Photosensitivity as the Presenting Feature of Human Immunodeficiency Virus Infection
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.78.3.1208 |
Resumo: | Photosensitivity is characterized by an abnormal response to non-ionizing radiation, disclosing a variety of morphological patterns, which reflect their different etiologies. We describe the case of a man presenting with a photosensitive dermatosis with no apparent exogenous cause and refractory to multiple treatments. Phototests revealed a reduction in minimal erythema dose to UVB. Laboratory tests in order to start azathioprine, showed a positive test for HIV and a diagnosis of AIDS (high viral load and low TCD4+ cells). A few months after starting antiretroviral therapy photosensitivity resolved completely. Photosensitivity affects up to 5% of HIV-positive patients, mostly due to drug photosensitivity, but it has also been reported as the presenting sign. The authors emphasize the clinical association between HIV infection and photosensitivity which has been increasingly recognized, although it is still poorly characterized from a clinical and photobiological point of view. |
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Photosensitivity as the Presenting Feature of Human Immunodeficiency Virus InfectionFotossensibilidade como Manifestação Inicial de Infeção por Vírus da Imunodeficiência HumanaHIV Infections/complicationsPhotosensitivity DisordersFotossensibilidadeInfecções por VIH7complicaçõesPhotosensitivity is characterized by an abnormal response to non-ionizing radiation, disclosing a variety of morphological patterns, which reflect their different etiologies. We describe the case of a man presenting with a photosensitive dermatosis with no apparent exogenous cause and refractory to multiple treatments. Phototests revealed a reduction in minimal erythema dose to UVB. Laboratory tests in order to start azathioprine, showed a positive test for HIV and a diagnosis of AIDS (high viral load and low TCD4+ cells). A few months after starting antiretroviral therapy photosensitivity resolved completely. Photosensitivity affects up to 5% of HIV-positive patients, mostly due to drug photosensitivity, but it has also been reported as the presenting sign. The authors emphasize the clinical association between HIV infection and photosensitivity which has been increasingly recognized, although it is still poorly characterized from a clinical and photobiological point of view.As reações de fotossensibilidade caracterizam-se por uma resposta alterada à radiação não-ionizante, apresentando diversos padrões morfológicos, que refletem as suas diferentes etiologias. Relatamos o caso de um doente observado por dermatose fotossensível refratária a múltiplos tratamentos. Excluídas possíveis causas exógenas e após demonstração de uma dose de eritema mínimo diminuída para UVB, o estudo analítico com vista a iniciar azatioprina revelou serologia positiva para VIH, revelando elevada carga viral e contagens TCD4+ reduzidas. Neste seguimento, iniciou de imediato terapêutica anti-retroviral, com resolução rápida e completa do quadro. Estima-se que 5% dos doentes VIH-positivos apresentem fotossensibilidade em algum momento da sua evolução. Mais frequentemente associada a fármacos utilizados no tratamento, a sensibilidade à luz solar tem também sido ocasionalmente descrita como manifestação inicial da infeção, como no presente caso. Os autores pretendem alertar para a associação entre fotossensibilidade e infeção por VIH que, embora tenha vindo a ser crescentemente reconhecida, está ainda pouco caracterizada.Sociedade Portuguesa de Dermatologia e Venereologia2020-09-27T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.78.3.1208oai:ojs.revista.spdv.com.pt:article/1208Journal of the Portuguese Society of Dermatology and Venereology; Vol 78 No 3 (2020): July - September; 261-264Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 78 n. 3 (2020): Julho - Setembro; 261-2642182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://revista.spdv.com.pt/index.php/spdv/article/view/1208https://doi.org/10.29021/spdv.78.3.1208https://revista.spdv.com.pt/index.php/spdv/article/view/1208/854Copyright (c) 2020 Journal of the Portuguese Society of Dermatology and Venereologyhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessRelvas, MariaMorgado, FranciscaOliveira, HugoGonçalo, Margarida2022-10-06T12:35:15Zoai:ojs.revista.spdv.com.pt:article/1208Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:16.363720Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Photosensitivity as the Presenting Feature of Human Immunodeficiency Virus Infection Fotossensibilidade como Manifestação Inicial de Infeção por Vírus da Imunodeficiência Humana |
title |
Photosensitivity as the Presenting Feature of Human Immunodeficiency Virus Infection |
spellingShingle |
Photosensitivity as the Presenting Feature of Human Immunodeficiency Virus Infection Relvas, Maria HIV Infections/complications Photosensitivity Disorders Fotossensibilidade Infecções por VIH7complicações |
title_short |
Photosensitivity as the Presenting Feature of Human Immunodeficiency Virus Infection |
title_full |
Photosensitivity as the Presenting Feature of Human Immunodeficiency Virus Infection |
title_fullStr |
Photosensitivity as the Presenting Feature of Human Immunodeficiency Virus Infection |
title_full_unstemmed |
Photosensitivity as the Presenting Feature of Human Immunodeficiency Virus Infection |
title_sort |
Photosensitivity as the Presenting Feature of Human Immunodeficiency Virus Infection |
author |
Relvas, Maria |
author_facet |
Relvas, Maria Morgado, Francisca Oliveira, Hugo Gonçalo, Margarida |
author_role |
author |
author2 |
Morgado, Francisca Oliveira, Hugo Gonçalo, Margarida |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Relvas, Maria Morgado, Francisca Oliveira, Hugo Gonçalo, Margarida |
dc.subject.por.fl_str_mv |
HIV Infections/complications Photosensitivity Disorders Fotossensibilidade Infecções por VIH7complicações |
topic |
HIV Infections/complications Photosensitivity Disorders Fotossensibilidade Infecções por VIH7complicações |
description |
Photosensitivity is characterized by an abnormal response to non-ionizing radiation, disclosing a variety of morphological patterns, which reflect their different etiologies. We describe the case of a man presenting with a photosensitive dermatosis with no apparent exogenous cause and refractory to multiple treatments. Phototests revealed a reduction in minimal erythema dose to UVB. Laboratory tests in order to start azathioprine, showed a positive test for HIV and a diagnosis of AIDS (high viral load and low TCD4+ cells). A few months after starting antiretroviral therapy photosensitivity resolved completely. Photosensitivity affects up to 5% of HIV-positive patients, mostly due to drug photosensitivity, but it has also been reported as the presenting sign. The authors emphasize the clinical association between HIV infection and photosensitivity which has been increasingly recognized, although it is still poorly characterized from a clinical and photobiological point of view. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-27T00:00:00Z |
dc.type.driver.fl_str_mv |
journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.78.3.1208 oai:ojs.revista.spdv.com.pt:article/1208 |
url |
https://doi.org/10.29021/spdv.78.3.1208 |
identifier_str_mv |
oai:ojs.revista.spdv.com.pt:article/1208 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.spdv.com.pt/index.php/spdv/article/view/1208 https://doi.org/10.29021/spdv.78.3.1208 https://revista.spdv.com.pt/index.php/spdv/article/view/1208/854 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Journal of the Portuguese Society of Dermatology and Venereology https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Journal of the Portuguese Society of Dermatology and Venereology https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 78 No 3 (2020): July - September; 261-264 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 78 n. 3 (2020): Julho - Setembro; 261-264 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130568452997120 |