FACTORS ASSOCIATED WITH TARGET ORGAN DAMAGE HOSPITALIZATION IN PATIENTS FOLLOWED IN A SYSTEMIC ARTERIAL HYPERTENSION CLINIC: A CASE-CONTROL STUDY

• Autor(a) principal: Bilreiro, Mariana
• Data de Publicação: 2023
• Outros Autores: Marote Correia, Luís, Silva, Ana Sofia, Brasão, Maria da Luz
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://doi.org/10.58043/rphrc.54
• topic: pressão arterial; hipertensão; enfarte do miocárdio; acidente vascular cerebral; hospitalização; blood pressure; hypertension; myocardial infarction; stroke; hospitalization

To identify factors associated with hospitalization for target organ damage (HTOD) in patients followed in a systemic arterial hypertension (SAH) specialized clinic, we designed a retrospective case-control study. We analyzed the automatic blood pressure (BP) measurements profile performed in the office. We extracted data in terms of causes of SAH, vascular risk factors and started antihypertensive therapy. We identified 42 cases that required at least one HTOD between 2010 and 2020. The main reasons for HTOD were cerebral infarction (19 cases; 45.2%) and acute myocardial infarction (14 cases; 35.7%). The mean age of occurrence of HTOD was 63.8 (standard deviation [SD] 12.9) years, being 73.0 (SD 39.0) years for cerebral infarction and 65.0 (SD 51.0) years for acute myocardial infarction. Three patients (7.1%) suffered a second HTOD. We selected 84 controls without HTOD followed at the same clinic matched with cases by sex and year of birth. The groups were distinct in terms of mean systolic BP (with HTOD 158.6 versus without HTOD 145.9 mmHg; p < 0.001), SD of systolic BP (18.4 versus 14.5 mmHg; p = 0.002), coefficient of variability (CV) of systolic BP (0.12 versus 0.10; p = 0.033), mean of diastolic BP (83.5 versus 76.7 mmHg; p = 0.002) and SD of diastolic BP (10.9 versus 8.8 mmHg; p = 0.003) but not the CV of diastolic BP (0.13 versus 0.12; p = 0.113). In the multivariate analysis, associated with HTOD were: systolic BP ≥ 160 mmHg in 10% or more of the measurements (adjusted odds ratio [AOR] 3.0; p = 0.034), diastolic BP ≥ 100 mmHg in 10% or more of the measurements (AOR 3.8; p = 0.006), presence of 2 or more comorbidities (between diabetes mellitus, current or previous smoking, dyslipidemia or atrial fibrillation) (AOR 3.1; p = 0.016) and chronic kidney disease (AOR 2.7; p = 0.027).