Elementary and efficient catalyst process for the Knoevenagel condensation of araldehydes with arylmethylidene malononitrile
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/8014 |
Resumo: | A comparative study of the Knoevenagel condensation of an aromatic aldehyde with an active methylene compound (e.g., malononitrile or ethyl cyanoacetate), using solvent free grindstone conditions and microwave irradiation is reported. Our solvent free approaches led these reactions to proceed faster, more cleanly and in higher yields. Moreover, they also allowed the use of nitrobenzaldehydes, which failed to yield the desired products under traditional and water based approaches. Thus, an efficient procedure for the Knoevenagel condensation of aryl and heteroaromatic aldehydes with malononitrile. using the complex [CdNa2(mu-L-2)](n)center dot 6.34H(2)O or commercial CdO as catalyst under solvent-free and very mild conditions has been developed. (C) 2017 Elsevier B.V. All rights reserved. |
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Elementary and efficient catalyst process for the Knoevenagel condensation of araldehydes with arylmethylidene malononitrileKnoevenagel condensationGrindstone techniqueMicrowaveMalononitrileSolvent-free reactionA comparative study of the Knoevenagel condensation of an aromatic aldehyde with an active methylene compound (e.g., malononitrile or ethyl cyanoacetate), using solvent free grindstone conditions and microwave irradiation is reported. Our solvent free approaches led these reactions to proceed faster, more cleanly and in higher yields. Moreover, they also allowed the use of nitrobenzaldehydes, which failed to yield the desired products under traditional and water based approaches. Thus, an efficient procedure for the Knoevenagel condensation of aryl and heteroaromatic aldehydes with malononitrile. using the complex [CdNa2(mu-L-2)](n)center dot 6.34H(2)O or commercial CdO as catalyst under solvent-free and very mild conditions has been developed. (C) 2017 Elsevier B.V. All rights reserved.ElsevierRCIPLJlassi, RajaDa Costa Ribeiro, Ana PaulaTiago, GonçaloWang, JiaweiKrawczyk, Marta S.Martins, LuisaNaili, HoucinePombeiro, ArmandoRekik, Walid2018-02-01T12:33:42Z2018-02-242018-02-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/8014engJLASSI, Raja; [et al] – Elementary and efficient catalyst process for the Knoevenagel condensation of araldehydes with arylmethylidene malononitrile. Inorganica Chimica Acta. ISSN 0020-1693. Vol. 471 (2018), pp. 76-810020-169310.1016/j.ica.2017.10.028metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:54:51Zoai:repositorio.ipl.pt:10400.21/8014Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:16:51.438453Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Elementary and efficient catalyst process for the Knoevenagel condensation of araldehydes with arylmethylidene malononitrile |
title |
Elementary and efficient catalyst process for the Knoevenagel condensation of araldehydes with arylmethylidene malononitrile |
spellingShingle |
Elementary and efficient catalyst process for the Knoevenagel condensation of araldehydes with arylmethylidene malononitrile Jlassi, Raja Knoevenagel condensation Grindstone technique Microwave Malononitrile Solvent-free reaction |
title_short |
Elementary and efficient catalyst process for the Knoevenagel condensation of araldehydes with arylmethylidene malononitrile |
title_full |
Elementary and efficient catalyst process for the Knoevenagel condensation of araldehydes with arylmethylidene malononitrile |
title_fullStr |
Elementary and efficient catalyst process for the Knoevenagel condensation of araldehydes with arylmethylidene malononitrile |
title_full_unstemmed |
Elementary and efficient catalyst process for the Knoevenagel condensation of araldehydes with arylmethylidene malononitrile |
title_sort |
Elementary and efficient catalyst process for the Knoevenagel condensation of araldehydes with arylmethylidene malononitrile |
author |
Jlassi, Raja |
author_facet |
Jlassi, Raja Da Costa Ribeiro, Ana Paula Tiago, Gonçalo Wang, Jiawei Krawczyk, Marta S. Martins, Luisa Naili, Houcine Pombeiro, Armando Rekik, Walid |
author_role |
author |
author2 |
Da Costa Ribeiro, Ana Paula Tiago, Gonçalo Wang, Jiawei Krawczyk, Marta S. Martins, Luisa Naili, Houcine Pombeiro, Armando Rekik, Walid |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Jlassi, Raja Da Costa Ribeiro, Ana Paula Tiago, Gonçalo Wang, Jiawei Krawczyk, Marta S. Martins, Luisa Naili, Houcine Pombeiro, Armando Rekik, Walid |
dc.subject.por.fl_str_mv |
Knoevenagel condensation Grindstone technique Microwave Malononitrile Solvent-free reaction |
topic |
Knoevenagel condensation Grindstone technique Microwave Malononitrile Solvent-free reaction |
description |
A comparative study of the Knoevenagel condensation of an aromatic aldehyde with an active methylene compound (e.g., malononitrile or ethyl cyanoacetate), using solvent free grindstone conditions and microwave irradiation is reported. Our solvent free approaches led these reactions to proceed faster, more cleanly and in higher yields. Moreover, they also allowed the use of nitrobenzaldehydes, which failed to yield the desired products under traditional and water based approaches. Thus, an efficient procedure for the Knoevenagel condensation of aryl and heteroaromatic aldehydes with malononitrile. using the complex [CdNa2(mu-L-2)](n)center dot 6.34H(2)O or commercial CdO as catalyst under solvent-free and very mild conditions has been developed. (C) 2017 Elsevier B.V. All rights reserved. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-02-01T12:33:42Z 2018-02-24 2018-02-24T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/8014 |
url |
http://hdl.handle.net/10400.21/8014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
JLASSI, Raja; [et al] – Elementary and efficient catalyst process for the Knoevenagel condensation of araldehydes with arylmethylidene malononitrile. Inorganica Chimica Acta. ISSN 0020-1693. Vol. 471 (2018), pp. 76-81 0020-1693 10.1016/j.ica.2017.10.028 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133429546090496 |