Natália
Resende, Cristina
dc.subject.por.fl_str_mv Cross Infection
Infant
Low Birth Weight
Risk Factors
Sepsis.
Factores de Risco
Infecção Hospitalar
Recém-Nascido de Muito Baixo Peso
Sépsis.
topic Cross Infection
Infant
Low Birth Weight
Risk Factors
Sepsis.
Factores de Risco
Infecção Hospitalar
Recém-Nascido de Muito Baixo Peso
Sépsis.
description Introduction: Healthcare associated infections in very low birth weight infants are associated with significant morbidity and mortality and are also a cause of increased length of stay and hospital costs. The objective of this study was to evaluate the rate of healthcare-associated sepsis and associated risk factors in very low birth weight infants.Material and Methods: Retrospective observational study including very low birth weight infants hospitalized in a Neonatal Intensive Care Unit during ten years (2005-2014). We evaluated the association between several risk factors and healthcare-associated sepsis.Results: 461 very low birth weight infants were admitted. There were 110 episodes of HS in 104 very low birth weight infants and 53 episodes of sepsis associated with central vascular catheter. The density of the sepsis was 7.5/1 000 days of hospitalization and the density of central vascular catheter - associated sepsis was 22.6/1 000 days of use. The infants with HS had lower average birth weight and gestational age (959 ± 228 g vs 1191 ± 249 g and 27.6 ± 2 vs 29.8 ± 2.2 weeks), p < 0.001. After adjusting for birth weight and gestational age we verified an association between healthcare-associated sepsis and antibiotic therapy in D1, the duration of parenteral nutrition and central vascular catheter. After logistic regression only the gestational age and duration of parenteral nutrition remained as independent significant risk factors for healthcare-associated sepsis. Discussion: The independent factors for healthcare-associated sepsis are gestational age and duration of parenteral nutrition.Conclusion: For each extra week on gestational age the risk declined in 20% and for each day of NP the risk increased 22%.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-29
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6839/4903
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6839/8031
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6839/8095
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2016 Acta Médica Portuguesa - Ordem dos Médicos
info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 29 No. 4 (2016): April; 261-267
Acta Médica Portuguesa; Vol. 29 N.º 4 (2016): Abril; 261-267
1646-0758
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