Regulation of Blood Vessel Growth
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Tipo de documento: | Dissertação |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10316/28032 |
Resumo: | Dissertação de Mestrado Integrado em Engenharia Biomédica apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra. |
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7160 |
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Regulation of Blood Vessel GrowthangiogenesisVEGFhybrid modellingphase field modelelasticitymechanical interactionsproliferationDissertação de Mestrado Integrado em Engenharia Biomédica apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra.Angiogenesis is a complex process where biological signals, such as the activation of signalling pathways by the binding of VEGF to its receptors at the cell membrane, are converted into mechanical forces originating cell movement. The endothelial cells then re-organize spatially into tubular structures that are able to support the flow of blood and that respond to blood pressure and shear stress by changing their number, shape and size. Therefore, a mathematical description of sprouting angiogenesis has to consider biological signals as well as relevant physical processes. In this thesis, we model sprouting events in angiogenesis using a continuum model that takes into account the tissue elasticity and the forces exerted by the cells in the sprout. We demonstrate that the endothelial cell proliferation has to be regulated by the local mechanical stress for a well-formed vascular sprout. The force exerted at the tip cell induces an increase in the stress, which determines the locations with higher endothelial cell proliferation. The model also permits a new look into how anastomosis events are controlled by the local tissue displacements. Our results highlight the ability of mathematical models to suggest relevant hypotheses with respect to the role of forces in sprouting, hence underlining the necessary collaboration between modelling and molecular biology techniques to improve our knowledge of the angiogenesis process.2014-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10316/28032http://hdl.handle.net/10316/28032TID:201535351engOliveira, Patrícia dos Santos/Regulation of Blood Vessel GrowthOliveira, Patricia dos Santosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-01-28T11:39:21Zoai:estudogeral.uc.pt:10316/28032Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:00:33.234189Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Regulation of Blood Vessel Growth |
| title |
Regulation of Blood Vessel Growth |
| spellingShingle |
Regulation of Blood Vessel Growth Oliveira, Patricia dos Santos angiogenesis VEGF hybrid modelling phase field model elasticity mechanical interactions proliferation |
| title_short |
Regulation of Blood Vessel Growth |
| title_full |
Regulation of Blood Vessel Growth |
| title_fullStr |
Regulation of Blood Vessel Growth |
| title_full_unstemmed |
Regulation of Blood Vessel Growth |
| title_sort |
Regulation of Blood Vessel Growth |
| author |
Oliveira, Patricia dos Santos |
| author_facet |
Oliveira, Patricia dos Santos |
| author_role |
author |
| dc.contributor.author.fl_str_mv |
Oliveira, Patricia dos Santos |
| dc.subject.por.fl_str_mv |
angiogenesis VEGF hybrid modelling phase field model elasticity mechanical interactions proliferation |
| topic |
angiogenesis VEGF hybrid modelling phase field model elasticity mechanical interactions proliferation |
| description |
Dissertação de Mestrado Integrado em Engenharia Biomédica apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014-09 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| format |
masterThesis |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/28032 http://hdl.handle.net/10316/28032 TID:201535351 |
| url |
http://hdl.handle.net/10316/28032 |
| identifier_str_mv |
TID:201535351 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Oliveira, Patrícia dos Santos/Regulation of Blood Vessel Growth |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133896200159232 |