Marine natural products as anticancer agents 2.0
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.8/8758 |
Resumo: | [Introduction] Global cancer incidence and death are expected to increase to 28.4 million cases by 2040, despite efforts to understand cancer biology better and to improve its diagnosis and therapy [1]. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes [2]. Over the last few decades, the marine environment has become an important source of molecules with potent anticancer properties, exhibiting unusual chemical features and mechanisms of action. Twelve of seventeen drugs of marine origin approved by regulatory entities are used against cancer, and thirty-four of forty compounds in the marine pharmaceuticals pipeline indicate “cancer therapy” [3]. |
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Marine natural products as anticancer agents 2.0Marine natural productsAnticancer agentsSemi-synthesisMetastasisImmunotherapyMechanism of action[Introduction] Global cancer incidence and death are expected to increase to 28.4 million cases by 2040, despite efforts to understand cancer biology better and to improve its diagnosis and therapy [1]. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes [2]. Over the last few decades, the marine environment has become an important source of molecules with potent anticancer properties, exhibiting unusual chemical features and mechanisms of action. Twelve of seventeen drugs of marine origin approved by regulatory entities are used against cancer, and thirty-four of forty compounds in the marine pharmaceuticals pipeline indicate “cancer therapy” [3].Marc Diederich was supported by the National Research Foundation (NRF) by the MEST of Korea for Tumor Microenvironment Global Core Research Center (GCRC) grant (grant number NRF 2011-0030001), by the Seoul National University Research Grant (Funding number: 800-20160150) and by the Creative-Pioneering Researchers Program through Seoul National University (SNU) (Funding number: 370C-20160062). Research at SNU is also supported by the National Research Foundation (NRF) (Grant Number 2022R1A2C101314111). Support from the BrainKorea21 FOUR program is acknowledged. Marc Diederich is supported by the “Recherche Cancer et Sang” foundation, the “Recherches Scientifiques Luxembourg” association, the “Een Häerz fir kriibskrank Kanner” association, the Action LIONS “Vaincre le Cancer” association, and Télévie Luxembourg. C.A. acknowledges the support by the Portuguese Foundation for Science and Technology (FCT) through the Strategic Projects granted to MARE—Marine and Environmental Sciences Centre (UIDP/04292/2020 and UIDB/04292/2020), Associate Laboratory ARNET (LA/P/0069/2020), and through the NEURONS4 (2022.09196.PTDC), MArTics (FCT/DRI/CAPES 2019.00277.CBM) and NEURONS (FCT/DRI/PNAAE 2021.09608.CBM) projects.MDPIIC-OnlineAlves, CelsoDiederich, Marc2023-09-05T11:19:14Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8758engAlves, C.; Diederich, M. Marine Natural Products as Anticancer Agents 2.0. Mar. Drugs 2023, 21, 247. https://doi.org/10.3390/md210402471660-339710.3390/md21040247info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:58:06Zoai:iconline.ipleiria.pt:10400.8/8758Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:24.876788Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Marine natural products as anticancer agents 2.0 |
title |
Marine natural products as anticancer agents 2.0 |
spellingShingle |
Marine natural products as anticancer agents 2.0 Alves, Celso Marine natural products Anticancer agents Semi-synthesis Metastasis Immunotherapy Mechanism of action |
title_short |
Marine natural products as anticancer agents 2.0 |
title_full |
Marine natural products as anticancer agents 2.0 |
title_fullStr |
Marine natural products as anticancer agents 2.0 |
title_full_unstemmed |
Marine natural products as anticancer agents 2.0 |
title_sort |
Marine natural products as anticancer agents 2.0 |
author |
Alves, Celso |
author_facet |
Alves, Celso Diederich, Marc |
author_role |
author |
author2 |
Diederich, Marc |
author2_role |
author |
dc.contributor.none.fl_str_mv |
IC-Online |
dc.contributor.author.fl_str_mv |
Alves, Celso Diederich, Marc |
dc.subject.por.fl_str_mv |
Marine natural products Anticancer agents Semi-synthesis Metastasis Immunotherapy Mechanism of action |
topic |
Marine natural products Anticancer agents Semi-synthesis Metastasis Immunotherapy Mechanism of action |
description |
[Introduction] Global cancer incidence and death are expected to increase to 28.4 million cases by 2040, despite efforts to understand cancer biology better and to improve its diagnosis and therapy [1]. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes [2]. Over the last few decades, the marine environment has become an important source of molecules with potent anticancer properties, exhibiting unusual chemical features and mechanisms of action. Twelve of seventeen drugs of marine origin approved by regulatory entities are used against cancer, and thirty-four of forty compounds in the marine pharmaceuticals pipeline indicate “cancer therapy” [3]. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-05T11:19:14Z 2023 2023-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.8/8758 |
url |
http://hdl.handle.net/10400.8/8758 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Alves, C.; Diederich, M. Marine Natural Products as Anticancer Agents 2.0. Mar. Drugs 2023, 21, 247. https://doi.org/10.3390/md21040247 1660-3397 10.3390/md21040247 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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