Efficacy and safety of diltiazem in the treatment of arterial hypertension in the elderly.
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1767 |
Resumo: | A multicentric, non-comparative study was made to evaluate the efficacy and safety of diltiazem 180 mg in the elderly, with dose titration in subjects above the age of 60 years. The blood pressure measurements were done by ambulatory blood pressure monitoring (ABPM). We achieved a reduction of at least 10 mmHg in systolic blood pressure in 52.2% and in diastolic blood pressure in 42.5% of the patients. The estimated differences between the initial values and those after treatment are 30% (CI95%: 22-38%) for diurnal blood pressure load, 22% (CI95%: 14-29%) for nocturnal blood pressure load, 13 mmHg (CI95%: 10-16 mmHg) for median systolic BP, and 8 mmHg (CI95%: 6-10 mmHg) for median diastolic BP. In 62.5% of the subjects the daily dose of diltiazem was increased to 240 mg (180 mg in the morning and 60 mg at night). All the cardiovascular parameters evaluated showed a significant decrease at the end of the study. A significant change was not recorded in the laboratory parameters and the adverse event average was minimal. The results showed that diltiazem in monotherapy is effective in the control of hypertension in the elderly and can improve compliance to the treatment. |
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Efficacy and safety of diltiazem in the treatment of arterial hypertension in the elderly.Eficácia e segurança do Diltiazem no tratamento da hipertensão arterial no idoso.A multicentric, non-comparative study was made to evaluate the efficacy and safety of diltiazem 180 mg in the elderly, with dose titration in subjects above the age of 60 years. The blood pressure measurements were done by ambulatory blood pressure monitoring (ABPM). We achieved a reduction of at least 10 mmHg in systolic blood pressure in 52.2% and in diastolic blood pressure in 42.5% of the patients. The estimated differences between the initial values and those after treatment are 30% (CI95%: 22-38%) for diurnal blood pressure load, 22% (CI95%: 14-29%) for nocturnal blood pressure load, 13 mmHg (CI95%: 10-16 mmHg) for median systolic BP, and 8 mmHg (CI95%: 6-10 mmHg) for median diastolic BP. In 62.5% of the subjects the daily dose of diltiazem was increased to 240 mg (180 mg in the morning and 60 mg at night). All the cardiovascular parameters evaluated showed a significant decrease at the end of the study. A significant change was not recorded in the laboratory parameters and the adverse event average was minimal. The results showed that diltiazem in monotherapy is effective in the control of hypertension in the elderly and can improve compliance to the treatment.A multicentric, non-comparative study was made to evaluate the efficacy and safety of diltiazem 180 mg in the elderly, with dose titration in subjects above the age of 60 years. The blood pressure measurements were done by ambulatory blood pressure monitoring (ABPM). We achieved a reduction of at least 10 mmHg in systolic blood pressure in 52.2% and in diastolic blood pressure in 42.5% of the patients. The estimated differences between the initial values and those after treatment are 30% (CI95%: 22-38%) for diurnal blood pressure load, 22% (CI95%: 14-29%) for nocturnal blood pressure load, 13 mmHg (CI95%: 10-16 mmHg) for median systolic BP, and 8 mmHg (CI95%: 6-10 mmHg) for median diastolic BP. In 62.5% of the subjects the daily dose of diltiazem was increased to 240 mg (180 mg in the morning and 60 mg at night). All the cardiovascular parameters evaluated showed a significant decrease at the end of the study. A significant change was not recorded in the laboratory parameters and the adverse event average was minimal. The results showed that diltiazem in monotherapy is effective in the control of hypertension in the elderly and can improve compliance to the treatment.Ordem dos Médicos2000-04-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1767oai:ojs.www.actamedicaportuguesa.com:article/1767Acta Médica Portuguesa; Vol. 13 No. 1-2 (2000): Janeiro-Abril; 7-12Acta Médica Portuguesa; Vol. 13 N.º 1-2 (2000): Janeiro-Abril; 7-121646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1767https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1767/1344Pêgo, G MDe Carvalho, M JD'Araújo, J ARamalhão, CDa Silva, P Minfo:eu-repo/semantics/openAccess2022-12-20T10:58:58Zoai:ojs.www.actamedicaportuguesa.com:article/1767Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:17:22.776578Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Efficacy and safety of diltiazem in the treatment of arterial hypertension in the elderly. Eficácia e segurança do Diltiazem no tratamento da hipertensão arterial no idoso. |
title |
Efficacy and safety of diltiazem in the treatment of arterial hypertension in the elderly. |
spellingShingle |
Efficacy and safety of diltiazem in the treatment of arterial hypertension in the elderly. Pêgo, G M |
title_short |
Efficacy and safety of diltiazem in the treatment of arterial hypertension in the elderly. |
title_full |
Efficacy and safety of diltiazem in the treatment of arterial hypertension in the elderly. |
title_fullStr |
Efficacy and safety of diltiazem in the treatment of arterial hypertension in the elderly. |
title_full_unstemmed |
Efficacy and safety of diltiazem in the treatment of arterial hypertension in the elderly. |
title_sort |
Efficacy and safety of diltiazem in the treatment of arterial hypertension in the elderly. |
author |
Pêgo, G M |
author_facet |
Pêgo, G M De Carvalho, M J D'Araújo, J A Ramalhão, C Da Silva, P M |
author_role |
author |
author2 |
De Carvalho, M J D'Araújo, J A Ramalhão, C Da Silva, P M |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Pêgo, G M De Carvalho, M J D'Araújo, J A Ramalhão, C Da Silva, P M |
description |
A multicentric, non-comparative study was made to evaluate the efficacy and safety of diltiazem 180 mg in the elderly, with dose titration in subjects above the age of 60 years. The blood pressure measurements were done by ambulatory blood pressure monitoring (ABPM). We achieved a reduction of at least 10 mmHg in systolic blood pressure in 52.2% and in diastolic blood pressure in 42.5% of the patients. The estimated differences between the initial values and those after treatment are 30% (CI95%: 22-38%) for diurnal blood pressure load, 22% (CI95%: 14-29%) for nocturnal blood pressure load, 13 mmHg (CI95%: 10-16 mmHg) for median systolic BP, and 8 mmHg (CI95%: 6-10 mmHg) for median diastolic BP. In 62.5% of the subjects the daily dose of diltiazem was increased to 240 mg (180 mg in the morning and 60 mg at night). All the cardiovascular parameters evaluated showed a significant decrease at the end of the study. A significant change was not recorded in the laboratory parameters and the adverse event average was minimal. The results showed that diltiazem in monotherapy is effective in the control of hypertension in the elderly and can improve compliance to the treatment. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-04-30 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1767 oai:ojs.www.actamedicaportuguesa.com:article/1767 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1767 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/1767 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1767 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1767/1344 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 13 No. 1-2 (2000): Janeiro-Abril; 7-12 Acta Médica Portuguesa; Vol. 13 N.º 1-2 (2000): Janeiro-Abril; 7-12 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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