Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma

Detalhes bibliográficos
Autor(a) principal: Afonso, Julieta Alexandra Pereira
Data de Publicação: 2019
Outros Autores: Pinto, Tatiana, Sousa, Susana Patrícia Simões, Schmitt, Fernando, Longatto, Adhemar, Pinheiro, Céline, Marques, Herlander, Baltazar, Fátima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/62454
Resumo: Increased glycolytic activity with accumulation of extracellular lactate is regarded as a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic value, corroborating that these tumours are avid for glucose. However, the role of glycolytic metabolism-related molecules in lymphoma is not well known. Here, we aimed to evaluate the clinical and prognostic significance of a panel of glycolytic metabolism-related molecules in primary non-Hodgkin lymphomas (NHL) and to test in vitro the putative therapeutic impact of lactate transport inhibition.
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spelling Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphomaNon-Hodgkin lymphomaDiffuse large B cell lymphomaWarburg effectMonocarboxylate transportersMetabolic symbiosisAZD3965Ciências Médicas::Medicina BásicaScience & TechnologyIncreased glycolytic activity with accumulation of extracellular lactate is regarded as a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic value, corroborating that these tumours are avid for glucose. However, the role of glycolytic metabolism-related molecules in lymphoma is not well known. Here, we aimed to evaluate the clinical and prognostic significance of a panel of glycolytic metabolism-related molecules in primary non-Hodgkin lymphomas (NHL) and to test in vitro the putative therapeutic impact of lactate transport inhibition.NORTE-01-0145-FEDER- 000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020) under the Portugal Partnership Agreement, through the European Regional Development Fund (FEDER), and through the Competitiveness Factors Operational Programme (COMPETE) and by National funds, through the Foundation for Science and Technology (FCT), under the scope of project POCI-01-0145-FEDER-007038. JA received a fellowship from FCT, ref. SFRH/BPD/116784/2016Springer VerlagUniversidade do MinhoAfonso, Julieta Alexandra PereiraPinto, TatianaSousa, Susana Patrícia SimõesSchmitt, FernandoLongatto, AdhemarPinheiro, CélineMarques, HerlanderBaltazar, Fátima2019-062019-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62454engAfonso, J., Pinto, T., Simões-Sousa, S., Schmitt, F., Longatto-Filho, A., Pinheiro, C., ... & Baltazar, F. (2019). Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma–MCT1 as potential target in diffuse large B cell lymphoma. Cellular Oncology, 1-162211-34282211-343610.1007/s13402-019-00426-230790227https://link.springer.com/article/10.1007/s13402-019-00426-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:16:15Zoai:repositorium.sdum.uminho.pt:1822/62454Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:08:45.836616Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma
title Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma
spellingShingle Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma
Afonso, Julieta Alexandra Pereira
Non-Hodgkin lymphoma
Diffuse large B cell lymphoma
Warburg effect
Monocarboxylate transporters
Metabolic symbiosis
AZD3965
Ciências Médicas::Medicina Básica
Science & Technology
title_short Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma
title_full Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma
title_fullStr Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma
title_full_unstemmed Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma
title_sort Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma
author Afonso, Julieta Alexandra Pereira
author_facet Afonso, Julieta Alexandra Pereira
Pinto, Tatiana
Sousa, Susana Patrícia Simões
Schmitt, Fernando
Longatto, Adhemar
Pinheiro, Céline
Marques, Herlander
Baltazar, Fátima
author_role author
author2 Pinto, Tatiana
Sousa, Susana Patrícia Simões
Schmitt, Fernando
Longatto, Adhemar
Pinheiro, Céline
Marques, Herlander
Baltazar, Fátima
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Afonso, Julieta Alexandra Pereira
Pinto, Tatiana
Sousa, Susana Patrícia Simões
Schmitt, Fernando
Longatto, Adhemar
Pinheiro, Céline
Marques, Herlander
Baltazar, Fátima
dc.subject.por.fl_str_mv Non-Hodgkin lymphoma
Diffuse large B cell lymphoma
Warburg effect
Monocarboxylate transporters
Metabolic symbiosis
AZD3965
Ciências Médicas::Medicina Básica
Science & Technology
topic Non-Hodgkin lymphoma
Diffuse large B cell lymphoma
Warburg effect
Monocarboxylate transporters
Metabolic symbiosis
AZD3965
Ciências Médicas::Medicina Básica
Science & Technology
description Increased glycolytic activity with accumulation of extracellular lactate is regarded as a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic value, corroborating that these tumours are avid for glucose. However, the role of glycolytic metabolism-related molecules in lymphoma is not well known. Here, we aimed to evaluate the clinical and prognostic significance of a panel of glycolytic metabolism-related molecules in primary non-Hodgkin lymphomas (NHL) and to test in vitro the putative therapeutic impact of lactate transport inhibition.
publishDate 2019
dc.date.none.fl_str_mv 2019-06
2019-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/62454
url http://hdl.handle.net/1822/62454
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Afonso, J., Pinto, T., Simões-Sousa, S., Schmitt, F., Longatto-Filho, A., Pinheiro, C., ... & Baltazar, F. (2019). Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma–MCT1 as potential target in diffuse large B cell lymphoma. Cellular Oncology, 1-16
2211-3428
2211-3436
10.1007/s13402-019-00426-2
30790227
https://link.springer.com/article/10.1007/s13402-019-00426-2
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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