Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal

Detalhes bibliográficos
Autor(a) principal: Isidro, Joana
Data de Publicação: 2018
Outros Autores: Santos, Andrea, Nunes, Alexandra, Borges, Vítor, Silva, Catarina, Vieira, Luís, Mendes, Aristides L., Serrano, Mónica, Henriques, Adriano O., Gomes, João Paulo, Oleastro, Mónica
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/6256
Resumo: We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
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spelling Imipenem Resistance in Clostridium difficile Ribotype 017, PortugalAmino Acid SequenceAnti-Bacterial AgentsClostridium difficileEnterocolitis, PseudomembranousGenome, BacterialHumansImipenemMicrobial Sensitivity TestsMutationPhylogenyPortugalWhole Genome SequencingDrug Resistance, BacterialRibotypingInfecções GastrointestinaisWe describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.This work was supported by the National Institute of Health Dr. Ricardo Jorge (grant no. 2016DDI1284). We also acknowledge grant Pest-C/EQB/LA0006/2011 from Fundação para a Ciência e a Tecnologia (FCT; http://www.fct.pt) and program Investigador FCT (IF/00268/2013/CP1173/CT0006 to M.S.). A.L.M. was supported by a PhD fellowship (PD/BD/105738/2014) from the FCT.Centers for Disease Control and PreventionRepositório Científico do Instituto Nacional de SaúdeIsidro, JoanaSantos, AndreaNunes, AlexandraBorges, VítorSilva, CatarinaVieira, LuísMendes, Aristides L.Serrano, MónicaHenriques, Adriano O.Gomes, João PauloOleastro, Mónica2019-03-20T18:11:02Z2018-042018-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6256engEmerg Infect Dis. 2018 Apr;24(4):741-745. doi: 10.3201/eid2404.1700951080-604010.3201/eid2404.170095info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:17Zoai:repositorio.insa.pt:10400.18/6256Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:53.096301Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
title Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
spellingShingle Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
Isidro, Joana
Amino Acid Sequence
Anti-Bacterial Agents
Clostridium difficile
Enterocolitis, Pseudomembranous
Genome, Bacterial
Humans
Imipenem
Microbial Sensitivity Tests
Mutation
Phylogeny
Portugal
Whole Genome Sequencing
Drug Resistance, Bacterial
Ribotyping
Infecções Gastrointestinais
title_short Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
title_full Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
title_fullStr Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
title_full_unstemmed Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
title_sort Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
author Isidro, Joana
author_facet Isidro, Joana
Santos, Andrea
Nunes, Alexandra
Borges, Vítor
Silva, Catarina
Vieira, Luís
Mendes, Aristides L.
Serrano, Mónica
Henriques, Adriano O.
Gomes, João Paulo
Oleastro, Mónica
author_role author
author2 Santos, Andrea
Nunes, Alexandra
Borges, Vítor
Silva, Catarina
Vieira, Luís
Mendes, Aristides L.
Serrano, Mónica
Henriques, Adriano O.
Gomes, João Paulo
Oleastro, Mónica
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Isidro, Joana
Santos, Andrea
Nunes, Alexandra
Borges, Vítor
Silva, Catarina
Vieira, Luís
Mendes, Aristides L.
Serrano, Mónica
Henriques, Adriano O.
Gomes, João Paulo
Oleastro, Mónica
dc.subject.por.fl_str_mv Amino Acid Sequence
Anti-Bacterial Agents
Clostridium difficile
Enterocolitis, Pseudomembranous
Genome, Bacterial
Humans
Imipenem
Microbial Sensitivity Tests
Mutation
Phylogeny
Portugal
Whole Genome Sequencing
Drug Resistance, Bacterial
Ribotyping
Infecções Gastrointestinais
topic Amino Acid Sequence
Anti-Bacterial Agents
Clostridium difficile
Enterocolitis, Pseudomembranous
Genome, Bacterial
Humans
Imipenem
Microbial Sensitivity Tests
Mutation
Phylogeny
Portugal
Whole Genome Sequencing
Drug Resistance, Bacterial
Ribotyping
Infecções Gastrointestinais
description We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
publishDate 2018
dc.date.none.fl_str_mv 2018-04
2018-04-01T00:00:00Z
2019-03-20T18:11:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/6256
url http://hdl.handle.net/10400.18/6256
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Emerg Infect Dis. 2018 Apr;24(4):741-745. doi: 10.3201/eid2404.170095
1080-6040
10.3201/eid2404.170095
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Centers for Disease Control and Prevention
publisher.none.fl_str_mv Centers for Disease Control and Prevention
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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