Tubulointerstitial nephritis and uveitis syndrome (TINU) - à propos of 2 cases

• Autor(a) principal: Macau,Ricardo A
• Data de Publicação: 2018
• Outros Autores: Barreto,Sara, Martins,Joana, Silva,Joana, Fraga,Filipe, Manso,Rita T, Bravo,Pedro, Ramos,Aura
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000200010
• topic: Immunosuppression; Interstitial nephritis; Steroids; Tubulointerstitial nephritis and uveitis; Uveitis

The authors present two cases of tubulointerstitial nephritis and uveitis syndrome (TINU). TINU is a well-known yet rarely reported oculorenal inflammatory clinical entity. A high level of suspicion is needed to identify this entity. The first case is that of a 24-year-old female presenting with bilateral red eye and ocular pain. Laboratory investigation revealed renal insufficiency (serum creatinine 4.9mg/dL) and kidney biopsy presented tubulointerstitial nephritis. The second case is that of a 69-year-old female initially diagnosed with uveitis who later presented with general symptoms and renal insufficiency (serum creatinine 3.96 mg/dL) and whose kidney biopsy showed a tubulointerstitial nephritis pattern. Both patients were treated with steroids and renal function improved. It may be worth screening for uveitis in all patients with tubulointerstitial nephritis and evaluating renal function in those presenting with apparent idiopathic uveitis.