The effect of flaxseed in breast cancer : a literature review

Detalhes bibliográficos
Autor(a) principal: Calado, Ana
Data de Publicação: 2018
Outros Autores: Neves, Pedro Miguel, Santos, Teresa, Ravasco, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/32040
Resumo: Copyright © 2018 Calado, Neves, Santos and Ravasco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling The effect of flaxseed in breast cancer : a literature reviewBreast cancerFlaxseedLignanNutritionOmega-3Copyright © 2018 Calado, Neves, Santos and Ravasco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Breast cancer is one of the most common cancers and the second most responsible for cancer mortality worldwide. In 2014, in Portugal approximately 27,200 people died of cancer, of which 1,791 were women with breast cancer. Flaxseed has been one of the most studied foods, regarding possible relations to breast cancer, though mainly in experimental studies in animals, yet in few clinical trials. It is rich in omega-3 fatty acids, α-linolenic acid, lignan, and fibers. One of the main components of flaxseed is the lignans, of which 95% are made of the predominant secoisolariciresinol diglucoside (SDG). SDG is converted into enterolactone and enterodiol, both with antiestrogen activity and structurally similar to estrogen; they can bind to cell receptors, decreasing cell growth. Some studies have shown that the intake of omega-3 fatty acids is related to the reduction of breast cancer risk. In animal studies, α-linolenic acids have been shown to be able to suppress growth, size, and proliferation of cancer cells and also to promote breast cancer cell death. Other animal studies found that the intake of flaxseed combined with tamoxifen can reduce tumor size to a greater extent than taking tamoxifen alone. Additionally, some clinical trials showed that flaxseed can have an important role in decreasing breast cancer risk, mainly in postmenopausal women. Further studies are needed, specifically clinical trials that may demonstrate the potential benefits of flaxseed in breast cancer.FrontiersRepositório da Universidade de LisboaCalado, AnaNeves, Pedro MiguelSantos, TeresaRavasco, Paula2018-02-28T10:57:42Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/32040engFrontiers in Nutrition, February 2018, Volume 5, Article 42296-861X10.3389/fnut.2018.00004info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:25:56Zoai:repositorio.ul.pt:10451/32040Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:47:20.461933Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The effect of flaxseed in breast cancer : a literature review
title The effect of flaxseed in breast cancer : a literature review
spellingShingle The effect of flaxseed in breast cancer : a literature review
Calado, Ana
Breast cancer
Flaxseed
Lignan
Nutrition
Omega-3
title_short The effect of flaxseed in breast cancer : a literature review
title_full The effect of flaxseed in breast cancer : a literature review
title_fullStr The effect of flaxseed in breast cancer : a literature review
title_full_unstemmed The effect of flaxseed in breast cancer : a literature review
title_sort The effect of flaxseed in breast cancer : a literature review
author Calado, Ana
author_facet Calado, Ana
Neves, Pedro Miguel
Santos, Teresa
Ravasco, Paula
author_role author
author2 Neves, Pedro Miguel
Santos, Teresa
Ravasco, Paula
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Calado, Ana
Neves, Pedro Miguel
Santos, Teresa
Ravasco, Paula
dc.subject.por.fl_str_mv Breast cancer
Flaxseed
Lignan
Nutrition
Omega-3
topic Breast cancer
Flaxseed
Lignan
Nutrition
Omega-3
description Copyright © 2018 Calado, Neves, Santos and Ravasco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2018
dc.date.none.fl_str_mv 2018-02-28T10:57:42Z
2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/32040
url http://hdl.handle.net/10451/32040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Frontiers in Nutrition, February 2018, Volume 5, Article 4
2296-861X
10.3389/fnut.2018.00004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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