Optic Disc Structural, Vascular and Functional Assessment in Patients with Primary Raynaud’s Phenomenon
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.48560/rspo.26683 |
Resumo: | INTRODUCTION: Our aim was to assess optic disc structural, vascular and functional parameters in patients with primary Raynaud’s phenomenon (PRP). METHODS: This study enrolled patients with PRP and healthy age-matched controls. Subjects underwent evaluation of intraocular pressure (IOP), anterior chamber angle, optic disc structural and vascular parameters (measured by optical coherence tomography) and visual field. RESULTS: Twenty-four eyes were included in the control group, with a mean age of 44.20 ± 4.67 years, and 20 eyes in the PRP group, with a mean age of 43.00 ± 6.08 years (p=0.20). Inferior and nasal retinal nerve fiber layer (RNFL) thickness was lower in PRP group (104.05 ± 17.64 vs 118.67 ± 12.60μm, p=0.01; 70.05 ± 12.21 vs 79.50 ± 12.70 μm, p=0.04, respectively). Vascular density was lower in PRP group, mostly in the inner ring (15.90 ± 2.10 vs 14.20 ± 0.43 mm-1, p=0.02). No difference was found in functional parameters (p>0.05). No correlation was found between optic disc vascular density and RNFL thickness on multivariate regression analysis (p>0.05). CONCLUSION: Our findings suggest that PRP may possibly negatively affect the optic nerve, with a reduced vascular density and RNFL thickness. |
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Optic Disc Structural, Vascular and Functional Assessment in Patients with Primary Raynaud’s PhenomenonAvaliação Estrutural, Vascular e Funcional do Disco Ótico em Doentes com Fenómeno de Raynaud PrimárioArtigos OriginaisINTRODUCTION: Our aim was to assess optic disc structural, vascular and functional parameters in patients with primary Raynaud’s phenomenon (PRP). METHODS: This study enrolled patients with PRP and healthy age-matched controls. Subjects underwent evaluation of intraocular pressure (IOP), anterior chamber angle, optic disc structural and vascular parameters (measured by optical coherence tomography) and visual field. RESULTS: Twenty-four eyes were included in the control group, with a mean age of 44.20 ± 4.67 years, and 20 eyes in the PRP group, with a mean age of 43.00 ± 6.08 years (p=0.20). Inferior and nasal retinal nerve fiber layer (RNFL) thickness was lower in PRP group (104.05 ± 17.64 vs 118.67 ± 12.60μm, p=0.01; 70.05 ± 12.21 vs 79.50 ± 12.70 μm, p=0.04, respectively). Vascular density was lower in PRP group, mostly in the inner ring (15.90 ± 2.10 vs 14.20 ± 0.43 mm-1, p=0.02). No difference was found in functional parameters (p>0.05). No correlation was found between optic disc vascular density and RNFL thickness on multivariate regression analysis (p>0.05). CONCLUSION: Our findings suggest that PRP may possibly negatively affect the optic nerve, with a reduced vascular density and RNFL thickness.INTRODUÇÃO: O nosso objetivo foi avaliar os parâmetros estruturais, vasculares e funcio- nais do disco ótico em doentes com fenómeno de Raynaud primário (FRP). MÉTODOS: Este estudo incluiu pacientes com FRP e controlos saudáveis de idade equi- valente. Avaliou-se a pressão intraocular (PIO), ângulo iridocorneano, parâmetros estruturais e vasculares do disco ótico (determinados por tomografia de coerência ótica) e os campos visuais. RESULTADOS: Foram incluídos 24 olhos no grupo de Controlo, com uma idade média de 44,20 ± 4,67 anos, e 20 olhos no grupo de FRP, com uma média de idade de 43,00 ± 6,08 anos (p=0,20). A espessura nasal e inferior da camada de fibras nervosas (CFN) foi inferior no grupo de FRP (104,05 ± 17,64 vs 118,67 ± 12,60 μm, p=0,01; 7,.05 ± 12,21 vs 79,50 ± 12,70 μm, p=0,04, respetivamente). A densidade vascular foi igualmente inferior no grupo de FRP group, particularmente no anel interno (15,90 ± 2,10 vs 14,20 ± 0,43 mm-1, p=0,02). Não foram encontradas diferenças nos parâmetros funcionais (p0,05). Não se verificou uma correlação entre a densidade vascular do disco óticos e a espessura da CFN na análise de regressão multivariada (p0,05). CONCLUSÃO: Os nossos achados sugerem que a FRP pode afetar negativamente o nervo ótico, com uma menor densidade vascular e espessura da CFN face a uma população normal.Ajnet2022-09-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.48560/rspo.26683eng1646-69501646-6950Carreira, Ana RitaMarques, NadineCarreira, PedroMoraes, FilipeLoureiro, TomásRodrigues-Barros, SandraTelles Freitas, PaulaCardoso, JoãoCampos, Nunoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-13T20:30:16Zoai:ojs.revistas.rcaap.pt:article/26683Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:23.295245Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Optic Disc Structural, Vascular and Functional Assessment in Patients with Primary Raynaud’s Phenomenon Avaliação Estrutural, Vascular e Funcional do Disco Ótico em Doentes com Fenómeno de Raynaud Primário |
title |
Optic Disc Structural, Vascular and Functional Assessment in Patients with Primary Raynaud’s Phenomenon |
spellingShingle |
Optic Disc Structural, Vascular and Functional Assessment in Patients with Primary Raynaud’s Phenomenon Carreira, Ana Rita Artigos Originais |
title_short |
Optic Disc Structural, Vascular and Functional Assessment in Patients with Primary Raynaud’s Phenomenon |
title_full |
Optic Disc Structural, Vascular and Functional Assessment in Patients with Primary Raynaud’s Phenomenon |
title_fullStr |
Optic Disc Structural, Vascular and Functional Assessment in Patients with Primary Raynaud’s Phenomenon |
title_full_unstemmed |
Optic Disc Structural, Vascular and Functional Assessment in Patients with Primary Raynaud’s Phenomenon |
title_sort |
Optic Disc Structural, Vascular and Functional Assessment in Patients with Primary Raynaud’s Phenomenon |
author |
Carreira, Ana Rita |
author_facet |
Carreira, Ana Rita Marques, Nadine Carreira, Pedro Moraes, Filipe Loureiro, Tomás Rodrigues-Barros, Sandra Telles Freitas, Paula Cardoso, João Campos, Nuno |
author_role |
author |
author2 |
Marques, Nadine Carreira, Pedro Moraes, Filipe Loureiro, Tomás Rodrigues-Barros, Sandra Telles Freitas, Paula Cardoso, João Campos, Nuno |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Carreira, Ana Rita Marques, Nadine Carreira, Pedro Moraes, Filipe Loureiro, Tomás Rodrigues-Barros, Sandra Telles Freitas, Paula Cardoso, João Campos, Nuno |
dc.subject.por.fl_str_mv |
Artigos Originais |
topic |
Artigos Originais |
description |
INTRODUCTION: Our aim was to assess optic disc structural, vascular and functional parameters in patients with primary Raynaud’s phenomenon (PRP). METHODS: This study enrolled patients with PRP and healthy age-matched controls. Subjects underwent evaluation of intraocular pressure (IOP), anterior chamber angle, optic disc structural and vascular parameters (measured by optical coherence tomography) and visual field. RESULTS: Twenty-four eyes were included in the control group, with a mean age of 44.20 ± 4.67 years, and 20 eyes in the PRP group, with a mean age of 43.00 ± 6.08 years (p=0.20). Inferior and nasal retinal nerve fiber layer (RNFL) thickness was lower in PRP group (104.05 ± 17.64 vs 118.67 ± 12.60μm, p=0.01; 70.05 ± 12.21 vs 79.50 ± 12.70 μm, p=0.04, respectively). Vascular density was lower in PRP group, mostly in the inner ring (15.90 ± 2.10 vs 14.20 ± 0.43 mm-1, p=0.02). No difference was found in functional parameters (p>0.05). No correlation was found between optic disc vascular density and RNFL thickness on multivariate regression analysis (p>0.05). CONCLUSION: Our findings suggest that PRP may possibly negatively affect the optic nerve, with a reduced vascular density and RNFL thickness. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-30T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.48560/rspo.26683 |
url |
https://doi.org/10.48560/rspo.26683 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1646-6950 1646-6950 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Ajnet |
publisher.none.fl_str_mv |
Ajnet |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130569625305088 |