Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/57941 |
Resumo: | We investigated the spatial epidemiology of bovine tuberculosis (TB) in wildlife in a multihost system. We surveyed bovine TB in Portugal by serologic analysis of elutes of dried blood spots obtained from hunted wild boar. We modeled spatial disease risk by using areal generalized linear mixed models with conditional autoregressive priors. Antibodies against Mycobaterium bovis were detected in 2.4% (95% CI 1.5%-3.8%) of 678 wild boar in 2 geographic clusters, and the predicted risk fits well with independent reports of M. bovis culture. Results show that elutes are an almost perfect substitute for serum (Cohen unweighted κ = 0.818), indicating that serologic tests coupled with dried blood spots are an effective strategy for large-scale bovine TB surveys, using wild boar as sentinel species. Results also show that bovine TB is an emerging wildlife disease and stress the need to prevent further geographic spread and prevalence increase. |
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Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, PortugalWildlife tuberculosisBovine tuberculosisMycobacterium bovisBacteriaTuberculosis and other mycobacteriaRespiratory infectionsEpidemiologic surveillanceSerologic surveyDried blood spotsSpatial epidemiologyCattleWild boarRed deerWild animalsZoonoses, PortugalPortugalCiências Médicas::Medicina BásicaScience & TechnologyWe investigated the spatial epidemiology of bovine tuberculosis (TB) in wildlife in a multihost system. We surveyed bovine TB in Portugal by serologic analysis of elutes of dried blood spots obtained from hunted wild boar. We modeled spatial disease risk by using areal generalized linear mixed models with conditional autoregressive priors. Antibodies against Mycobaterium bovis were detected in 2.4% (95% CI 1.5%-3.8%) of 678 wild boar in 2 geographic clusters, and the predicted risk fits well with independent reports of M. bovis culture. Results show that elutes are an almost perfect substitute for serum (Cohen unweighted κ = 0.818), indicating that serologic tests coupled with dried blood spots are an effective strategy for large-scale bovine TB surveys, using wild boar as sentinel species. Results also show that bovine TB is an emerging wildlife disease and stress the need to prevent further geographic spread and prevalence increase.Plan Nacional (grant CGL2017-89866 from the Ministry of Economy and Competitiveness, Spain, and Fondo Europeo de Desarollo Regional) and Programa Operacional Regional do Norte (grant ON.2 O Novo Norte), Quadro de Referência Estratégico Nacional through the Fundo Europeu de Desenvolvimento Regional. N.S. was supported by PhD grant SFRH/BD/69390/2010 from Fundação para a Ciência e Tecnologiainfo:eu-repo/semantics/publishedVersionCenters for Disease Control and Prevention (CDC)Universidade do MinhoSantos, NunoNunes, TelmoFonseca, CarlosVieira-Pinto, MadalenaAlmeida, VirgílioGortázar, ChristianCorreia-Neves, M2018-122018-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/57941engSantos, N., Nunes, T., Fonseca, C., Vieira-Pinto, M., Almeida, V., Gortázar, C., & Correia-Neves, M. (2018). Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal. Emerging infectious diseases, 24(12), 21691080-604010.3201/eid2412.17135730457522https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256377/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:06:30Zoai:repositorium.sdum.uminho.pt:1822/57941Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:57:12.353107Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal |
title |
Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal |
spellingShingle |
Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal Santos, Nuno Wildlife tuberculosis Bovine tuberculosis Mycobacterium bovis Bacteria Tuberculosis and other mycobacteria Respiratory infections Epidemiologic surveillance Serologic survey Dried blood spots Spatial epidemiology Cattle Wild boar Red deer Wild animals Zoonoses, Portugal Portugal Ciências Médicas::Medicina Básica Science & Technology |
title_short |
Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal |
title_full |
Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal |
title_fullStr |
Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal |
title_full_unstemmed |
Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal |
title_sort |
Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal |
author |
Santos, Nuno |
author_facet |
Santos, Nuno Nunes, Telmo Fonseca, Carlos Vieira-Pinto, Madalena Almeida, Virgílio Gortázar, Christian Correia-Neves, M |
author_role |
author |
author2 |
Nunes, Telmo Fonseca, Carlos Vieira-Pinto, Madalena Almeida, Virgílio Gortázar, Christian Correia-Neves, M |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Santos, Nuno Nunes, Telmo Fonseca, Carlos Vieira-Pinto, Madalena Almeida, Virgílio Gortázar, Christian Correia-Neves, M |
dc.subject.por.fl_str_mv |
Wildlife tuberculosis Bovine tuberculosis Mycobacterium bovis Bacteria Tuberculosis and other mycobacteria Respiratory infections Epidemiologic surveillance Serologic survey Dried blood spots Spatial epidemiology Cattle Wild boar Red deer Wild animals Zoonoses, Portugal Portugal Ciências Médicas::Medicina Básica Science & Technology |
topic |
Wildlife tuberculosis Bovine tuberculosis Mycobacterium bovis Bacteria Tuberculosis and other mycobacteria Respiratory infections Epidemiologic surveillance Serologic survey Dried blood spots Spatial epidemiology Cattle Wild boar Red deer Wild animals Zoonoses, Portugal Portugal Ciências Médicas::Medicina Básica Science & Technology |
description |
We investigated the spatial epidemiology of bovine tuberculosis (TB) in wildlife in a multihost system. We surveyed bovine TB in Portugal by serologic analysis of elutes of dried blood spots obtained from hunted wild boar. We modeled spatial disease risk by using areal generalized linear mixed models with conditional autoregressive priors. Antibodies against Mycobaterium bovis were detected in 2.4% (95% CI 1.5%-3.8%) of 678 wild boar in 2 geographic clusters, and the predicted risk fits well with independent reports of M. bovis culture. Results show that elutes are an almost perfect substitute for serum (Cohen unweighted κ = 0.818), indicating that serologic tests coupled with dried blood spots are an effective strategy for large-scale bovine TB surveys, using wild boar as sentinel species. Results also show that bovine TB is an emerging wildlife disease and stress the need to prevent further geographic spread and prevalence increase. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12 2018-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/57941 |
url |
http://hdl.handle.net/1822/57941 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Santos, N., Nunes, T., Fonseca, C., Vieira-Pinto, M., Almeida, V., Gortázar, C., & Correia-Neves, M. (2018). Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal. Emerging infectious diseases, 24(12), 2169 1080-6040 10.3201/eid2412.171357 30457522 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256377/ |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Centers for Disease Control and Prevention (CDC) |
publisher.none.fl_str_mv |
Centers for Disease Control and Prevention (CDC) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132360944386048 |