Clinical outcomes of 77 TESE treatment cycles in non-mosaic Klinefelter syndrome patients
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/139708 |
Resumo: | The aim of the present work was to present the clinical outcomes of 76 azoospermic patients with non-mosaic Klinefelter syndrome, treated by testicular sperm extraction (TESE) followed by intracytoplasmic sperm injection (ICSI), using either fresh or cryopreserved testicular spermatozoa. Spermatozoa were recovered in 31/77 (40.3%) of the TESE attempts. The mean male age was 34.1 years old. In most of the cases, the testicular volume was reduced (96.1%), the levels of FSH (98.3%) and LH (94.1%) were increased, and the levels of testosterone were normal (77.6%). There were 25 ICSI treatment cycles using fresh testicular spermatozoa and 22 ICSI treatment cycles using frozen testicular spermatozoa. The rates of fertilization (63.5% vs 41.6%), implantation (37% vs 13.2%), clinical pregnancy (60.9% vs 19%), live birth delivery (52.2% vs 19%) and newborn (65.2% vs 23.8%) were higher in the group using fresh testicular spermatozoa. Chromosome analysis of the 21 newborns was normal. In conclusion, the present data adds further information regarding the recovery rate of spermatozoa after TESE and the embryological and clinical outcomes, besides reassuring the safety concerning to abnormal chromosomal transmission to the children of Klinefelter fathers. |
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Clinical outcomes of 77 TESE treatment cycles in non-mosaic Klinefelter syndrome patientsMedicina clínicaClinical medicineThe aim of the present work was to present the clinical outcomes of 76 azoospermic patients with non-mosaic Klinefelter syndrome, treated by testicular sperm extraction (TESE) followed by intracytoplasmic sperm injection (ICSI), using either fresh or cryopreserved testicular spermatozoa. Spermatozoa were recovered in 31/77 (40.3%) of the TESE attempts. The mean male age was 34.1 years old. In most of the cases, the testicular volume was reduced (96.1%), the levels of FSH (98.3%) and LH (94.1%) were increased, and the levels of testosterone were normal (77.6%). There were 25 ICSI treatment cycles using fresh testicular spermatozoa and 22 ICSI treatment cycles using frozen testicular spermatozoa. The rates of fertilization (63.5% vs 41.6%), implantation (37% vs 13.2%), clinical pregnancy (60.9% vs 19%), live birth delivery (52.2% vs 19%) and newborn (65.2% vs 23.8%) were higher in the group using fresh testicular spermatozoa. Chromosome analysis of the 21 newborns was normal. In conclusion, the present data adds further information regarding the recovery rate of spermatozoa after TESE and the embryological and clinical outcomes, besides reassuring the safety concerning to abnormal chromosomal transmission to the children of Klinefelter fathers.2021-05-242021-05-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://hdl.handle.net/10216/139708TID:203178882engPedro Barbosa Soares Barros da Silvainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-27T07:11:02Zoai:repositorio-aberto.up.pt:10216/139708Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-27T07:11:02Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Clinical outcomes of 77 TESE treatment cycles in non-mosaic Klinefelter syndrome patients |
title |
Clinical outcomes of 77 TESE treatment cycles in non-mosaic Klinefelter syndrome patients |
spellingShingle |
Clinical outcomes of 77 TESE treatment cycles in non-mosaic Klinefelter syndrome patients Pedro Barbosa Soares Barros da Silva Medicina clínica Clinical medicine |
title_short |
Clinical outcomes of 77 TESE treatment cycles in non-mosaic Klinefelter syndrome patients |
title_full |
Clinical outcomes of 77 TESE treatment cycles in non-mosaic Klinefelter syndrome patients |
title_fullStr |
Clinical outcomes of 77 TESE treatment cycles in non-mosaic Klinefelter syndrome patients |
title_full_unstemmed |
Clinical outcomes of 77 TESE treatment cycles in non-mosaic Klinefelter syndrome patients |
title_sort |
Clinical outcomes of 77 TESE treatment cycles in non-mosaic Klinefelter syndrome patients |
author |
Pedro Barbosa Soares Barros da Silva |
author_facet |
Pedro Barbosa Soares Barros da Silva |
author_role |
author |
dc.contributor.author.fl_str_mv |
Pedro Barbosa Soares Barros da Silva |
dc.subject.por.fl_str_mv |
Medicina clínica Clinical medicine |
topic |
Medicina clínica Clinical medicine |
description |
The aim of the present work was to present the clinical outcomes of 76 azoospermic patients with non-mosaic Klinefelter syndrome, treated by testicular sperm extraction (TESE) followed by intracytoplasmic sperm injection (ICSI), using either fresh or cryopreserved testicular spermatozoa. Spermatozoa were recovered in 31/77 (40.3%) of the TESE attempts. The mean male age was 34.1 years old. In most of the cases, the testicular volume was reduced (96.1%), the levels of FSH (98.3%) and LH (94.1%) were increased, and the levels of testosterone were normal (77.6%). There were 25 ICSI treatment cycles using fresh testicular spermatozoa and 22 ICSI treatment cycles using frozen testicular spermatozoa. The rates of fertilization (63.5% vs 41.6%), implantation (37% vs 13.2%), clinical pregnancy (60.9% vs 19%), live birth delivery (52.2% vs 19%) and newborn (65.2% vs 23.8%) were higher in the group using fresh testicular spermatozoa. Chromosome analysis of the 21 newborns was normal. In conclusion, the present data adds further information regarding the recovery rate of spermatozoa after TESE and the embryological and clinical outcomes, besides reassuring the safety concerning to abnormal chromosomal transmission to the children of Klinefelter fathers. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-24 2021-05-24T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/139708 TID:203178882 |
url |
https://hdl.handle.net/10216/139708 |
identifier_str_mv |
TID:203178882 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
_version_ |
1817547485780901888 |