Zika virus threshold determines transmission by European Aedes albopictus mosquitoes

Detalhes bibliográficos
Autor(a) principal: Vazeille, Marie
Data de Publicação: 2019
Outros Autores: Madec, Yoann, Mousson, Laurence, Bellone, Rachel, Barré-Cardi, Hélène, Sousa, Carla Alexandra, Jiolle, Davy, Yébakima, André, de Lamballerie, Xavier, Failloux, Anna Bella
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/116763
Resumo: Since its emergence in Yap Island in 2007, Zika virus (ZIKV) has affected all continents except Europe. Despite the hundreds of cases imported to European countries from ZIKV-infested regions, no local cases have been reported in localities where the ZIKV-competent mosquito Aedes albopictus is well established. Here we analysed the vector competence of European Aedes (aegypti and albopictus) mosquitoes to different genotypes of ZIKV. We demonstrate that Ae. albopictus from France was less susceptible to the Asian ZIKV than to the African ZIKV. Critically we show that effective crossing of anatomical barriers (midgut and salivary glands) after an infectious blood meal depends on a viral load threshold to trigger: (i) viral dissemination from the midgut to infect mosquito internal organs and (ii) viral transmission from the saliva to infect a vertebrate host. A viral load in body ≥4800 viral copies triggered dissemination and ≥12,000 viral copies set out transmission. Only 27.3% and 18.2% of Ae. albopictus Montpellier mosquitoes meet respectively these two criteria. Collectively, these compelling results stress the poor ability of Ae. albopictus to sustain a local transmission of ZIKV in Europe and provide a promising tool to evaluate the risk of ZIKV transmission in future outbreaks.
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spelling Zika virus threshold determines transmission by European Aedes albopictus mosquitoesAedes albopictusarbovirusepidemic potentialEuropeZikaEpidemiologyVirologyInfectious DiseasesInsect ScienceSDG 3 - Good Health and Well-beingSince its emergence in Yap Island in 2007, Zika virus (ZIKV) has affected all continents except Europe. Despite the hundreds of cases imported to European countries from ZIKV-infested regions, no local cases have been reported in localities where the ZIKV-competent mosquito Aedes albopictus is well established. Here we analysed the vector competence of European Aedes (aegypti and albopictus) mosquitoes to different genotypes of ZIKV. We demonstrate that Ae. albopictus from France was less susceptible to the Asian ZIKV than to the African ZIKV. Critically we show that effective crossing of anatomical barriers (midgut and salivary glands) after an infectious blood meal depends on a viral load threshold to trigger: (i) viral dissemination from the midgut to infect mosquito internal organs and (ii) viral transmission from the saliva to infect a vertebrate host. A viral load in body ≥4800 viral copies triggered dissemination and ≥12,000 viral copies set out transmission. Only 27.3% and 18.2% of Ae. albopictus Montpellier mosquitoes meet respectively these two criteria. Collectively, these compelling results stress the poor ability of Ae. albopictus to sustain a local transmission of ZIKV in Europe and provide a promising tool to evaluate the risk of ZIKV transmission in future outbreaks.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Vector borne diseases and pathogens (VBD)RUNVazeille, MarieMadec, YoannMousson, LaurenceBellone, RachelBarré-Cardi, HélèneSousa, Carla AlexandraJiolle, DavyYébakima, Andréde Lamballerie, XavierFailloux, Anna Bella2021-05-02T22:52:09Z2019-01-012019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/116763engPURE: 27775795https://doi.org/10.1080/22221751.2019.1689797info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:59:31Zoai:run.unl.pt:10362/116763Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:16.341226Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Zika virus threshold determines transmission by European Aedes albopictus mosquitoes
title Zika virus threshold determines transmission by European Aedes albopictus mosquitoes
spellingShingle Zika virus threshold determines transmission by European Aedes albopictus mosquitoes
Vazeille, Marie
Aedes albopictus
arbovirus
epidemic potential
Europe
Zika
Epidemiology
Virology
Infectious Diseases
Insect Science
SDG 3 - Good Health and Well-being
title_short Zika virus threshold determines transmission by European Aedes albopictus mosquitoes
title_full Zika virus threshold determines transmission by European Aedes albopictus mosquitoes
title_fullStr Zika virus threshold determines transmission by European Aedes albopictus mosquitoes
title_full_unstemmed Zika virus threshold determines transmission by European Aedes albopictus mosquitoes
title_sort Zika virus threshold determines transmission by European Aedes albopictus mosquitoes
author Vazeille, Marie
author_facet Vazeille, Marie
Madec, Yoann
Mousson, Laurence
Bellone, Rachel
Barré-Cardi, Hélène
Sousa, Carla Alexandra
Jiolle, Davy
Yébakima, André
de Lamballerie, Xavier
Failloux, Anna Bella
author_role author
author2 Madec, Yoann
Mousson, Laurence
Bellone, Rachel
Barré-Cardi, Hélène
Sousa, Carla Alexandra
Jiolle, Davy
Yébakima, André
de Lamballerie, Xavier
Failloux, Anna Bella
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
Global Health and Tropical Medicine (GHTM)
Vector borne diseases and pathogens (VBD)
RUN
dc.contributor.author.fl_str_mv Vazeille, Marie
Madec, Yoann
Mousson, Laurence
Bellone, Rachel
Barré-Cardi, Hélène
Sousa, Carla Alexandra
Jiolle, Davy
Yébakima, André
de Lamballerie, Xavier
Failloux, Anna Bella
dc.subject.por.fl_str_mv Aedes albopictus
arbovirus
epidemic potential
Europe
Zika
Epidemiology
Virology
Infectious Diseases
Insect Science
SDG 3 - Good Health and Well-being
topic Aedes albopictus
arbovirus
epidemic potential
Europe
Zika
Epidemiology
Virology
Infectious Diseases
Insect Science
SDG 3 - Good Health and Well-being
description Since its emergence in Yap Island in 2007, Zika virus (ZIKV) has affected all continents except Europe. Despite the hundreds of cases imported to European countries from ZIKV-infested regions, no local cases have been reported in localities where the ZIKV-competent mosquito Aedes albopictus is well established. Here we analysed the vector competence of European Aedes (aegypti and albopictus) mosquitoes to different genotypes of ZIKV. We demonstrate that Ae. albopictus from France was less susceptible to the Asian ZIKV than to the African ZIKV. Critically we show that effective crossing of anatomical barriers (midgut and salivary glands) after an infectious blood meal depends on a viral load threshold to trigger: (i) viral dissemination from the midgut to infect mosquito internal organs and (ii) viral transmission from the saliva to infect a vertebrate host. A viral load in body ≥4800 viral copies triggered dissemination and ≥12,000 viral copies set out transmission. Only 27.3% and 18.2% of Ae. albopictus Montpellier mosquitoes meet respectively these two criteria. Collectively, these compelling results stress the poor ability of Ae. albopictus to sustain a local transmission of ZIKV in Europe and provide a promising tool to evaluate the risk of ZIKV transmission in future outbreaks.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
2019-01-01T00:00:00Z
2021-05-02T22:52:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/116763
url http://hdl.handle.net/10362/116763
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PURE: 27775795
https://doi.org/10.1080/22221751.2019.1689797
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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