Immune tumor microenvironment in ovarian cancer ascites

Detalhes bibliográficos
Autor(a) principal: Almeida-Nunes, Diana Luísa
Data de Publicação: 2022
Outros Autores: Frias, Ana Isabel Mendes, Silvestre, Ricardo Jorge Leal, Dinis-Oliveira, Ricardo Jorge, Ricardo, Sara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/80788
Resumo: Ovarian cancer (OC) has a specific type of metastasis, via transcoelomic, and most of the patients are diagnosed at advanced stages with multiple tumors spread within the peritoneal cavity. The role of Malignant Ascites (MA) is to serve as a transporter of tumor cells from the primary location to the peritoneal wall or to the surface of the peritoneal organs. MA comprise cellular components with tumor and non-tumor cells and acellular components, creating a unique microenvironment capable of modifying the tumor behavior. These microenvironment factors influence tumor cell proliferation, progression, chemoresistance, and immune evasion, suggesting that MA play an active role in OC progression. Tumor cells induce a complex immune suppression that neutralizes antitumor immunity, leading to disease progression and treatment failure, provoking a tumor-promoting environment. In this review, we will focus on the High-Grade Serous Carcinoma (HGSC) microenvironment with special attention to the tumor microenvironment immunology.
id RCAP_66b38ca9a8573669edd1d9897c947ead
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/80788
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Immune tumor microenvironment in ovarian cancer ascitesOvarian cancerMalignant ascitesTumor microenvironmentImmune cellsCytokinesHigh-grade serous carcinomaScience & TechnologyOvarian cancer (OC) has a specific type of metastasis, via transcoelomic, and most of the patients are diagnosed at advanced stages with multiple tumors spread within the peritoneal cavity. The role of Malignant Ascites (MA) is to serve as a transporter of tumor cells from the primary location to the peritoneal wall or to the surface of the peritoneal organs. MA comprise cellular components with tumor and non-tumor cells and acellular components, creating a unique microenvironment capable of modifying the tumor behavior. These microenvironment factors influence tumor cell proliferation, progression, chemoresistance, and immune evasion, suggesting that MA play an active role in OC progression. Tumor cells induce a complex immune suppression that neutralizes antitumor immunity, leading to disease progression and treatment failure, provoking a tumor-promoting environment. In this review, we will focus on the High-Grade Serous Carcinoma (HGSC) microenvironment with special attention to the tumor microenvironment immunology.This work was supported by Fundacão para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior and European Union through a PhD fellowship (2021.05081.BD) cosponsored by Fundo Social Europeu (FSE) through Programa Operacional Regional Norte (Norte 2020).Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoAlmeida-Nunes, Diana LuísaFrias, Ana Isabel MendesSilvestre, Ricardo Jorge LealDinis-Oliveira, Ricardo JorgeRicardo, Sara2022-09-142022-09-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/80788engAlmeida-Nunes, D.L.; Mendes-Frias, A.; Silvestre, R.; Dinis-Oliveira, R.J.; Ricardo, S. Immune Tumor Microenvironment in Ovarian Cancer Ascites. Int. J. Mol. Sci. 2022, 23, 10692. https://doi.org/ 10.3390/ijms2318106921661-65961422-006710.3390/ijms2318106923614261510692https://www.mdpi.com/1422-0067/23/18/10692info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:53:54Zoai:repositorium.sdum.uminho.pt:1822/80788Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:53:23.830152Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Immune tumor microenvironment in ovarian cancer ascites
title Immune tumor microenvironment in ovarian cancer ascites
spellingShingle Immune tumor microenvironment in ovarian cancer ascites
Almeida-Nunes, Diana Luísa
Ovarian cancer
Malignant ascites
Tumor microenvironment
Immune cells
Cytokines
High-grade serous carcinoma
Science & Technology
title_short Immune tumor microenvironment in ovarian cancer ascites
title_full Immune tumor microenvironment in ovarian cancer ascites
title_fullStr Immune tumor microenvironment in ovarian cancer ascites
title_full_unstemmed Immune tumor microenvironment in ovarian cancer ascites
title_sort Immune tumor microenvironment in ovarian cancer ascites
author Almeida-Nunes, Diana Luísa
author_facet Almeida-Nunes, Diana Luísa
Frias, Ana Isabel Mendes
Silvestre, Ricardo Jorge Leal
Dinis-Oliveira, Ricardo Jorge
Ricardo, Sara
author_role author
author2 Frias, Ana Isabel Mendes
Silvestre, Ricardo Jorge Leal
Dinis-Oliveira, Ricardo Jorge
Ricardo, Sara
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Almeida-Nunes, Diana Luísa
Frias, Ana Isabel Mendes
Silvestre, Ricardo Jorge Leal
Dinis-Oliveira, Ricardo Jorge
Ricardo, Sara
dc.subject.por.fl_str_mv Ovarian cancer
Malignant ascites
Tumor microenvironment
Immune cells
Cytokines
High-grade serous carcinoma
Science & Technology
topic Ovarian cancer
Malignant ascites
Tumor microenvironment
Immune cells
Cytokines
High-grade serous carcinoma
Science & Technology
description Ovarian cancer (OC) has a specific type of metastasis, via transcoelomic, and most of the patients are diagnosed at advanced stages with multiple tumors spread within the peritoneal cavity. The role of Malignant Ascites (MA) is to serve as a transporter of tumor cells from the primary location to the peritoneal wall or to the surface of the peritoneal organs. MA comprise cellular components with tumor and non-tumor cells and acellular components, creating a unique microenvironment capable of modifying the tumor behavior. These microenvironment factors influence tumor cell proliferation, progression, chemoresistance, and immune evasion, suggesting that MA play an active role in OC progression. Tumor cells induce a complex immune suppression that neutralizes antitumor immunity, leading to disease progression and treatment failure, provoking a tumor-promoting environment. In this review, we will focus on the High-Grade Serous Carcinoma (HGSC) microenvironment with special attention to the tumor microenvironment immunology.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-14
2022-09-14T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/80788
url https://hdl.handle.net/1822/80788
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Almeida-Nunes, D.L.; Mendes-Frias, A.; Silvestre, R.; Dinis-Oliveira, R.J.; Ricardo, S. Immune Tumor Microenvironment in Ovarian Cancer Ascites. Int. J. Mol. Sci. 2022, 23, 10692. https://doi.org/ 10.3390/ijms231810692
1661-6596
1422-0067
10.3390/ijms231810692
36142615
10692
https://www.mdpi.com/1422-0067/23/18/10692
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133129363947520

Registros relacionados