Echocardiographic assessment of cardiac anatomy and function in adult rats

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Sónia
Data de Publicação: 2019
Outros Autores: Pereira, Ana Rita S., Pinto, Ana Teresa, Rocha, Filipe, Ministro, Augusto, Fiuza, Manuela, Pinto, Fausto J., Santos, Susana Constantino Rosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50329
Resumo: Copyright © 2019 Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
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spelling Echocardiographic assessment of cardiac anatomy and function in adult ratsEchocardiographyWistar ratCardiac anatomyCardiac functionHeart valvesDiastolic functionSystolic function2D-EchoDopplerCopyright © 2019 Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported LicenseThe use of experimental animal models has become crucial in cardiovascular science. Most studies using rodent models are focused on two-dimensional imaging to study the cardiac anatomy of the left ventricle and M-mode echo to assess its dimensions. However, this could limit a comprehensive study. Herein, we describe a protocol that allows an assessment of the heart chamber size, left ventricular function (systolic and diastolic) and valvular function. A conventional medical ultrasound machine was used in this protocol and different echo views were obtained through left parasternal, apical and suprasternal windows. In the left parasternal window, the long and short axis were acquired to analyze left chamber dimensions, right ventricle and pulmonary artery dimensions, and mitral, pulmonary and aortic valve function. The apical window allows the measurement of heart chamber dimensions and evaluation of systolic and diastolic parameters. It also allows Doppler assessment with detection and quantification of heart valve disturbances (regurgitation or stenosis). Different segments and walls of the left ventricle are visualized throughout all views. Finally, the ascending aorta, aortic arch, and descending aorta can be imaged through the suprasternal window. A combination of ultrasound imaging, Doppler flow and tissue Doppler assessment have been obtained to study cardiac morphology and function. This represents an important contribution to improve the assessment of cardiac function in adult rats with impact for research using these animal models.MyJoVE CorporationRepositório da Universidade de LisboaRibeiro, SóniaPereira, Ana Rita S.Pinto, Ana TeresaRocha, FilipeMinistro, AugustoFiuza, ManuelaPinto, Fausto J.Santos, Susana Constantino Rosa2021-12-10T13:45:50Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50329engJ Vis Exp. 2019 Dec 13;(154)10.3791/604041940-087Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:27Zoai:repositorio.ul.pt:10451/50329Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:48.639591Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Echocardiographic assessment of cardiac anatomy and function in adult rats
title Echocardiographic assessment of cardiac anatomy and function in adult rats
spellingShingle Echocardiographic assessment of cardiac anatomy and function in adult rats
Ribeiro, Sónia
Echocardiography
Wistar rat
Cardiac anatomy
Cardiac function
Heart valves
Diastolic function
Systolic function
2D-Echo
Doppler
title_short Echocardiographic assessment of cardiac anatomy and function in adult rats
title_full Echocardiographic assessment of cardiac anatomy and function in adult rats
title_fullStr Echocardiographic assessment of cardiac anatomy and function in adult rats
title_full_unstemmed Echocardiographic assessment of cardiac anatomy and function in adult rats
title_sort Echocardiographic assessment of cardiac anatomy and function in adult rats
author Ribeiro, Sónia
author_facet Ribeiro, Sónia
Pereira, Ana Rita S.
Pinto, Ana Teresa
Rocha, Filipe
Ministro, Augusto
Fiuza, Manuela
Pinto, Fausto J.
Santos, Susana Constantino Rosa
author_role author
author2 Pereira, Ana Rita S.
Pinto, Ana Teresa
Rocha, Filipe
Ministro, Augusto
Fiuza, Manuela
Pinto, Fausto J.
Santos, Susana Constantino Rosa
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Ribeiro, Sónia
Pereira, Ana Rita S.
Pinto, Ana Teresa
Rocha, Filipe
Ministro, Augusto
Fiuza, Manuela
Pinto, Fausto J.
Santos, Susana Constantino Rosa
dc.subject.por.fl_str_mv Echocardiography
Wistar rat
Cardiac anatomy
Cardiac function
Heart valves
Diastolic function
Systolic function
2D-Echo
Doppler
topic Echocardiography
Wistar rat
Cardiac anatomy
Cardiac function
Heart valves
Diastolic function
Systolic function
2D-Echo
Doppler
description Copyright © 2019 Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2021-12-10T13:45:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50329
url http://hdl.handle.net/10451/50329
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Vis Exp. 2019 Dec 13;(154)
10.3791/60404
1940-087X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MyJoVE Corporation
publisher.none.fl_str_mv MyJoVE Corporation
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134566723616768

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