Antimalarial treatment in infants

Detalhes bibliográficos
Autor(a) principal: Kalkman, Laura C.
Data de Publicação: 2022
Outros Autores: Hanscheid, Thomas, Krishna, Sanjeev, Kremsner, Peter G., Grobusch, Martin P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/55726
Resumo: © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way
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oai_identifier_str oai:repositorio.ul.pt:10451/55726
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spelling Antimalarial treatment in infantsMalariaInfantsPharmacodynamicsPharmacokineticsTreatment© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any wayIntroduction: Malaria in infants is common in high-transmission settings, especially in infants >6 months. Infants undergo physiological changes impacting pharmacokinetics and pharmacodynamics of anti-malarial drugs and, consequently, the safety and efficacy of malaria treatment. Yet, treatment guidelines and evidence on pharmacological interventions for malaria often fail to address this vulnerable age group. This review aims to summarize the available data on anti-malarial treatment in infants. Areas covered: The standard recommended treatments for severe and uncomplicated malaria are generally safe and effective in infants. However, infants have an increased risk of drug-related vomiting and have distinct pharmacokinetic parameters of antimalarials compared with older patients. These include larger volumes of distribution, higher clearance rates, and immature enzyme systems. Consequently, infants with malaria may be at increased risk of treatment failure and drug toxicity. Expert opinion: Knowledge expansion to optimize treatment can be achieved by including more infants in antimalarial drug trials and by reporting separately on treatment outcomes in infants. Additional evidence on the efficacy, safety, tolerability, acceptability, and effectiveness of ACTs in infants is needed, as well as population pharmacokinetics studies on antimalarials in the infant population.Taylor & FrancisRepositório da Universidade de LisboaKalkman, Laura C.Hanscheid, ThomasKrishna, SanjeevKremsner, Peter G.Grobusch, Martin P.2023-01-09T14:35:05Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55726engExpert Opin Pharmacother. 2022 Oct;23(15):1711-17261465-656610.1080/14656566.2022.21306871744-7666info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:18:38Zoai:repositorio.ul.pt:10451/55726Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:18:38Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antimalarial treatment in infants
title Antimalarial treatment in infants
spellingShingle Antimalarial treatment in infants
Kalkman, Laura C.
Malaria
Infants
Pharmacodynamics
Pharmacokinetics
Treatment
title_short Antimalarial treatment in infants
title_full Antimalarial treatment in infants
title_fullStr Antimalarial treatment in infants
title_full_unstemmed Antimalarial treatment in infants
title_sort Antimalarial treatment in infants
author Kalkman, Laura C.
author_facet Kalkman, Laura C.
Hanscheid, Thomas
Krishna, Sanjeev
Kremsner, Peter G.
Grobusch, Martin P.
author_role author
author2 Hanscheid, Thomas
Krishna, Sanjeev
Kremsner, Peter G.
Grobusch, Martin P.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Kalkman, Laura C.
Hanscheid, Thomas
Krishna, Sanjeev
Kremsner, Peter G.
Grobusch, Martin P.
dc.subject.por.fl_str_mv Malaria
Infants
Pharmacodynamics
Pharmacokinetics
Treatment
topic Malaria
Infants
Pharmacodynamics
Pharmacokinetics
Treatment
description © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-01-09T14:35:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/55726
url http://hdl.handle.net/10451/55726
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Expert Opin Pharmacother. 2022 Oct;23(15):1711-1726
1465-6566
10.1080/14656566.2022.2130687
1744-7666
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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