Potential causal association between gut microbiome and posttraumatic stress disorder
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/163915 |
Resumo: | Funding Information: We thank the participants and working staff including the Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group, the FinnGen consortium, and the MiBioGen consortium. Publisher Copyright: © 2024, The Author(s). |
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Potential causal association between gut microbiome and posttraumatic stress disorderPsychiatry and Mental healthCellular and Molecular NeuroscienceBiological PsychiatrySDG 3 - Good Health and Well-beingFunding Information: We thank the participants and working staff including the Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group, the FinnGen consortium, and the MiBioGen consortium. Publisher Copyright: © 2024, The Author(s).Background: The causal effects of gut microbiome and the development of posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential causal association using mendelian randomization (MR). Methods: The summary-level statistics for gut microbiome were retrieved from a genome-wide association study (GWAS) of the MiBioGen consortium. As to PTSD, the Freeze 2 datasets were originated from the Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD), and the replicated datasets were obtained from FinnGen consortium. Single nucleotide polymorphisms meeting MR assumptions were selected as instrumental variables. The inverse variance weighting (IVW) method was employed as the main approach, supplemented by sensitivity analyses to evaluate potential pleiotropy and heterogeneity and ensure the robustness of the MR results. We also performed reverse MR analyses to explore PTSD’s causal effects on the relative abundances of specific features of the gut microbiome. Results: In Freeze 2 datasets from PGC-PTSD, eight bacterial traits revealed a potential causal association between gut microbiome and PTSD (IVW, all P < 0.05). In addition, Genus.Dorea and genus.Sellimonas were replicated in FinnGen datasets, in which eight bacterial traits revealed a potential causal association between gut microbiome and the occurrence of PTSD. The heterogeneity and pleiotropy analyses further supported the robustness of the IVW findings, providing additional evidence for their reliability. Conclusion: Our study provides the potential causal impact of gut microbiomes on the development of PTSD, shedding new light on the understanding of the dysfunctional gut-brain axis in this disorder. Our findings present novel evidence and call for investigations to confirm the association between their links, as well as to illuminate the underlying mechanisms.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNHe, QiangWang, WenjingXu, DingkangXiong, YangTao, ChuanyuanYou, ChaoMa, LuMa, JunpengNievergelt, Caroline M.Maihofer, Adam X.Klengel, TorstenAtkinson, Elizabeth G.Chen, Chia YenChoi, Karmel W.Coleman, Jonathan R.I.Dalvie, ShareefaDuncan, Laramie E.Logue, Mark W.Provost, Allison C.Ratanatharathorn, AndrewStein, Murray B.Torres, KatyAiello, Allison E.Almli, Lynn M.Amstadter, Ananda B.Andersen, Søren B.Andreassen, Ole A.Arbisi, Paul A.Ashley-Koch, Allison E.Austin, S. BrynAvdibegovic, EsminaBabić, DraganBækvad-Hansen, MarieBaker, Dewleen G.Beckham, Jean C.Bierut, Laura J.Bisson, Jonathan I.Boks, Marco P.Bolger, Elizabeth A.Børglum, Anders D.Bradley, BekhBrashear, MeganBreen, GeromeBryant, Richard A.Bustamante, Angela C.Bybjerg-Grauholm, JonasCalabrese, Joseph R.Caldas-de-Almeida, José M.Dale, Anders M.Daly, Mark J.Daskalakis, Nikolaos P.Deckert, JürgenDelahanty, Douglas L.Dennis, Michelle F.Disner, Seth G.Domschke, KatharinaDzubur-Kulenovic, AlmaErbes, Christopher R.Evans, AlexandraFarrer, Lindsay A.Feeny, Norah C.Flory, Janine D.Forbes, DavidFranz, Carol E.Galea, SandroGarrett, Melanie E.Gelaye, BizuGelernter, JoelGeuze, ElbertGillespie, CharlesUka, Aferdita GociGordon, Scott D.Guffanti, GuiaHammamieh, RashaHarnal, SupriyaHauser, Michael A.Heath, Andrew C.Hemmings, Sian M.J.Hougaard, David MichaelJakovljevic, MiroJett, MartiJohnson, Eric OttoJones, IanJovanovic, TanjaQin, Xue JunJunglen, Angela G.Karstoft, Karen IngeKaufman, Milissa L.Kessler, Ronald C.Khan, AlaptaginKimbrel, Nathan A.King, Anthony P.Koen, NastassjaKranzler, Henry R.Kremen, William S.Lawford, Bruce R.Lebois, Lauren A.M.Lewis, Catrin E.Linnstaedt, Sarah D.Lori, AdrianaLugonja, BozoLuykx, Jurjen J.Lyons, Michael J.Maples-Keller, JessicaMarmar, CharlesMartin, Alicia R.Martin, Nicholas G.Maurer, DouglasMavissakalian, Matig R.McFarlane, AlexanderMcGlinchey, Regina E.McLaughlin, Katie A.McLean, Samuel A.McLeay, SarahMehta, DivyaMilberg, William P.Miller, Mark W.Morey, Rajendra A.Morris, Charles PhillipMors, OleMortensen, Preben B.Neale, Benjamin M.Nelson, Elliot C.Nordentoft, MereteNorman, Sonya B.O’Donnell, MeaghanOrcutt, Holly K.Panizzon, Matthew S.Peters, Edward S.Peterson, Alan L.Peverill, MatthewPietrzak, Robert H.Polusny, Melissa A.Rice, John P.Ripke, StephanRisbrough, Victoria B.Roberts, Andrea L.Rothbaum, Alex O.Rothbaum, Barbara O.Roy-Byrne, PeterRuggiero, KenRung, ArianeRutten, Bart P.F.Saccone, Nancy L.Sanchez, Sixto E.Schijven, DickSeedat, SorayaSeligowski, Antonia V.Seng, Julia S.Sheerin, Christina M.Silove, DerrickSmith, Alicia K.Smoller, Jordan W.Solovieff, NadiaSponheim, Scott R.Stein, Dan J.Sumner, Jennifer A.Teicher, Martin H.Thompson, Wesley K.Trapido, EdwardUddin, MonicaUrsano, Robert J.van den Heuvel, Leigh Luellavan Hooff, MirandaVermetten, EricVinkers, Christiaan H.Voisey, JoanneWang, YunpengWang, ZhewuWerge, ThomasWilliams, Michelle A.Williamson, Douglas E.Winternitz, SherryWolf, ChristianeWolf, Erika J.Wolff, Jonathan D.Yehuda, RachelYoung, Keith A.Young, Ross Mc D.Zhao, HongyuZoellner, Lori A.Liberzon, IsraelRessler, Kerry J.Haas, MagaliKoenen, Karestan C.2024-02-22T00:11:40Z2024-01-312024-01-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/163915eng2158-3188PURE: 83869053https://doi.org/10.1038/s41398-024-02765-7info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:49:34Zoai:run.unl.pt:10362/163915Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:55.880788Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Potential causal association between gut microbiome and posttraumatic stress disorder |
title |
Potential causal association between gut microbiome and posttraumatic stress disorder |
spellingShingle |
Potential causal association between gut microbiome and posttraumatic stress disorder He, Qiang Psychiatry and Mental health Cellular and Molecular Neuroscience Biological Psychiatry SDG 3 - Good Health and Well-being |
title_short |
Potential causal association between gut microbiome and posttraumatic stress disorder |
title_full |
Potential causal association between gut microbiome and posttraumatic stress disorder |
title_fullStr |
Potential causal association between gut microbiome and posttraumatic stress disorder |
title_full_unstemmed |
Potential causal association between gut microbiome and posttraumatic stress disorder |
title_sort |
Potential causal association between gut microbiome and posttraumatic stress disorder |
author |
He, Qiang |
author_facet |
He, Qiang Wang, Wenjing Xu, Dingkang Xiong, Yang Tao, Chuanyuan You, Chao Ma, Lu Ma, Junpeng Nievergelt, Caroline M. Maihofer, Adam X. Klengel, Torsten Atkinson, Elizabeth G. Chen, Chia Yen Choi, Karmel W. Coleman, Jonathan R.I. Dalvie, Shareefa Duncan, Laramie E. Logue, Mark W. Provost, Allison C. Ratanatharathorn, Andrew Stein, Murray B. Torres, Katy Aiello, Allison E. Almli, Lynn M. Amstadter, Ananda B. Andersen, Søren B. Andreassen, Ole A. Arbisi, Paul A. Ashley-Koch, Allison E. Austin, S. Bryn Avdibegovic, Esmina Babić, Dragan Bækvad-Hansen, Marie Baker, Dewleen G. Beckham, Jean C. Bierut, Laura J. Bisson, Jonathan I. Boks, Marco P. Bolger, Elizabeth A. Børglum, Anders D. Bradley, Bekh Brashear, Megan Breen, Gerome Bryant, Richard A. Bustamante, Angela C. Bybjerg-Grauholm, Jonas Calabrese, Joseph R. Caldas-de-Almeida, José M. Dale, Anders M. Daly, Mark J. Daskalakis, Nikolaos P. Deckert, Jürgen Delahanty, Douglas L. Dennis, Michelle F. Disner, Seth G. Domschke, Katharina Dzubur-Kulenovic, Alma Erbes, Christopher R. Evans, Alexandra Farrer, Lindsay A. Feeny, Norah C. Flory, Janine D. Forbes, David Franz, Carol E. Galea, Sandro Garrett, Melanie E. Gelaye, Bizu Gelernter, Joel Geuze, Elbert Gillespie, Charles Uka, Aferdita Goci Gordon, Scott D. Guffanti, Guia Hammamieh, Rasha Harnal, Supriya Hauser, Michael A. Heath, Andrew C. Hemmings, Sian M.J. Hougaard, David Michael Jakovljevic, Miro Jett, Marti Johnson, Eric Otto Jones, Ian Jovanovic, Tanja Qin, Xue Jun Junglen, Angela G. Karstoft, Karen Inge Kaufman, Milissa L. Kessler, Ronald C. Khan, Alaptagin Kimbrel, Nathan A. King, Anthony P. Koen, Nastassja Kranzler, Henry R. Kremen, William S. Lawford, Bruce R. Lebois, Lauren A.M. Lewis, Catrin E. Linnstaedt, Sarah D. Lori, Adriana Lugonja, Bozo Luykx, Jurjen J. Lyons, Michael J. Maples-Keller, Jessica Marmar, Charles Martin, Alicia R. Martin, Nicholas G. Maurer, Douglas Mavissakalian, Matig R. McFarlane, Alexander McGlinchey, Regina E. McLaughlin, Katie A. McLean, Samuel A. McLeay, Sarah Mehta, Divya Milberg, William P. Miller, Mark W. Morey, Rajendra A. Morris, Charles Phillip Mors, Ole Mortensen, Preben B. Neale, Benjamin M. Nelson, Elliot C. Nordentoft, Merete Norman, Sonya B. O’Donnell, Meaghan Orcutt, Holly K. Panizzon, Matthew S. Peters, Edward S. Peterson, Alan L. Peverill, Matthew Pietrzak, Robert H. Polusny, Melissa A. Rice, John P. Ripke, Stephan Risbrough, Victoria B. Roberts, Andrea L. Rothbaum, Alex O. Rothbaum, Barbara O. Roy-Byrne, Peter Ruggiero, Ken Rung, Ariane Rutten, Bart P.F. Saccone, Nancy L. Sanchez, Sixto E. Schijven, Dick Seedat, Soraya Seligowski, Antonia V. Seng, Julia S. Sheerin, Christina M. Silove, Derrick Smith, Alicia K. Smoller, Jordan W. Solovieff, Nadia Sponheim, Scott R. Stein, Dan J. Sumner, Jennifer A. Teicher, Martin H. Thompson, Wesley K. Trapido, Edward Uddin, Monica Ursano, Robert J. van den Heuvel, Leigh Luella van Hooff, Miranda Vermetten, Eric Vinkers, Christiaan H. Voisey, Joanne Wang, Yunpeng Wang, Zhewu Werge, Thomas Williams, Michelle A. Williamson, Douglas E. Winternitz, Sherry Wolf, Christiane Wolf, Erika J. Wolff, Jonathan D. Yehuda, Rachel Young, Keith A. Young, Ross Mc D. Zhao, Hongyu Zoellner, Lori A. Liberzon, Israel Ressler, Kerry J. Haas, Magali Koenen, Karestan C. |
author_role |
author |
author2 |
Wang, Wenjing Xu, Dingkang Xiong, Yang Tao, Chuanyuan You, Chao Ma, Lu Ma, Junpeng Nievergelt, Caroline M. Maihofer, Adam X. Klengel, Torsten Atkinson, Elizabeth G. Chen, Chia Yen Choi, Karmel W. Coleman, Jonathan R.I. Dalvie, Shareefa Duncan, Laramie E. Logue, Mark W. Provost, Allison C. Ratanatharathorn, Andrew Stein, Murray B. Torres, Katy Aiello, Allison E. Almli, Lynn M. Amstadter, Ananda B. Andersen, Søren B. Andreassen, Ole A. Arbisi, Paul A. Ashley-Koch, Allison E. Austin, S. Bryn Avdibegovic, Esmina Babić, Dragan Bækvad-Hansen, Marie Baker, Dewleen G. Beckham, Jean C. Bierut, Laura J. Bisson, Jonathan I. Boks, Marco P. Bolger, Elizabeth A. Børglum, Anders D. Bradley, Bekh Brashear, Megan Breen, Gerome Bryant, Richard A. Bustamante, Angela C. Bybjerg-Grauholm, Jonas Calabrese, Joseph R. Caldas-de-Almeida, José M. Dale, Anders M. Daly, Mark J. Daskalakis, Nikolaos P. Deckert, Jürgen Delahanty, Douglas L. Dennis, Michelle F. Disner, Seth G. Domschke, Katharina Dzubur-Kulenovic, Alma Erbes, Christopher R. Evans, Alexandra Farrer, Lindsay A. Feeny, Norah C. Flory, Janine D. Forbes, David Franz, Carol E. Galea, Sandro Garrett, Melanie E. Gelaye, Bizu Gelernter, Joel Geuze, Elbert Gillespie, Charles Uka, Aferdita Goci Gordon, Scott D. Guffanti, Guia Hammamieh, Rasha Harnal, Supriya Hauser, Michael A. Heath, Andrew C. Hemmings, Sian M.J. Hougaard, David Michael Jakovljevic, Miro Jett, Marti Johnson, Eric Otto Jones, Ian Jovanovic, Tanja Qin, Xue Jun Junglen, Angela G. Karstoft, Karen Inge Kaufman, Milissa L. Kessler, Ronald C. Khan, Alaptagin Kimbrel, Nathan A. King, Anthony P. Koen, Nastassja Kranzler, Henry R. Kremen, William S. Lawford, Bruce R. Lebois, Lauren A.M. Lewis, Catrin E. Linnstaedt, Sarah D. Lori, Adriana Lugonja, Bozo Luykx, Jurjen J. Lyons, Michael J. Maples-Keller, Jessica Marmar, Charles Martin, Alicia R. Martin, Nicholas G. Maurer, Douglas Mavissakalian, Matig R. McFarlane, Alexander McGlinchey, Regina E. McLaughlin, Katie A. McLean, Samuel A. McLeay, Sarah Mehta, Divya Milberg, William P. Miller, Mark W. Morey, Rajendra A. Morris, Charles Phillip Mors, Ole Mortensen, Preben B. Neale, Benjamin M. Nelson, Elliot C. Nordentoft, Merete Norman, Sonya B. O’Donnell, Meaghan Orcutt, Holly K. Panizzon, Matthew S. Peters, Edward S. Peterson, Alan L. Peverill, Matthew Pietrzak, Robert H. Polusny, Melissa A. Rice, John P. Ripke, Stephan Risbrough, Victoria B. Roberts, Andrea L. Rothbaum, Alex O. Rothbaum, Barbara O. Roy-Byrne, Peter Ruggiero, Ken Rung, Ariane Rutten, Bart P.F. Saccone, Nancy L. Sanchez, Sixto E. Schijven, Dick Seedat, Soraya Seligowski, Antonia V. Seng, Julia S. Sheerin, Christina M. Silove, Derrick Smith, Alicia K. Smoller, Jordan W. Solovieff, Nadia Sponheim, Scott R. Stein, Dan J. Sumner, Jennifer A. Teicher, Martin H. Thompson, Wesley K. Trapido, Edward Uddin, Monica Ursano, Robert J. van den Heuvel, Leigh Luella van Hooff, Miranda Vermetten, Eric Vinkers, Christiaan H. Voisey, Joanne Wang, Yunpeng Wang, Zhewu Werge, Thomas Williams, Michelle A. Williamson, Douglas E. Winternitz, Sherry Wolf, Christiane Wolf, Erika J. Wolff, Jonathan D. Yehuda, Rachel Young, Keith A. Young, Ross Mc D. Zhao, Hongyu Zoellner, Lori A. Liberzon, Israel Ressler, Kerry J. Haas, Magali Koenen, Karestan C. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
He, Qiang Wang, Wenjing Xu, Dingkang Xiong, Yang Tao, Chuanyuan You, Chao Ma, Lu Ma, Junpeng Nievergelt, Caroline M. Maihofer, Adam X. Klengel, Torsten Atkinson, Elizabeth G. Chen, Chia Yen Choi, Karmel W. Coleman, Jonathan R.I. Dalvie, Shareefa Duncan, Laramie E. Logue, Mark W. Provost, Allison C. Ratanatharathorn, Andrew Stein, Murray B. Torres, Katy Aiello, Allison E. Almli, Lynn M. Amstadter, Ananda B. Andersen, Søren B. Andreassen, Ole A. Arbisi, Paul A. Ashley-Koch, Allison E. Austin, S. Bryn Avdibegovic, Esmina Babić, Dragan Bækvad-Hansen, Marie Baker, Dewleen G. Beckham, Jean C. Bierut, Laura J. Bisson, Jonathan I. Boks, Marco P. Bolger, Elizabeth A. Børglum, Anders D. Bradley, Bekh Brashear, Megan Breen, Gerome Bryant, Richard A. Bustamante, Angela C. Bybjerg-Grauholm, Jonas Calabrese, Joseph R. Caldas-de-Almeida, José M. Dale, Anders M. Daly, Mark J. Daskalakis, Nikolaos P. Deckert, Jürgen Delahanty, Douglas L. Dennis, Michelle F. Disner, Seth G. Domschke, Katharina Dzubur-Kulenovic, Alma Erbes, Christopher R. Evans, Alexandra Farrer, Lindsay A. Feeny, Norah C. Flory, Janine D. Forbes, David Franz, Carol E. Galea, Sandro Garrett, Melanie E. Gelaye, Bizu Gelernter, Joel Geuze, Elbert Gillespie, Charles Uka, Aferdita Goci Gordon, Scott D. Guffanti, Guia Hammamieh, Rasha Harnal, Supriya Hauser, Michael A. Heath, Andrew C. Hemmings, Sian M.J. Hougaard, David Michael Jakovljevic, Miro Jett, Marti Johnson, Eric Otto Jones, Ian Jovanovic, Tanja Qin, Xue Jun Junglen, Angela G. Karstoft, Karen Inge Kaufman, Milissa L. Kessler, Ronald C. Khan, Alaptagin Kimbrel, Nathan A. King, Anthony P. Koen, Nastassja Kranzler, Henry R. Kremen, William S. Lawford, Bruce R. Lebois, Lauren A.M. Lewis, Catrin E. Linnstaedt, Sarah D. Lori, Adriana Lugonja, Bozo Luykx, Jurjen J. Lyons, Michael J. Maples-Keller, Jessica Marmar, Charles Martin, Alicia R. Martin, Nicholas G. Maurer, Douglas Mavissakalian, Matig R. McFarlane, Alexander McGlinchey, Regina E. McLaughlin, Katie A. McLean, Samuel A. McLeay, Sarah Mehta, Divya Milberg, William P. Miller, Mark W. Morey, Rajendra A. Morris, Charles Phillip Mors, Ole Mortensen, Preben B. Neale, Benjamin M. Nelson, Elliot C. Nordentoft, Merete Norman, Sonya B. O’Donnell, Meaghan Orcutt, Holly K. Panizzon, Matthew S. Peters, Edward S. Peterson, Alan L. Peverill, Matthew Pietrzak, Robert H. Polusny, Melissa A. Rice, John P. Ripke, Stephan Risbrough, Victoria B. Roberts, Andrea L. Rothbaum, Alex O. Rothbaum, Barbara O. Roy-Byrne, Peter Ruggiero, Ken Rung, Ariane Rutten, Bart P.F. Saccone, Nancy L. Sanchez, Sixto E. Schijven, Dick Seedat, Soraya Seligowski, Antonia V. Seng, Julia S. Sheerin, Christina M. Silove, Derrick Smith, Alicia K. Smoller, Jordan W. Solovieff, Nadia Sponheim, Scott R. Stein, Dan J. Sumner, Jennifer A. Teicher, Martin H. Thompson, Wesley K. Trapido, Edward Uddin, Monica Ursano, Robert J. van den Heuvel, Leigh Luella van Hooff, Miranda Vermetten, Eric Vinkers, Christiaan H. Voisey, Joanne Wang, Yunpeng Wang, Zhewu Werge, Thomas Williams, Michelle A. Williamson, Douglas E. Winternitz, Sherry Wolf, Christiane Wolf, Erika J. Wolff, Jonathan D. Yehuda, Rachel Young, Keith A. Young, Ross Mc D. Zhao, Hongyu Zoellner, Lori A. Liberzon, Israel Ressler, Kerry J. Haas, Magali Koenen, Karestan C. |
dc.subject.por.fl_str_mv |
Psychiatry and Mental health Cellular and Molecular Neuroscience Biological Psychiatry SDG 3 - Good Health and Well-being |
topic |
Psychiatry and Mental health Cellular and Molecular Neuroscience Biological Psychiatry SDG 3 - Good Health and Well-being |
description |
Funding Information: We thank the participants and working staff including the Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group, the FinnGen consortium, and the MiBioGen consortium. Publisher Copyright: © 2024, The Author(s). |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-02-22T00:11:40Z 2024-01-31 2024-01-31T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/163915 |
url |
http://hdl.handle.net/10362/163915 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2158-3188 PURE: 83869053 https://doi.org/10.1038/s41398-024-02765-7 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138175844614144 |