Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration

Detalhes bibliográficos
Autor(a) principal: Chen, Yujie
Data de Publicação: 2021
Outros Autores: Jia, Zihao, Shafiq, Muhammad, Xie, Xianrui, Xiao, Xianghao, Castro, Rita, Rodrigues, João, Wu, Jinglei, Zhou, Guangdong, Mo, Xiumei
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.13/4091
Resumo: Electrospun nanofibers emulate extracellular matrix (ECM) morphology and architecture; however, small pore size and tightly-packed fibers impede their translation in tissue engineering. Here we exploited in situ gas foaming to afford three-dimensional (3D) poly(L-lactide-co-ε-caprolactone)/silk fibroin (PLCL/SF) scaffolds, which exhibited nanotopographic cues and a multilayered structure. The addition of SF improved the hydro philicity and biocompatibility of 3D PLCL scaffolds. Three-dimensional scaffolds exhibited larger pore size (38.75 ± 9.78 μm2 ) and high porosity (87.1% ± 1.5%) than that of their 2D counterparts. 3D scaffolds also improved the deposition of ECM components and neo-vessel regeneration as well as exhibited more numbers of CD163+/ CCR7+ cells after 2 weeks implantation in a subcutaneous model. Collectively, 3D PLCL/SF scaffolds have broad implications for regenerative medicine and tissue engineering applications.
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spelling Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regenerationElectrospun nanofiber scaffoldGas foamingThree-dimensional scaffoldsCell infiltrationTissue engineering.Faculdade de Ciências Exatas e da EngenhariaCentro de Química da MadeiraElectrospun nanofibers emulate extracellular matrix (ECM) morphology and architecture; however, small pore size and tightly-packed fibers impede their translation in tissue engineering. Here we exploited in situ gas foaming to afford three-dimensional (3D) poly(L-lactide-co-ε-caprolactone)/silk fibroin (PLCL/SF) scaffolds, which exhibited nanotopographic cues and a multilayered structure. The addition of SF improved the hydro philicity and biocompatibility of 3D PLCL scaffolds. Three-dimensional scaffolds exhibited larger pore size (38.75 ± 9.78 μm2 ) and high porosity (87.1% ± 1.5%) than that of their 2D counterparts. 3D scaffolds also improved the deposition of ECM components and neo-vessel regeneration as well as exhibited more numbers of CD163+/ CCR7+ cells after 2 weeks implantation in a subcutaneous model. Collectively, 3D PLCL/SF scaffolds have broad implications for regenerative medicine and tissue engineering applications.ElsevierDigitUMaChen, YujieJia, ZihaoShafiq, MuhammadXie, XianruiXiao, XianghaoCastro, RitaRodrigues, JoãoWu, JingleiZhou, GuangdongMo, Xiumei2022-02-18T11:11:02Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.13/4091engChen, Y., Jia, Z., Shafiq, M., Xie, X., Xiao, X., Castro, R., ... & Mo, X. (2021). Gas foaming of electrospun poly (L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration. Colloids and Surfaces B: Biointerfaces, 201, 111637. https://doi.org/10.1016/j.colsurfb.2021.11163710.1016/j.colsurfb.2021.111637info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-17T05:58:06Zoai:digituma.uma.pt:10400.13/4091Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:07:54.990221Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration
title Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration
spellingShingle Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration
Chen, Yujie
Electrospun nanofiber scaffold
Gas foaming
Three-dimensional scaffolds
Cell infiltration
Tissue engineering
.
Faculdade de Ciências Exatas e da Engenharia
Centro de Química da Madeira
title_short Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration
title_full Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration
title_fullStr Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration
title_full_unstemmed Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration
title_sort Gas foaming of electrospun poly(L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration
author Chen, Yujie
author_facet Chen, Yujie
Jia, Zihao
Shafiq, Muhammad
Xie, Xianrui
Xiao, Xianghao
Castro, Rita
Rodrigues, João
Wu, Jinglei
Zhou, Guangdong
Mo, Xiumei
author_role author
author2 Jia, Zihao
Shafiq, Muhammad
Xie, Xianrui
Xiao, Xianghao
Castro, Rita
Rodrigues, João
Wu, Jinglei
Zhou, Guangdong
Mo, Xiumei
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DigitUMa
dc.contributor.author.fl_str_mv Chen, Yujie
Jia, Zihao
Shafiq, Muhammad
Xie, Xianrui
Xiao, Xianghao
Castro, Rita
Rodrigues, João
Wu, Jinglei
Zhou, Guangdong
Mo, Xiumei
dc.subject.por.fl_str_mv Electrospun nanofiber scaffold
Gas foaming
Three-dimensional scaffolds
Cell infiltration
Tissue engineering
.
Faculdade de Ciências Exatas e da Engenharia
Centro de Química da Madeira
topic Electrospun nanofiber scaffold
Gas foaming
Three-dimensional scaffolds
Cell infiltration
Tissue engineering
.
Faculdade de Ciências Exatas e da Engenharia
Centro de Química da Madeira
description Electrospun nanofibers emulate extracellular matrix (ECM) morphology and architecture; however, small pore size and tightly-packed fibers impede their translation in tissue engineering. Here we exploited in situ gas foaming to afford three-dimensional (3D) poly(L-lactide-co-ε-caprolactone)/silk fibroin (PLCL/SF) scaffolds, which exhibited nanotopographic cues and a multilayered structure. The addition of SF improved the hydro philicity and biocompatibility of 3D PLCL scaffolds. Three-dimensional scaffolds exhibited larger pore size (38.75 ± 9.78 μm2 ) and high porosity (87.1% ± 1.5%) than that of their 2D counterparts. 3D scaffolds also improved the deposition of ECM components and neo-vessel regeneration as well as exhibited more numbers of CD163+/ CCR7+ cells after 2 weeks implantation in a subcutaneous model. Collectively, 3D PLCL/SF scaffolds have broad implications for regenerative medicine and tissue engineering applications.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2022-02-18T11:11:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.13/4091
url http://hdl.handle.net/10400.13/4091
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Chen, Y., Jia, Z., Shafiq, M., Xie, X., Xiao, X., Castro, R., ... & Mo, X. (2021). Gas foaming of electrospun poly (L-lactide-co-caprolactone)/silk fibroin nanofiber scaffolds to promote cellular infiltration and tissue regeneration. Colloids and Surfaces B: Biointerfaces, 201, 111637. https://doi.org/10.1016/j.colsurfb.2021.111637
10.1016/j.colsurfb.2021.111637
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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