Zika virus threshold determines transmission by European Aedes albopictus mosquitoes
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/116763 |
Resumo: | Since its emergence in Yap Island in 2007, Zika virus (ZIKV) has affected all continents except Europe. Despite the hundreds of cases imported to European countries from ZIKV-infested regions, no local cases have been reported in localities where the ZIKV-competent mosquito Aedes albopictus is well established. Here we analysed the vector competence of European Aedes (aegypti and albopictus) mosquitoes to different genotypes of ZIKV. We demonstrate that Ae. albopictus from France was less susceptible to the Asian ZIKV than to the African ZIKV. Critically we show that effective crossing of anatomical barriers (midgut and salivary glands) after an infectious blood meal depends on a viral load threshold to trigger: (i) viral dissemination from the midgut to infect mosquito internal organs and (ii) viral transmission from the saliva to infect a vertebrate host. A viral load in body ≥4800 viral copies triggered dissemination and ≥12,000 viral copies set out transmission. Only 27.3% and 18.2% of Ae. albopictus Montpellier mosquitoes meet respectively these two criteria. Collectively, these compelling results stress the poor ability of Ae. albopictus to sustain a local transmission of ZIKV in Europe and provide a promising tool to evaluate the risk of ZIKV transmission in future outbreaks. |
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Zika virus threshold determines transmission by European Aedes albopictus mosquitoesAedes albopictusarbovirusepidemic potentialEuropeZikaEpidemiologyVirologyInfectious DiseasesInsect ScienceSDG 3 - Good Health and Well-beingSince its emergence in Yap Island in 2007, Zika virus (ZIKV) has affected all continents except Europe. Despite the hundreds of cases imported to European countries from ZIKV-infested regions, no local cases have been reported in localities where the ZIKV-competent mosquito Aedes albopictus is well established. Here we analysed the vector competence of European Aedes (aegypti and albopictus) mosquitoes to different genotypes of ZIKV. We demonstrate that Ae. albopictus from France was less susceptible to the Asian ZIKV than to the African ZIKV. Critically we show that effective crossing of anatomical barriers (midgut and salivary glands) after an infectious blood meal depends on a viral load threshold to trigger: (i) viral dissemination from the midgut to infect mosquito internal organs and (ii) viral transmission from the saliva to infect a vertebrate host. A viral load in body ≥4800 viral copies triggered dissemination and ≥12,000 viral copies set out transmission. Only 27.3% and 18.2% of Ae. albopictus Montpellier mosquitoes meet respectively these two criteria. Collectively, these compelling results stress the poor ability of Ae. albopictus to sustain a local transmission of ZIKV in Europe and provide a promising tool to evaluate the risk of ZIKV transmission in future outbreaks.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Vector borne diseases and pathogens (VBD)RUNVazeille, MarieMadec, YoannMousson, LaurenceBellone, RachelBarré-Cardi, HélèneSousa, Carla AlexandraJiolle, DavyYébakima, Andréde Lamballerie, XavierFailloux, Anna Bella2021-05-02T22:52:09Z2019-01-012019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/116763engPURE: 27775795https://doi.org/10.1080/22221751.2019.1689797info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:59:31Zoai:run.unl.pt:10362/116763Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:16.341226Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Zika virus threshold determines transmission by European Aedes albopictus mosquitoes |
title |
Zika virus threshold determines transmission by European Aedes albopictus mosquitoes |
spellingShingle |
Zika virus threshold determines transmission by European Aedes albopictus mosquitoes Vazeille, Marie Aedes albopictus arbovirus epidemic potential Europe Zika Epidemiology Virology Infectious Diseases Insect Science SDG 3 - Good Health and Well-being |
title_short |
Zika virus threshold determines transmission by European Aedes albopictus mosquitoes |
title_full |
Zika virus threshold determines transmission by European Aedes albopictus mosquitoes |
title_fullStr |
Zika virus threshold determines transmission by European Aedes albopictus mosquitoes |
title_full_unstemmed |
Zika virus threshold determines transmission by European Aedes albopictus mosquitoes |
title_sort |
Zika virus threshold determines transmission by European Aedes albopictus mosquitoes |
author |
Vazeille, Marie |
author_facet |
Vazeille, Marie Madec, Yoann Mousson, Laurence Bellone, Rachel Barré-Cardi, Hélène Sousa, Carla Alexandra Jiolle, Davy Yébakima, André de Lamballerie, Xavier Failloux, Anna Bella |
author_role |
author |
author2 |
Madec, Yoann Mousson, Laurence Bellone, Rachel Barré-Cardi, Hélène Sousa, Carla Alexandra Jiolle, Davy Yébakima, André de Lamballerie, Xavier Failloux, Anna Bella |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) Vector borne diseases and pathogens (VBD) RUN |
dc.contributor.author.fl_str_mv |
Vazeille, Marie Madec, Yoann Mousson, Laurence Bellone, Rachel Barré-Cardi, Hélène Sousa, Carla Alexandra Jiolle, Davy Yébakima, André de Lamballerie, Xavier Failloux, Anna Bella |
dc.subject.por.fl_str_mv |
Aedes albopictus arbovirus epidemic potential Europe Zika Epidemiology Virology Infectious Diseases Insect Science SDG 3 - Good Health and Well-being |
topic |
Aedes albopictus arbovirus epidemic potential Europe Zika Epidemiology Virology Infectious Diseases Insect Science SDG 3 - Good Health and Well-being |
description |
Since its emergence in Yap Island in 2007, Zika virus (ZIKV) has affected all continents except Europe. Despite the hundreds of cases imported to European countries from ZIKV-infested regions, no local cases have been reported in localities where the ZIKV-competent mosquito Aedes albopictus is well established. Here we analysed the vector competence of European Aedes (aegypti and albopictus) mosquitoes to different genotypes of ZIKV. We demonstrate that Ae. albopictus from France was less susceptible to the Asian ZIKV than to the African ZIKV. Critically we show that effective crossing of anatomical barriers (midgut and salivary glands) after an infectious blood meal depends on a viral load threshold to trigger: (i) viral dissemination from the midgut to infect mosquito internal organs and (ii) viral transmission from the saliva to infect a vertebrate host. A viral load in body ≥4800 viral copies triggered dissemination and ≥12,000 viral copies set out transmission. Only 27.3% and 18.2% of Ae. albopictus Montpellier mosquitoes meet respectively these two criteria. Collectively, these compelling results stress the poor ability of Ae. albopictus to sustain a local transmission of ZIKV in Europe and provide a promising tool to evaluate the risk of ZIKV transmission in future outbreaks. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 2019-01-01T00:00:00Z 2021-05-02T22:52:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/116763 |
url |
http://hdl.handle.net/10362/116763 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PURE: 27775795 https://doi.org/10.1080/22221751.2019.1689797 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
11 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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