Relationship Between Bioimpedance-Determined Body Composition and Peritoneal Transport in Peritoneal Dialysis
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/2909 |
Resumo: | PURPOSE: In peritoneal dialysis (PD) patients, body fluid homeostasis is dependent on peritoneal elimination of water and solutes. Patients with less favorable peritoneal transport parameters should be more overhydrated. Despite this, the association between faster transport and overhydration (OH) is weak, and the factors that influence hydration status are still poorly characterized. Modified peritoneal equilibration tests (PET) offer us new parameters that might correlate better with hydration status, like free water transport (FWT). The aim of this study was thus to establish the relationships between new peritoneal transport parameters and body composition parameters estimated by bioimpedance spectroscopy (BIS). METHODS: Prospective observational study on incident PD patients with a baseline and 1-year follow-up evaluation. RESULTS: 61 patients were included in the baseline evaluation, 19 of whom had a 1-year follow-up evaluation; 67.2% were fluid overloaded. There was a negative correlation between D/P creatinine and FWT (r = -0.598, p = 0.000). The fraction of FWT was negatively correlated with OH (r = -0.302, p = 0.018). Peritoneal protein losses (PPL) were also correlated with OH (r = 0.287, p = 0.028). There were no significant differences in OH according to small-solute transport status or fluid output parameters. After 1 year, we observed a significant worsening of renal function and an improvement in 24-hour ultrafiltration (UF) and hydration status, but we detected no differences in peritoneal transport of water or solutes that could explain these changes. CONCLUSIONS: There is a poor relationship between kidney/peritoneal function parameters and body composition parameters. The fraction of FWT and PPL may be underestimated markers of peritoneal health and of its contribution to the hydration status. |
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Relationship Between Bioimpedance-Determined Body Composition and Peritoneal Transport in Peritoneal DialysisAdultAgedBiological TransportBody CompositionElectric ImpedanceFemaleHumansMaleMiddle AgedPeritoneumProspective StudiesWater-Electrolyte ImbalancePeritoneal DialysisHCC NEFPURPOSE: In peritoneal dialysis (PD) patients, body fluid homeostasis is dependent on peritoneal elimination of water and solutes. Patients with less favorable peritoneal transport parameters should be more overhydrated. Despite this, the association between faster transport and overhydration (OH) is weak, and the factors that influence hydration status are still poorly characterized. Modified peritoneal equilibration tests (PET) offer us new parameters that might correlate better with hydration status, like free water transport (FWT). The aim of this study was thus to establish the relationships between new peritoneal transport parameters and body composition parameters estimated by bioimpedance spectroscopy (BIS). METHODS: Prospective observational study on incident PD patients with a baseline and 1-year follow-up evaluation. RESULTS: 61 patients were included in the baseline evaluation, 19 of whom had a 1-year follow-up evaluation; 67.2% were fluid overloaded. There was a negative correlation between D/P creatinine and FWT (r = -0.598, p = 0.000). The fraction of FWT was negatively correlated with OH (r = -0.302, p = 0.018). Peritoneal protein losses (PPL) were also correlated with OH (r = 0.287, p = 0.028). There were no significant differences in OH according to small-solute transport status or fluid output parameters. After 1 year, we observed a significant worsening of renal function and an improvement in 24-hour ultrafiltration (UF) and hydration status, but we detected no differences in peritoneal transport of water or solutes that could explain these changes. CONCLUSIONS: There is a poor relationship between kidney/peritoneal function parameters and body composition parameters. The fraction of FWT and PPL may be underestimated markers of peritoneal health and of its contribution to the hydration status.WichtigRepositório do Centro Hospitalar Universitário de Lisboa Central, EPECosta, BDel Peso, GBajo, MACarreño, GFerreira, MFerreira, CSelgas, R2018-02-16T15:47:26Z2017-05-292017-05-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2909engInt J Artif Organs. 2017 May 29;40(5):212-21810.5301/ijao.5000584info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:40:16Zoai:repositorio.chlc.min-saude.pt:10400.17/2909Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:14.144567Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Relationship Between Bioimpedance-Determined Body Composition and Peritoneal Transport in Peritoneal Dialysis |
title |
Relationship Between Bioimpedance-Determined Body Composition and Peritoneal Transport in Peritoneal Dialysis |
spellingShingle |
Relationship Between Bioimpedance-Determined Body Composition and Peritoneal Transport in Peritoneal Dialysis Costa, B Adult Aged Biological Transport Body Composition Electric Impedance Female Humans Male Middle Aged Peritoneum Prospective Studies Water-Electrolyte Imbalance Peritoneal Dialysis HCC NEF |
title_short |
Relationship Between Bioimpedance-Determined Body Composition and Peritoneal Transport in Peritoneal Dialysis |
title_full |
Relationship Between Bioimpedance-Determined Body Composition and Peritoneal Transport in Peritoneal Dialysis |
title_fullStr |
Relationship Between Bioimpedance-Determined Body Composition and Peritoneal Transport in Peritoneal Dialysis |
title_full_unstemmed |
Relationship Between Bioimpedance-Determined Body Composition and Peritoneal Transport in Peritoneal Dialysis |
title_sort |
Relationship Between Bioimpedance-Determined Body Composition and Peritoneal Transport in Peritoneal Dialysis |
author |
Costa, B |
author_facet |
Costa, B Del Peso, G Bajo, MA Carreño, G Ferreira, M Ferreira, C Selgas, R |
author_role |
author |
author2 |
Del Peso, G Bajo, MA Carreño, G Ferreira, M Ferreira, C Selgas, R |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Costa, B Del Peso, G Bajo, MA Carreño, G Ferreira, M Ferreira, C Selgas, R |
dc.subject.por.fl_str_mv |
Adult Aged Biological Transport Body Composition Electric Impedance Female Humans Male Middle Aged Peritoneum Prospective Studies Water-Electrolyte Imbalance Peritoneal Dialysis HCC NEF |
topic |
Adult Aged Biological Transport Body Composition Electric Impedance Female Humans Male Middle Aged Peritoneum Prospective Studies Water-Electrolyte Imbalance Peritoneal Dialysis HCC NEF |
description |
PURPOSE: In peritoneal dialysis (PD) patients, body fluid homeostasis is dependent on peritoneal elimination of water and solutes. Patients with less favorable peritoneal transport parameters should be more overhydrated. Despite this, the association between faster transport and overhydration (OH) is weak, and the factors that influence hydration status are still poorly characterized. Modified peritoneal equilibration tests (PET) offer us new parameters that might correlate better with hydration status, like free water transport (FWT). The aim of this study was thus to establish the relationships between new peritoneal transport parameters and body composition parameters estimated by bioimpedance spectroscopy (BIS). METHODS: Prospective observational study on incident PD patients with a baseline and 1-year follow-up evaluation. RESULTS: 61 patients were included in the baseline evaluation, 19 of whom had a 1-year follow-up evaluation; 67.2% were fluid overloaded. There was a negative correlation between D/P creatinine and FWT (r = -0.598, p = 0.000). The fraction of FWT was negatively correlated with OH (r = -0.302, p = 0.018). Peritoneal protein losses (PPL) were also correlated with OH (r = 0.287, p = 0.028). There were no significant differences in OH according to small-solute transport status or fluid output parameters. After 1 year, we observed a significant worsening of renal function and an improvement in 24-hour ultrafiltration (UF) and hydration status, but we detected no differences in peritoneal transport of water or solutes that could explain these changes. CONCLUSIONS: There is a poor relationship between kidney/peritoneal function parameters and body composition parameters. The fraction of FWT and PPL may be underestimated markers of peritoneal health and of its contribution to the hydration status. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-05-29 2017-05-29T00:00:00Z 2018-02-16T15:47:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/2909 |
url |
http://hdl.handle.net/10400.17/2909 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Int J Artif Organs. 2017 May 29;40(5):212-218 10.5301/ijao.5000584 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wichtig |
publisher.none.fl_str_mv |
Wichtig |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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