Parâmetros que demonstram ter influência na resposta à terapia neoadjuvante em pacientes com cancro da mama: Estado da arte e perspetivas futuras

• Autor(a) principal: Maria Isabel da Silva Carvalho
• Data de Publicação: 2021
• Tipo de documento: Dissertação
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://hdl.handle.net/10216/134484
• topic: Ciências médicas e da saúde; Medical and Health sciences

Goals: The breast cancer extensive heterogeneity, together with the variability of therapeutic responses, raises the need to distinguish the tumor specific factors of neoadjuvant therapy (NAT) resistance. The present review comprises an overview of the recent literature related with this topic. Methods: The bibliographic search was conducted in the PubMed database focusing on relevant manuscripts with publication date in 2015 or later. Outcomes: Younger age, smaller tumor size, absence of axillary lymph node involvement, histological grade III, high Ki-67, ER negative, HER2 positive and triple negative breast cancer are factors that predict a good response to NAT. Tumor infiltrating immune cells, PIK3CA mutation, BRCA status and agnostic markers still under investigation and seems to be promising candidates. Conclusions: More than individual biomarkers, a panel of combined multilevel parameters may be able to predict patient's therapeutic response. Nevertheless, the clinical utility of these new promising factors still requires additional reliable evidence in multicenter clinical trials.