Retinopathy of prematurity: a review of pathophysiology and signaling pathways

Detalhes bibliográficos
Autor(a) principal: Fevereiro-Martins, Mariza
Data de Publicação: 2023
Outros Autores: Marques-Neves, Carlos, Guimarães, Hercília, Bicho, Manuel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/56306
Resumo: © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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spelling Retinopathy of prematurity: a review of pathophysiology and signaling pathwaysRetinopathy of prematurityNeovascularizationOxidative stressPathophysiologyPreterm infant© 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading cause of visual impairment and childhood blindness worldwide. The disease is characterized by an early stage of retinal microvascular degeneration, followed by neovascularization that can lead to subsequent retinal detachment and permanent visual loss. Several factors play a key role during the different pathological stages of the disease. Oxidative and nitrosative stress and inflammatory processes are important contributors to the early stage of ROP. Nitric oxide synthase and arginase play important roles in ischemia/reperfusion-induced neurovascular degeneration. Destructive neovascularization is driven by mediators of the hypoxia-inducible factor pathway, such as vascular endothelial growth factor and metabolic factors (succinate). The extracellular matrix is involved in hypoxia-induced retinal neovascularization. Vasorepulsive molecules (semaphorin 3A) intervene preventing the revascularization of the avascular zone. This review focuses on current concepts about signaling pathways and their mediators, involved in the pathogenesis of ROP, highlighting new potentially preventive and therapeutic modalities. A better understanding of the intricate molecular mechanisms underlying the pathogenesis of ROP should allow the development of more effective and targeted therapeutic agents to reduce aberrant vasoproliferation and facilitate physiological retinal vascular development.This work is supported by the Laboratório de Genética and the Instituto de Saúde Ambiental (ISAMB) of the Medical Faculty of Lisbon and the Instituto de Investigação Científica Bento da Rocha CabralElsevierRepositório da Universidade de LisboaFevereiro-Martins, MarizaMarques-Neves, CarlosGuimarães, HercíliaBicho, Manuel2023-02-14T15:03:08Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56306engSurv Ophthalmol. 2023 Mar-Apr;68(2):175-2100039-625710.1016/j.survophthal.2022.11.0071879-3304info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:03:47Zoai:repositorio.ul.pt:10451/56306Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:50.754263Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Retinopathy of prematurity: a review of pathophysiology and signaling pathways
title Retinopathy of prematurity: a review of pathophysiology and signaling pathways
spellingShingle Retinopathy of prematurity: a review of pathophysiology and signaling pathways
Fevereiro-Martins, Mariza
Retinopathy of prematurity
Neovascularization
Oxidative stress
Pathophysiology
Preterm infant
title_short Retinopathy of prematurity: a review of pathophysiology and signaling pathways
title_full Retinopathy of prematurity: a review of pathophysiology and signaling pathways
title_fullStr Retinopathy of prematurity: a review of pathophysiology and signaling pathways
title_full_unstemmed Retinopathy of prematurity: a review of pathophysiology and signaling pathways
title_sort Retinopathy of prematurity: a review of pathophysiology and signaling pathways
author Fevereiro-Martins, Mariza
author_facet Fevereiro-Martins, Mariza
Marques-Neves, Carlos
Guimarães, Hercília
Bicho, Manuel
author_role author
author2 Marques-Neves, Carlos
Guimarães, Hercília
Bicho, Manuel
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Fevereiro-Martins, Mariza
Marques-Neves, Carlos
Guimarães, Hercília
Bicho, Manuel
dc.subject.por.fl_str_mv Retinopathy of prematurity
Neovascularization
Oxidative stress
Pathophysiology
Preterm infant
topic Retinopathy of prematurity
Neovascularization
Oxidative stress
Pathophysiology
Preterm infant
description © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
publishDate 2023
dc.date.none.fl_str_mv 2023-02-14T15:03:08Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/56306
url http://hdl.handle.net/10451/56306
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Surv Ophthalmol. 2023 Mar-Apr;68(2):175-210
0039-6257
10.1016/j.survophthal.2022.11.007
1879-3304
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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