A robust ex vivo method to evaluate the diffusion properties of agents in biological tissues

Detalhes bibliográficos
Autor(a) principal: Carneiro, Isa
Data de Publicação: 2019
Outros Autores: Carvalho, Sónia, Henrique, Rui, Oliveira, Luís, Tuchin, Valery V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/17166
Resumo: A robust method is presented for evaluating the diffusion properties of chemicals in ex vivo biological tissues. Using this method that relies only on thickness and collimated transmittance measurements, the diffusion properties of glycerol, fructose, polypropylene glycol and water in muscle tissues were evaluated. Amongst other results, the diffusion coefficient of glycerol in colorectal muscle was estimated with a value of 3.3 × 10-7 cm2 /s. Due to the robustness and simplicity of the method, it can be used in other fields of biomedical engineering, namely in organ cryoprotection and food industry.
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spelling A robust ex vivo method to evaluate the diffusion properties of agents in biological tissuesCollimated transmittanceColorectal tissuesDiffusion propertiesMuscleOptical clearingA robust method is presented for evaluating the diffusion properties of chemicals in ex vivo biological tissues. Using this method that relies only on thickness and collimated transmittance measurements, the diffusion properties of glycerol, fructose, polypropylene glycol and water in muscle tissues were evaluated. Amongst other results, the diffusion coefficient of glycerol in colorectal muscle was estimated with a value of 3.3 × 10-7 cm2 /s. Due to the robustness and simplicity of the method, it can be used in other fields of biomedical engineering, namely in organ cryoprotection and food industry.Ministry of Science and Higher Education of the Russian Federation, Grant/Award Number: 08‐08; Russian Foundation for Basic Research, Grant/Award Number: 17‐00‐00275 (17‐00‐00272); Portuguese Foundation for Science and Technology, Grant/Award Number: FCT‐UID/EQU/04730/2013WileyRepositório Científico do Instituto Politécnico do PortoCarneiro, IsaCarvalho, SóniaHenrique, RuiOliveira, LuísTuchin, Valery V.20192120-01-01T00:00:00Z2019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/17166eng10.1002/jbio.201800333metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:06:47Zoai:recipp.ipp.pt:10400.22/17166Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:36:51.102567Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A robust ex vivo method to evaluate the diffusion properties of agents in biological tissues
title A robust ex vivo method to evaluate the diffusion properties of agents in biological tissues
spellingShingle A robust ex vivo method to evaluate the diffusion properties of agents in biological tissues
Carneiro, Isa
Collimated transmittance
Colorectal tissues
Diffusion properties
Muscle
Optical clearing
title_short A robust ex vivo method to evaluate the diffusion properties of agents in biological tissues
title_full A robust ex vivo method to evaluate the diffusion properties of agents in biological tissues
title_fullStr A robust ex vivo method to evaluate the diffusion properties of agents in biological tissues
title_full_unstemmed A robust ex vivo method to evaluate the diffusion properties of agents in biological tissues
title_sort A robust ex vivo method to evaluate the diffusion properties of agents in biological tissues
author Carneiro, Isa
author_facet Carneiro, Isa
Carvalho, Sónia
Henrique, Rui
Oliveira, Luís
Tuchin, Valery V.
author_role author
author2 Carvalho, Sónia
Henrique, Rui
Oliveira, Luís
Tuchin, Valery V.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Carneiro, Isa
Carvalho, Sónia
Henrique, Rui
Oliveira, Luís
Tuchin, Valery V.
dc.subject.por.fl_str_mv Collimated transmittance
Colorectal tissues
Diffusion properties
Muscle
Optical clearing
topic Collimated transmittance
Colorectal tissues
Diffusion properties
Muscle
Optical clearing
description A robust method is presented for evaluating the diffusion properties of chemicals in ex vivo biological tissues. Using this method that relies only on thickness and collimated transmittance measurements, the diffusion properties of glycerol, fructose, polypropylene glycol and water in muscle tissues were evaluated. Amongst other results, the diffusion coefficient of glycerol in colorectal muscle was estimated with a value of 3.3 × 10-7 cm2 /s. Due to the robustness and simplicity of the method, it can be used in other fields of biomedical engineering, namely in organ cryoprotection and food industry.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2120-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/17166
url http://hdl.handle.net/10400.22/17166
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1002/jbio.201800333
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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