Whipple's disease--a challenging diagnosis.

Detalhes bibliográficos
Autor(a) principal: Carneiro, Ana C
Data de Publicação: 2004
Outros Autores: Lima, Palmira, Barbosa, Isabel P, Chaves, F Carneiro
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1117
Resumo: Whipple's Disease is a rare multisystemic disease caused by Gram-positive bacillus, Tropheryma whippelii, family of Actinobacterias and group of Actinomycetes. Because the disease is rare and has different forms of presentation the diagnosis comes frequently late. The authors present the case of a white man, 50 years old, admitted with a clinical picture characterized by weight loss, abdominal pain, ascites, diarrhea. He suffered of arthralgias for four years. The diagnosis was made by biopsy of mesenteric adenopathies and liver, during the laparotomy. The biopsy specimens showed numerous aggregates of foamy macrophages containing granular periodic acid-shiff (PAS)--positive material, diastase resistant. Afterwards, the bacillus was identified by electronic microscopy. The patient was treated with trimethoprim-sulfamethoxazole. Symptoms disappeared and biological values returned to normal. The authors present the case and discuss auxiliary exams, differential diagnosis, follow-up, treatment and review the main characteristics of the disease.
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spelling Whipple's disease--a challenging diagnosis.Doença de Whipple--um desafio diagnóstico.Whipple's Disease is a rare multisystemic disease caused by Gram-positive bacillus, Tropheryma whippelii, family of Actinobacterias and group of Actinomycetes. Because the disease is rare and has different forms of presentation the diagnosis comes frequently late. The authors present the case of a white man, 50 years old, admitted with a clinical picture characterized by weight loss, abdominal pain, ascites, diarrhea. He suffered of arthralgias for four years. The diagnosis was made by biopsy of mesenteric adenopathies and liver, during the laparotomy. The biopsy specimens showed numerous aggregates of foamy macrophages containing granular periodic acid-shiff (PAS)--positive material, diastase resistant. Afterwards, the bacillus was identified by electronic microscopy. The patient was treated with trimethoprim-sulfamethoxazole. Symptoms disappeared and biological values returned to normal. The authors present the case and discuss auxiliary exams, differential diagnosis, follow-up, treatment and review the main characteristics of the disease.Whipple's Disease is a rare multisystemic disease caused by Gram-positive bacillus, Tropheryma whippelii, family of Actinobacterias and group of Actinomycetes. Because the disease is rare and has different forms of presentation the diagnosis comes frequently late. The authors present the case of a white man, 50 years old, admitted with a clinical picture characterized by weight loss, abdominal pain, ascites, diarrhea. He suffered of arthralgias for four years. The diagnosis was made by biopsy of mesenteric adenopathies and liver, during the laparotomy. The biopsy specimens showed numerous aggregates of foamy macrophages containing granular periodic acid-shiff (PAS)--positive material, diastase resistant. Afterwards, the bacillus was identified by electronic microscopy. The patient was treated with trimethoprim-sulfamethoxazole. Symptoms disappeared and biological values returned to normal. The authors present the case and discuss auxiliary exams, differential diagnosis, follow-up, treatment and review the main characteristics of the disease.Ordem dos Médicos2004-12-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1117oai:ojs.www.actamedicaportuguesa.com:article/1117Acta Médica Portuguesa; Vol. 17 No. 6 (2004): November-December; 481-486Acta Médica Portuguesa; Vol. 17 N.º 6 (2004): Novembro-Dezembro; 481-4861646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1117https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1117/782Carneiro, Ana CLima, PalmiraBarbosa, Isabel PChaves, F Carneiroinfo:eu-repo/semantics/openAccess2022-12-20T10:57:29Zoai:ojs.www.actamedicaportuguesa.com:article/1117Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:16:58.707592Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Whipple's disease--a challenging diagnosis.
Doença de Whipple--um desafio diagnóstico.
title Whipple's disease--a challenging diagnosis.
spellingShingle Whipple's disease--a challenging diagnosis.
Carneiro, Ana C
title_short Whipple's disease--a challenging diagnosis.
title_full Whipple's disease--a challenging diagnosis.
title_fullStr Whipple's disease--a challenging diagnosis.
title_full_unstemmed Whipple's disease--a challenging diagnosis.
title_sort Whipple's disease--a challenging diagnosis.
author Carneiro, Ana C
author_facet Carneiro, Ana C
Lima, Palmira
Barbosa, Isabel P
Chaves, F Carneiro
author_role author
author2 Lima, Palmira
Barbosa, Isabel P
Chaves, F Carneiro
author2_role author
author
author
dc.contributor.author.fl_str_mv Carneiro, Ana C
Lima, Palmira
Barbosa, Isabel P
Chaves, F Carneiro
description Whipple's Disease is a rare multisystemic disease caused by Gram-positive bacillus, Tropheryma whippelii, family of Actinobacterias and group of Actinomycetes. Because the disease is rare and has different forms of presentation the diagnosis comes frequently late. The authors present the case of a white man, 50 years old, admitted with a clinical picture characterized by weight loss, abdominal pain, ascites, diarrhea. He suffered of arthralgias for four years. The diagnosis was made by biopsy of mesenteric adenopathies and liver, during the laparotomy. The biopsy specimens showed numerous aggregates of foamy macrophages containing granular periodic acid-shiff (PAS)--positive material, diastase resistant. Afterwards, the bacillus was identified by electronic microscopy. The patient was treated with trimethoprim-sulfamethoxazole. Symptoms disappeared and biological values returned to normal. The authors present the case and discuss auxiliary exams, differential diagnosis, follow-up, treatment and review the main characteristics of the disease.
publishDate 2004
dc.date.none.fl_str_mv 2004-12-31
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dc.language.iso.fl_str_mv por
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1117/782
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 17 No. 6 (2004): November-December; 481-486
Acta Médica Portuguesa; Vol. 17 N.º 6 (2004): Novembro-Dezembro; 481-486
1646-0758
0870-399X
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