Cytohistological correlation in pleural effusions based on the international system for reporting serous fluid cytopathology
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/121377 |
Resumo: | The International System for Reporting Serous Fluid Cytology (TIS) was recently developed. Given its novelty, most studies looking into the risk of malignancy (ROM) of serous effusion diagnostic categories were published before the development of TIS. We searched the database of our department for pleural effusions diagnosed in the last five years, excluding those without a corresponding pleural biopsy. Cases were reviewed and reclassified according to the TIS. A cytohistological correlation was performed. In total, 350 pleural effusion specimens with one or more corresponding pleural biopsies were included. After reclassification, 5 (1.43%) were nondiagnostic (ND), 253 (72.29%) were negative for malignancy (NFM), 7 (2.00%) had atypia of unknown significance (AUS), 14 (4.00%) were suspicious for malignancy (SFM), and 71 (20.57%) were malignant (MAL). Calculated ROM was 40% for ND, 20.16% for NFM, 42.86% for AUS, 78.57% for SFM, and 100% for MAL. Effusion cytology sensitivity and specificity were 60.29% and 98.56%, respectively. This is the first publication looking into the cytohistological correlation of a retrospective cohort of pleural effusions based on the TIS. We add to the body of data regarding the ROM for TIS categories, highlighting areas of potential future research. |
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Cytohistological correlation in pleural effusions based on the international system for reporting serous fluid cytopathologyCytologyEffusionInternational systemMolecular pathologySerousStandardizationClinical BiochemistryThe International System for Reporting Serous Fluid Cytology (TIS) was recently developed. Given its novelty, most studies looking into the risk of malignancy (ROM) of serous effusion diagnostic categories were published before the development of TIS. We searched the database of our department for pleural effusions diagnosed in the last five years, excluding those without a corresponding pleural biopsy. Cases were reviewed and reclassified according to the TIS. A cytohistological correlation was performed. In total, 350 pleural effusion specimens with one or more corresponding pleural biopsies were included. After reclassification, 5 (1.43%) were nondiagnostic (ND), 253 (72.29%) were negative for malignancy (NFM), 7 (2.00%) had atypia of unknown significance (AUS), 14 (4.00%) were suspicious for malignancy (SFM), and 71 (20.57%) were malignant (MAL). Calculated ROM was 40% for ND, 20.16% for NFM, 42.86% for AUS, 78.57% for SFM, and 100% for MAL. Effusion cytology sensitivity and specificity were 60.29% and 98.56%, respectively. This is the first publication looking into the cytohistological correlation of a retrospective cohort of pleural effusions based on the TIS. We add to the body of data regarding the ROM for TIS categories, highlighting areas of potential future research.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNPinto, DanielCruz, EduardoBranco, DiamantinaLinares, CláudiaCarvalho, ConceiçãoSilva, AméliaChorão, MartinhaSchmitt, Fernando2021-07-20T22:19:59Z2021-062021-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/121377eng2075-4418PURE: 32498197https://doi.org/10.3390/diagnostics11061126info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:03:40Zoai:run.unl.pt:10362/121377Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:44:35.396348Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cytohistological correlation in pleural effusions based on the international system for reporting serous fluid cytopathology |
title |
Cytohistological correlation in pleural effusions based on the international system for reporting serous fluid cytopathology |
spellingShingle |
Cytohistological correlation in pleural effusions based on the international system for reporting serous fluid cytopathology Pinto, Daniel Cytology Effusion International system Molecular pathology Serous Standardization Clinical Biochemistry |
title_short |
Cytohistological correlation in pleural effusions based on the international system for reporting serous fluid cytopathology |
title_full |
Cytohistological correlation in pleural effusions based on the international system for reporting serous fluid cytopathology |
title_fullStr |
Cytohistological correlation in pleural effusions based on the international system for reporting serous fluid cytopathology |
title_full_unstemmed |
Cytohistological correlation in pleural effusions based on the international system for reporting serous fluid cytopathology |
title_sort |
Cytohistological correlation in pleural effusions based on the international system for reporting serous fluid cytopathology |
author |
Pinto, Daniel |
author_facet |
Pinto, Daniel Cruz, Eduardo Branco, Diamantina Linares, Cláudia Carvalho, Conceição Silva, Amélia Chorão, Martinha Schmitt, Fernando |
author_role |
author |
author2 |
Cruz, Eduardo Branco, Diamantina Linares, Cláudia Carvalho, Conceição Silva, Amélia Chorão, Martinha Schmitt, Fernando |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Pinto, Daniel Cruz, Eduardo Branco, Diamantina Linares, Cláudia Carvalho, Conceição Silva, Amélia Chorão, Martinha Schmitt, Fernando |
dc.subject.por.fl_str_mv |
Cytology Effusion International system Molecular pathology Serous Standardization Clinical Biochemistry |
topic |
Cytology Effusion International system Molecular pathology Serous Standardization Clinical Biochemistry |
description |
The International System for Reporting Serous Fluid Cytology (TIS) was recently developed. Given its novelty, most studies looking into the risk of malignancy (ROM) of serous effusion diagnostic categories were published before the development of TIS. We searched the database of our department for pleural effusions diagnosed in the last five years, excluding those without a corresponding pleural biopsy. Cases were reviewed and reclassified according to the TIS. A cytohistological correlation was performed. In total, 350 pleural effusion specimens with one or more corresponding pleural biopsies were included. After reclassification, 5 (1.43%) were nondiagnostic (ND), 253 (72.29%) were negative for malignancy (NFM), 7 (2.00%) had atypia of unknown significance (AUS), 14 (4.00%) were suspicious for malignancy (SFM), and 71 (20.57%) were malignant (MAL). Calculated ROM was 40% for ND, 20.16% for NFM, 42.86% for AUS, 78.57% for SFM, and 100% for MAL. Effusion cytology sensitivity and specificity were 60.29% and 98.56%, respectively. This is the first publication looking into the cytohistological correlation of a retrospective cohort of pleural effusions based on the TIS. We add to the body of data regarding the ROM for TIS categories, highlighting areas of potential future research. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-20T22:19:59Z 2021-06 2021-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/121377 |
url |
http://hdl.handle.net/10362/121377 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2075-4418 PURE: 32498197 https://doi.org/10.3390/diagnostics11061126 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799138053310119936 |