Accuracy of NIPT for detection  of T21,T18  and T13 in twin pregnancies: Systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Maria Teresa de Azeredo Pais Caroto
Data de Publicação: 2021
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/139758
Resumo: The aim of this systematic review was to evaluate the performance of non-invasive prenatal test (NIPT) in recognising trisomy 21 (T21), trisomy 18 (T18) and trisomy 13 (T13) in twin pregnancies. Web of Science, Medline and ClinicalTrials databases were searched electronically from January of 2020 up to 24th of December 2020. Studies were selected based on eligibility criteria and availability regarding outcome data. Out of 280 identified titles arising from the search strategy, 11 studies were included. Of these, four corresponded to twin pregnancies and seven concerned singleton pregnancies. In the primary target group, detection rate as well as specificity was outstanding as for T21. The equivalent cannot be assumed for T18 and T13 due to the reduced number of studies reporting accuracy. The performance of NIPT for all aneuploidies in singletons was up to the mark and as predicted from prior studies.
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spelling Accuracy of NIPT for detection  of T21,T18  and T13 in twin pregnancies: Systematic review and meta-analysisCiências médicas e da saúdeMedical and Health sciencesThe aim of this systematic review was to evaluate the performance of non-invasive prenatal test (NIPT) in recognising trisomy 21 (T21), trisomy 18 (T18) and trisomy 13 (T13) in twin pregnancies. Web of Science, Medline and ClinicalTrials databases were searched electronically from January of 2020 up to 24th of December 2020. Studies were selected based on eligibility criteria and availability regarding outcome data. Out of 280 identified titles arising from the search strategy, 11 studies were included. Of these, four corresponded to twin pregnancies and seven concerned singleton pregnancies. In the primary target group, detection rate as well as specificity was outstanding as for T21. The equivalent cannot be assumed for T18 and T13 due to the reduced number of studies reporting accuracy. The performance of NIPT for all aneuploidies in singletons was up to the mark and as predicted from prior studies.2021-07-072021-07-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://hdl.handle.net/10216/139758TID:203178572engMaria Teresa de Azeredo Pais Carotoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:10:44Zoai:repositorio-aberto.up.pt:10216/139758Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:17:27.165517Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Accuracy of NIPT for detection  of T21,T18  and T13 in twin pregnancies: Systematic review and meta-analysis
title Accuracy of NIPT for detection  of T21,T18  and T13 in twin pregnancies: Systematic review and meta-analysis
spellingShingle Accuracy of NIPT for detection  of T21,T18  and T13 in twin pregnancies: Systematic review and meta-analysis
Maria Teresa de Azeredo Pais Caroto
Ciências médicas e da saúde
Medical and Health sciences
title_short Accuracy of NIPT for detection  of T21,T18  and T13 in twin pregnancies: Systematic review and meta-analysis
title_full Accuracy of NIPT for detection  of T21,T18  and T13 in twin pregnancies: Systematic review and meta-analysis
title_fullStr Accuracy of NIPT for detection  of T21,T18  and T13 in twin pregnancies: Systematic review and meta-analysis
title_full_unstemmed Accuracy of NIPT for detection  of T21,T18  and T13 in twin pregnancies: Systematic review and meta-analysis
title_sort Accuracy of NIPT for detection  of T21,T18  and T13 in twin pregnancies: Systematic review and meta-analysis
author Maria Teresa de Azeredo Pais Caroto
author_facet Maria Teresa de Azeredo Pais Caroto
author_role author
dc.contributor.author.fl_str_mv Maria Teresa de Azeredo Pais Caroto
dc.subject.por.fl_str_mv Ciências médicas e da saúde
Medical and Health sciences
topic Ciências médicas e da saúde
Medical and Health sciences
description The aim of this systematic review was to evaluate the performance of non-invasive prenatal test (NIPT) in recognising trisomy 21 (T21), trisomy 18 (T18) and trisomy 13 (T13) in twin pregnancies. Web of Science, Medline and ClinicalTrials databases were searched electronically from January of 2020 up to 24th of December 2020. Studies were selected based on eligibility criteria and availability regarding outcome data. Out of 280 identified titles arising from the search strategy, 11 studies were included. Of these, four corresponded to twin pregnancies and seven concerned singleton pregnancies. In the primary target group, detection rate as well as specificity was outstanding as for T21. The equivalent cannot be assumed for T18 and T13 due to the reduced number of studies reporting accuracy. The performance of NIPT for all aneuploidies in singletons was up to the mark and as predicted from prior studies.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-07
2021-07-07T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/139758
TID:203178572
url https://hdl.handle.net/10216/139758
identifier_str_mv TID:203178572
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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