Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal

Detalhes bibliográficos
Autor(a) principal: Santos, Nuno
Data de Publicação: 2018
Outros Autores: Nunes, Telmo, Fonseca, Carlos, Vieira-Pinto, Madalena, Almeida, Virgílio, Gortázar, Christian, Correia-Neves, M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/57941
Resumo: We investigated the spatial epidemiology of bovine tuberculosis (TB) in wildlife in a multihost system. We surveyed bovine TB in Portugal by serologic analysis of elutes of dried blood spots obtained from hunted wild boar. We modeled spatial disease risk by using areal generalized linear mixed models with conditional autoregressive priors. Antibodies against Mycobaterium bovis were detected in 2.4% (95% CI 1.5%-3.8%) of 678 wild boar in 2 geographic clusters, and the predicted risk fits well with independent reports of M. bovis culture. Results show that elutes are an almost perfect substitute for serum (Cohen unweighted κ = 0.818), indicating that serologic tests coupled with dried blood spots are an effective strategy for large-scale bovine TB surveys, using wild boar as sentinel species. Results also show that bovine TB is an emerging wildlife disease and stress the need to prevent further geographic spread and prevalence increase.
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spelling Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, PortugalWildlife tuberculosisBovine tuberculosisMycobacterium bovisBacteriaTuberculosis and other mycobacteriaRespiratory infectionsEpidemiologic surveillanceSerologic surveyDried blood spotsSpatial epidemiologyCattleWild boarRed deerWild animalsZoonoses, PortugalPortugalCiências Médicas::Medicina BásicaScience & TechnologyWe investigated the spatial epidemiology of bovine tuberculosis (TB) in wildlife in a multihost system. We surveyed bovine TB in Portugal by serologic analysis of elutes of dried blood spots obtained from hunted wild boar. We modeled spatial disease risk by using areal generalized linear mixed models with conditional autoregressive priors. Antibodies against Mycobaterium bovis were detected in 2.4% (95% CI 1.5%-3.8%) of 678 wild boar in 2 geographic clusters, and the predicted risk fits well with independent reports of M. bovis culture. Results show that elutes are an almost perfect substitute for serum (Cohen unweighted κ = 0.818), indicating that serologic tests coupled with dried blood spots are an effective strategy for large-scale bovine TB surveys, using wild boar as sentinel species. Results also show that bovine TB is an emerging wildlife disease and stress the need to prevent further geographic spread and prevalence increase.Plan Nacional (grant CGL2017-89866 from the Ministry of Economy and Competitiveness, Spain, and Fondo Europeo de Desarollo Regional) and Programa Operacional Regional do Norte (grant ON.2 O Novo Norte), Quadro de Referência Estratégico Nacional through the Fundo Europeu de Desenvolvimento Regional. N.S. was supported by PhD grant SFRH/BD/69390/2010 from Fundação para a Ciência e Tecnologiainfo:eu-repo/semantics/publishedVersionCenters for Disease Control and Prevention (CDC)Universidade do MinhoSantos, NunoNunes, TelmoFonseca, CarlosVieira-Pinto, MadalenaAlmeida, VirgílioGortázar, ChristianCorreia-Neves, M2018-122018-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/57941engSantos, N., Nunes, T., Fonseca, C., Vieira-Pinto, M., Almeida, V., Gortázar, C., & Correia-Neves, M. (2018). Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal. Emerging infectious diseases, 24(12), 21691080-604010.3201/eid2412.17135730457522https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256377/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T04:53:29Zoai:repositorium.sdum.uminho.pt:1822/57941Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T04:53:29Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal
title Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal
spellingShingle Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal
Santos, Nuno
Wildlife tuberculosis
Bovine tuberculosis
Mycobacterium bovis
Bacteria
Tuberculosis and other mycobacteria
Respiratory infections
Epidemiologic surveillance
Serologic survey
Dried blood spots
Spatial epidemiology
Cattle
Wild boar
Red deer
Wild animals
Zoonoses, Portugal
Portugal
Ciências Médicas::Medicina Básica
Science & Technology
title_short Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal
title_full Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal
title_fullStr Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal
title_full_unstemmed Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal
title_sort Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal
author Santos, Nuno
author_facet Santos, Nuno
Nunes, Telmo
Fonseca, Carlos
Vieira-Pinto, Madalena
Almeida, Virgílio
Gortázar, Christian
Correia-Neves, M
author_role author
author2 Nunes, Telmo
Fonseca, Carlos
Vieira-Pinto, Madalena
Almeida, Virgílio
Gortázar, Christian
Correia-Neves, M
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Santos, Nuno
Nunes, Telmo
Fonseca, Carlos
Vieira-Pinto, Madalena
Almeida, Virgílio
Gortázar, Christian
Correia-Neves, M
dc.subject.por.fl_str_mv Wildlife tuberculosis
Bovine tuberculosis
Mycobacterium bovis
Bacteria
Tuberculosis and other mycobacteria
Respiratory infections
Epidemiologic surveillance
Serologic survey
Dried blood spots
Spatial epidemiology
Cattle
Wild boar
Red deer
Wild animals
Zoonoses, Portugal
Portugal
Ciências Médicas::Medicina Básica
Science & Technology
topic Wildlife tuberculosis
Bovine tuberculosis
Mycobacterium bovis
Bacteria
Tuberculosis and other mycobacteria
Respiratory infections
Epidemiologic surveillance
Serologic survey
Dried blood spots
Spatial epidemiology
Cattle
Wild boar
Red deer
Wild animals
Zoonoses, Portugal
Portugal
Ciências Médicas::Medicina Básica
Science & Technology
description We investigated the spatial epidemiology of bovine tuberculosis (TB) in wildlife in a multihost system. We surveyed bovine TB in Portugal by serologic analysis of elutes of dried blood spots obtained from hunted wild boar. We modeled spatial disease risk by using areal generalized linear mixed models with conditional autoregressive priors. Antibodies against Mycobaterium bovis were detected in 2.4% (95% CI 1.5%-3.8%) of 678 wild boar in 2 geographic clusters, and the predicted risk fits well with independent reports of M. bovis culture. Results show that elutes are an almost perfect substitute for serum (Cohen unweighted κ = 0.818), indicating that serologic tests coupled with dried blood spots are an effective strategy for large-scale bovine TB surveys, using wild boar as sentinel species. Results also show that bovine TB is an emerging wildlife disease and stress the need to prevent further geographic spread and prevalence increase.
publishDate 2018
dc.date.none.fl_str_mv 2018-12
2018-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/57941
url http://hdl.handle.net/1822/57941
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Santos, N., Nunes, T., Fonseca, C., Vieira-Pinto, M., Almeida, V., Gortázar, C., & Correia-Neves, M. (2018). Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal. Emerging infectious diseases, 24(12), 2169
1080-6040
10.3201/eid2412.171357
30457522
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256377/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Centers for Disease Control and Prevention (CDC)
publisher.none.fl_str_mv Centers for Disease Control and Prevention (CDC)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817544449899626496

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