Bioadhesive hyaluronic acid-based hydrogels for spinal cord injury

• Autor(a) principal: Duarte, Diogo
• Data de Publicação: 2024
• Outros Autores: Correia, Cátia, Reis, R. L., Pashkuleva, I., Peixoto, Daniela, Alves, N. M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://hdl.handle.net/1822/89170
• topic: Adhesive hydrogels; Hyaluronic acid; Ibuprofen; Neuronal regeneration; Spinal cord injury

Spinal cord injuries (SCI) have devastating physical, psychological, and psycho-social consequences for patients. One challenge of nerve tissue repair is the lack of a natural extracellular matrix (ECM) that guides the regenerating axons. Hyaluronic acid (HA) is a major ECM component and plays a fundamental role in facilitating lesion healing. Herein, we developed HA-based adhesive hydrogels by modification of HA with dopamine, a mussel-inspired compound with excellent adhesive properties in anaqueous environment. The hydrogels were loaded with the anti-inflammatory drug ibuprofen and the response of neuronal cells (SH-SY5Y) was evaluated in terms of viability, morphology, and adhesion.The obtained results suggested that the developed materials can bridge lesion gaps, guide axonal growth, and simultaneously act as a vehicle for the delivery of bioactive compounds.