Triple negative breast cancer: nanosolutions for a big challenge

Detalhes bibliográficos
Autor(a) principal: Mendes, T.
Data de Publicação: 2015
Outros Autores: Kluskens, Leon, Rodrigues, L. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/38393
Resumo: Triple negative breast cancer (TNBC) is a particular immunopathological subtype of breast cancer that lacks expression of estrogen and progesterone receptors (ER/PR) and amplification of the human epidermal growth factor receptor 2 (HER2) gene. Characterized by aggressive and metastatic phenotypes and high rates of relapse, TNBC is the only breast cancer subgroup still lacking effective therapeutic options, thus presenting the worst prognosis. The development of targeted therapies, as well as early diagnosis methods, is vital to ensure an adequate and timely therapeutic intervention in patients with TNBC. This review intends to discuss potentially emerging approaches for the diagnosis and treatment of TNBC patients, with a special focus on nano-based solutions that actively target these particular tumors.
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spelling Triple negative breast cancer: nanosolutions for a big challengenanotechnologydrug deliverydiagnosticscancer therapytriple negative breast cancer (TNBC)Science & TechnologyTriple negative breast cancer (TNBC) is a particular immunopathological subtype of breast cancer that lacks expression of estrogen and progesterone receptors (ER/PR) and amplification of the human epidermal growth factor receptor 2 (HER2) gene. Characterized by aggressive and metastatic phenotypes and high rates of relapse, TNBC is the only breast cancer subgroup still lacking effective therapeutic options, thus presenting the worst prognosis. The development of targeted therapies, as well as early diagnosis methods, is vital to ensure an adequate and timely therapeutic intervention in patients with TNBC. This review intends to discuss potentially emerging approaches for the diagnosis and treatment of TNBC patients, with a special focus on nano-based solutions that actively target these particular tumors.his study was supported by the Portuguese Foundation for Science and Technology (FCT) and the European Community fund FEDER, through Program COMPETE, under the scope of the Projects FCOMP01–0124-FEDER -0 21053 (PTDC/ SAU-BMA/121028/2010), PEst-OE/ EQB/LA0023/2013, RECI/BBB-EBI/0179/2012 (FCOMP-01–0124FEDER-027462), the strategic funding of UID/BIO/04469/2013 unit, and the Projects “BioHealth – Biotechnology and Bioengineering approaches to improve health quality”, REF. NORTE-07–0124-FEDER-000027, and “BioInd – Biotechnology and Bioengineering for improved Industrial and Agro-Food processes”, REF. NORTE-07–0124-FEDER-000028, co-funded by the Programa Operacional Regional do Norte (ON.2 – O Novo Norte), QREN, FEDER. Tânia Mendes acknowledges the FCT for supporting her PhD grant (SFRH / BD / 51955 / 2012).Wiley-VCH VerlagUniversidade do MinhoMendes, T.Kluskens, LeonRodrigues, L. R.2015-112015-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/38393engMendes, T.; Kluskens, Leon; Rodrigues, L. R., Triple negative breast cancer: nanosolutions for a big challenge. Advanced Science, 2(11), 1-14, 20152198-38442198-384410.1002/advs.201500053http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:59:00Zoai:repositorium.sdum.uminho.pt:1822/38393Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:48:45.909200Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Triple negative breast cancer: nanosolutions for a big challenge
title Triple negative breast cancer: nanosolutions for a big challenge
spellingShingle Triple negative breast cancer: nanosolutions for a big challenge
Mendes, T.
nanotechnology
drug delivery
diagnostics
cancer therapy
triple negative breast cancer (TNBC)
Science & Technology
title_short Triple negative breast cancer: nanosolutions for a big challenge
title_full Triple negative breast cancer: nanosolutions for a big challenge
title_fullStr Triple negative breast cancer: nanosolutions for a big challenge
title_full_unstemmed Triple negative breast cancer: nanosolutions for a big challenge
title_sort Triple negative breast cancer: nanosolutions for a big challenge
author Mendes, T.
author_facet Mendes, T.
Kluskens, Leon
Rodrigues, L. R.
author_role author
author2 Kluskens, Leon
Rodrigues, L. R.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Mendes, T.
Kluskens, Leon
Rodrigues, L. R.
dc.subject.por.fl_str_mv nanotechnology
drug delivery
diagnostics
cancer therapy
triple negative breast cancer (TNBC)
Science & Technology
topic nanotechnology
drug delivery
diagnostics
cancer therapy
triple negative breast cancer (TNBC)
Science & Technology
description Triple negative breast cancer (TNBC) is a particular immunopathological subtype of breast cancer that lacks expression of estrogen and progesterone receptors (ER/PR) and amplification of the human epidermal growth factor receptor 2 (HER2) gene. Characterized by aggressive and metastatic phenotypes and high rates of relapse, TNBC is the only breast cancer subgroup still lacking effective therapeutic options, thus presenting the worst prognosis. The development of targeted therapies, as well as early diagnosis methods, is vital to ensure an adequate and timely therapeutic intervention in patients with TNBC. This review intends to discuss potentially emerging approaches for the diagnosis and treatment of TNBC patients, with a special focus on nano-based solutions that actively target these particular tumors.
publishDate 2015
dc.date.none.fl_str_mv 2015-11
2015-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/38393
url http://hdl.handle.net/1822/38393
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mendes, T.; Kluskens, Leon; Rodrigues, L. R., Triple negative breast cancer: nanosolutions for a big challenge. Advanced Science, 2(11), 1-14, 2015
2198-3844
2198-3844
10.1002/advs.201500053
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH Verlag
publisher.none.fl_str_mv Wiley-VCH Verlag
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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