Superiority of 18F-FNa PET/CT for Detecting Bone Metastases in Comparison with Other Diagnostic Imaging Modalities
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818 |
Resumo: | Introduction: The 18F-NaF positron emission tomography/computed tomography is being considered as an excellent imaging modalityfor bone metastases detection. This ability was compared with other imaging techniques.Material and Methods: We retrospectively evaluated 114 patients who underwent 18F-NaF positron emission tomography/ computed tomography. Of these, 49 patients also had bone scintigraphy, 61 18F-FDG positron emission tomography/computed tomography and 10 18F-FCH positron emission tomography/computed tomography. We identified the technique that detected the largest number of bone metastases. For the detection of skeletal metastases with the 18F-NaF positron emission tomography/computed tomography study,the contribution of the positron emission tomography component was compared with the contribution of the computed tomography component. Cases in which 18F-NaF positron emission tomography/computed tomography and bone scintigraphy required further additional tests for diagnosis clarification were registered.Results: The 18F-NaF positron emission tomography/computed tomography was superior to bone scintigraphy in 49% of the patients(p < 0.001); it was superior to 18F-FDG positron emission tomography/computed tomography in 59% of the patients (p < 0.001) and it was superior to 18F-FCH positron emission tomography/computed tomography in 40% of the patients (p < 0.001). None of the compared imaging techniques were superior to 18F-NaF positron emission tomography/computed tomography. The positron emission tomography component was superior to computed tomography in 35% of the cases (p < 0.001). Further investigation was suggested in only 3.5% of patients who underwent 18F-NaF positron emission tomography/computed tomography (45% for bone scintigraphy) (p < 0.001).Discussion: As with other authors, our experience also confirms that 18F-NaF positron emission tomography/computed tomography is an excellent imaging modality for the detection of bone metastases, detecting lesions in more patients and more lesions per patient.Conclusion: The 18F-NaF positron emission tomography/computed tomography showed a superior ability for the detection of bone metastases when compared with bone scintigraphy, 18F-FDG positron emission tomography/computed tomography and 18F-FCH positron emission tomography/computed tomography. |
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Superiority of 18F-FNa PET/CT for Detecting Bone Metastases in Comparison with Other Diagnostic Imaging ModalitiesSuperioridade da PET/CT com FNa-F18 na Deteção de Metástases Ósseas quando Comparada com Outros Métodos de Diagnóstico por ImagemBone Neoplasms/diagnostic imagingBone Neoplasms/secondary Fluorodeoxyglucose F18Positron-Emission TomographyRadionuclide ImagingCintigrafiaNeoplasias Ósseas/diagnóstico por imagemNeoplasias Ósseas/secundárioTomografia por Emissão de PositrõesIntroduction: The 18F-NaF positron emission tomography/computed tomography is being considered as an excellent imaging modalityfor bone metastases detection. This ability was compared with other imaging techniques.Material and Methods: We retrospectively evaluated 114 patients who underwent 18F-NaF positron emission tomography/ computed tomography. Of these, 49 patients also had bone scintigraphy, 61 18F-FDG positron emission tomography/computed tomography and 10 18F-FCH positron emission tomography/computed tomography. We identified the technique that detected the largest number of bone metastases. For the detection of skeletal metastases with the 18F-NaF positron emission tomography/computed tomography study,the contribution of the positron emission tomography component was compared with the contribution of the computed tomography component. Cases in which 18F-NaF positron emission tomography/computed tomography and bone scintigraphy required further additional tests for diagnosis clarification were registered.Results: The 18F-NaF positron emission tomography/computed tomography was superior to bone scintigraphy in 49% of the patients(p < 0.001); it was superior to 18F-FDG positron emission tomography/computed tomography in 59% of the patients (p < 0.001) and it was superior to 18F-FCH positron emission tomography/computed tomography in 40% of the patients (p < 0.001). None of the compared imaging techniques were superior to 18F-NaF positron emission tomography/computed tomography. The positron emission tomography component was superior to computed tomography in 35% of the cases (p < 0.001). Further investigation was suggested in only 3.5% of patients who underwent 18F-NaF positron emission tomography/computed tomography (45% for bone scintigraphy) (p < 0.001).Discussion: As with other authors, our experience also confirms that 18F-NaF positron emission tomography/computed tomography is an excellent imaging modality for the detection of bone metastases, detecting lesions in more patients and more lesions per patient.Conclusion: The 18F-NaF positron emission tomography/computed tomography showed a superior ability for the detection of bone metastases when compared with bone scintigraphy, 18F-FDG positron emission tomography/computed tomography and 18F-FCH positron emission tomography/computed tomography.Introdução: A tomografia por emissão de positrões/tomografia computorizada - FNa-F18 vem sendo considerada como uma modalidade imagiológica com vantagens na pesquisa de metastização óssea. Comparámos a sua capacidade para deteção de metástases ósseas com a de outras técnicas imagiológicas.Material e Métodos: Avaliámos retrospetivamente 114 doentes que realizaram tomografia por emissão de positrões/tomografia computorizada - FNa-F18. Destes, 49 realizaram também cintigrafia óssea, 61 tomografia por emissão de positrões/tomografia computorizada - FDG-F18 e 10 tomografia por emissão de positrões/tomografia computorizada - FCH-F18. Identificámos a técnica que detetou um maior número de metástases ósseas. Comparámos ainda a tomografia por emissão de positrões com a componente tomografia computorizada da tomografia por emissão de positrões/tomografia computorizada - FNa-F18. Registámos as situações nas quais a tomografia por emissão de positrões/tomografia computorizada FNa-F18 e a cintigrafia óssea necessitaram de exames adicionais para esclarecimento complementar.Resultados: A tomografia por emissão de positrões/tomografia computorizada - FNa-F18 foi superior à cintigrafia óssea em 49% dos doentes (p < 0,001); foi superior à tomografia por emissão de positrões/tomografia computorizada - FDG-F18 em 59% dos doentes (p < 0,001) e foi superior à tomografia por emissão de positrões/tomografia computorizada - FCH-F18 em 40% dos doentes (p < 0,001). Nenhuma das técnicas imagiológicas avaliadas lhe foi superior. Na tomografia por emissão de positrões/tomografia computorizada -FNa-F18 a componente tomografia por emissão de positrões foi superior à tomografia computorizada em 35% dos casos (p < 0,001). Foi sugerida investigação complementar em apenas 3,5% dos doentes que realizaram tomografia por emissão de positrões/ tomografia computorizada - FNa-F18 (45% para a cintigrafia óssea) (p < 0,001).Discussão: Em conformidade com o referido por outros autores, a nossa experiência confirma que a tomografia por emissão de positrões/tomografia computorizada - FNa-F18 tem excelente desempenho na deteção de metástases ósseas, sendo capaz de identificar lesões em mais doentes, e em maior número, quando comparada com outras técnicas imagiológicas.Conclusão: A tomografia por emissão de positrões/tomografia computorizada - FNa-F18 revelou superioridade na deteção de metástases ósseas comparativamente à cintigrafia óssea, à tomografia por emissão de positrões/tomografia computorizada - FDG-F18 e à tomografia por emissão de positrões/tomografia computorizada - FCH- F18.Ordem dos Médicos2017-01-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffapplication/pdfapplication/mswordapplication/mswordimage/jpeghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818oai:ojs.www.actamedicaportuguesa.com:article/7818Acta Médica Portuguesa; Vol. 30 No. 1 (2017): January; 53-60Acta Médica Portuguesa; Vol. 30 N.º 1 (2017): Janeiro; 53-601646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/4892https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/5137https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8470https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8471https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8472https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8473https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8474https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8475https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8476https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8516https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8637https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8731https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8772Direitos de Autor (c) 2017 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessLapa, PaulaSaraiva, TiagoSilva, RodolfoMarques, MargaridaCosta, GracindaLima, João Pedroso2022-12-20T11:05:20Zoai:ojs.www.actamedicaportuguesa.com:article/7818Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:30.266942Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Superiority of 18F-FNa PET/CT for Detecting Bone Metastases in Comparison with Other Diagnostic Imaging Modalities Superioridade da PET/CT com FNa-F18 na Deteção de Metástases Ósseas quando Comparada com Outros Métodos de Diagnóstico por Imagem |
title |
Superiority of 18F-FNa PET/CT for Detecting Bone Metastases in Comparison with Other Diagnostic Imaging Modalities |
spellingShingle |
Superiority of 18F-FNa PET/CT for Detecting Bone Metastases in Comparison with Other Diagnostic Imaging Modalities Lapa, Paula Bone Neoplasms/diagnostic imaging Bone Neoplasms/secondary Fluorodeoxyglucose F18 Positron-Emission Tomography Radionuclide Imaging Cintigrafia Neoplasias Ósseas/diagnóstico por imagem Neoplasias Ósseas/secundário Tomografia por Emissão de Positrões |
title_short |
Superiority of 18F-FNa PET/CT for Detecting Bone Metastases in Comparison with Other Diagnostic Imaging Modalities |
title_full |
Superiority of 18F-FNa PET/CT for Detecting Bone Metastases in Comparison with Other Diagnostic Imaging Modalities |
title_fullStr |
Superiority of 18F-FNa PET/CT for Detecting Bone Metastases in Comparison with Other Diagnostic Imaging Modalities |
title_full_unstemmed |
Superiority of 18F-FNa PET/CT for Detecting Bone Metastases in Comparison with Other Diagnostic Imaging Modalities |
title_sort |
Superiority of 18F-FNa PET/CT for Detecting Bone Metastases in Comparison with Other Diagnostic Imaging Modalities |
author |
Lapa, Paula |
author_facet |
Lapa, Paula Saraiva, Tiago Silva, Rodolfo Marques, Margarida Costa, Gracinda Lima, João Pedroso |
author_role |
author |
author2 |
Saraiva, Tiago Silva, Rodolfo Marques, Margarida Costa, Gracinda Lima, João Pedroso |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Lapa, Paula Saraiva, Tiago Silva, Rodolfo Marques, Margarida Costa, Gracinda Lima, João Pedroso |
dc.subject.por.fl_str_mv |
Bone Neoplasms/diagnostic imaging Bone Neoplasms/secondary Fluorodeoxyglucose F18 Positron-Emission Tomography Radionuclide Imaging Cintigrafia Neoplasias Ósseas/diagnóstico por imagem Neoplasias Ósseas/secundário Tomografia por Emissão de Positrões |
topic |
Bone Neoplasms/diagnostic imaging Bone Neoplasms/secondary Fluorodeoxyglucose F18 Positron-Emission Tomography Radionuclide Imaging Cintigrafia Neoplasias Ósseas/diagnóstico por imagem Neoplasias Ósseas/secundário Tomografia por Emissão de Positrões |
description |
Introduction: The 18F-NaF positron emission tomography/computed tomography is being considered as an excellent imaging modalityfor bone metastases detection. This ability was compared with other imaging techniques.Material and Methods: We retrospectively evaluated 114 patients who underwent 18F-NaF positron emission tomography/ computed tomography. Of these, 49 patients also had bone scintigraphy, 61 18F-FDG positron emission tomography/computed tomography and 10 18F-FCH positron emission tomography/computed tomography. We identified the technique that detected the largest number of bone metastases. For the detection of skeletal metastases with the 18F-NaF positron emission tomography/computed tomography study,the contribution of the positron emission tomography component was compared with the contribution of the computed tomography component. Cases in which 18F-NaF positron emission tomography/computed tomography and bone scintigraphy required further additional tests for diagnosis clarification were registered.Results: The 18F-NaF positron emission tomography/computed tomography was superior to bone scintigraphy in 49% of the patients(p < 0.001); it was superior to 18F-FDG positron emission tomography/computed tomography in 59% of the patients (p < 0.001) and it was superior to 18F-FCH positron emission tomography/computed tomography in 40% of the patients (p < 0.001). None of the compared imaging techniques were superior to 18F-NaF positron emission tomography/computed tomography. The positron emission tomography component was superior to computed tomography in 35% of the cases (p < 0.001). Further investigation was suggested in only 3.5% of patients who underwent 18F-NaF positron emission tomography/computed tomography (45% for bone scintigraphy) (p < 0.001).Discussion: As with other authors, our experience also confirms that 18F-NaF positron emission tomography/computed tomography is an excellent imaging modality for the detection of bone metastases, detecting lesions in more patients and more lesions per patient.Conclusion: The 18F-NaF positron emission tomography/computed tomography showed a superior ability for the detection of bone metastases when compared with bone scintigraphy, 18F-FDG positron emission tomography/computed tomography and 18F-FCH positron emission tomography/computed tomography. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818 oai:ojs.www.actamedicaportuguesa.com:article/7818 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/7818 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/4892 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/5137 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8470 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8471 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8472 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8473 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8474 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8475 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8476 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8516 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8637 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8731 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7818/8772 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2017 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2017 Acta Médica Portuguesa |
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openAccess |
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Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 30 No. 1 (2017): January; 53-60 Acta Médica Portuguesa; Vol. 30 N.º 1 (2017): Janeiro; 53-60 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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