Cariprazine use in early psychosis: three case reports
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/50742 |
Resumo: | Copyright © 2021 Coentre, Saraiva, Sereijo and Levy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Cariprazine use in early psychosis: three case reportsCariprazineCase reportEarly interventionEarly psychosisFirst-episode psychosisSchizophreniaCopyright © 2021 Coentre, Saraiva, Sereijo and Levy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Objective: Cariprazine is a new atypical antipsychotic approved for the acute and maintenance treatment of schizophrenia (1, 2) and for the treatment of manic or mixed episodes associated with bipolar I disorder (1). Recently, cariprazine also got extended FDA-approval for the treatment of depressive episodes in adults with bipolar I disorder (3). The use of low doses of atypical antipsychotics is an essential component of early intervention in psychosis. For its particular performance and tolerability, cariprazine is becoming an important option for the treatment of first-episode psychosis. Method: Three patients experiencing first-episode psychosis (FEP) were successfully treated with cariprazine. Two patients were in their first months of the disease, and the third patient was in his third year after the FEP. Results: The three patients had a diagnosis of non-affective FEP, which includes schizophrenia, delusional disorder, and schizoaffective disorder. One of them was in their third year after the FEP with a predominance of negative symptoms at this stage of the disorder. All the patients were treated with cariprazine with a target dose of 3-4.5 mg/day. The three patients showed improvements in their psychosis, including a decrease in negative symptoms. No significant side effects were reported. Conclusion: Our three case reports indicate that cariprazine is an atypical antipsychotic beneficial in the treatment of early psychosis. Treatment with low doses of cariprazine could be effective and tolerable in this phase of the disorder. Future studies with longer follow-up of FEP patients are recommended to confirm these positive results of cariprazine in the early phases of psychosis.FrontiersRepositório da Universidade de LisboaCoentre, RicardoSaraiva, RodrigoSereijo, CarolinaLevy, Pedro2022-01-07T15:42:06Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50742engFront Psychiatry. 2021 Dec 16;12:78828110.3389/fpsyt.2021.7882811664-0640info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:55:04Zoai:repositorio.ul.pt:10451/50742Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:08.356701Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cariprazine use in early psychosis: three case reports |
title |
Cariprazine use in early psychosis: three case reports |
spellingShingle |
Cariprazine use in early psychosis: three case reports Coentre, Ricardo Cariprazine Case report Early intervention Early psychosis First-episode psychosis Schizophrenia |
title_short |
Cariprazine use in early psychosis: three case reports |
title_full |
Cariprazine use in early psychosis: three case reports |
title_fullStr |
Cariprazine use in early psychosis: three case reports |
title_full_unstemmed |
Cariprazine use in early psychosis: three case reports |
title_sort |
Cariprazine use in early psychosis: three case reports |
author |
Coentre, Ricardo |
author_facet |
Coentre, Ricardo Saraiva, Rodrigo Sereijo, Carolina Levy, Pedro |
author_role |
author |
author2 |
Saraiva, Rodrigo Sereijo, Carolina Levy, Pedro |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Coentre, Ricardo Saraiva, Rodrigo Sereijo, Carolina Levy, Pedro |
dc.subject.por.fl_str_mv |
Cariprazine Case report Early intervention Early psychosis First-episode psychosis Schizophrenia |
topic |
Cariprazine Case report Early intervention Early psychosis First-episode psychosis Schizophrenia |
description |
Copyright © 2021 Coentre, Saraiva, Sereijo and Levy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2022-01-07T15:42:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/50742 |
url |
http://hdl.handle.net/10451/50742 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Front Psychiatry. 2021 Dec 16;12:788281 10.3389/fpsyt.2021.788281 1664-0640 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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Frontiers |
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Frontiers |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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