The biotechnological and seafood potential of Stichopus regalis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.8/6086 |
Resumo: | Sea cucumbers are highly used not only for the production of the bêche-de-mer, but also recent studies have been showing the high potential of these marine invertebrates on the pharmaceutical industry, as they are rich in bioactive compounds with important functions. Stichopus regalis extracts (1 mg∙mL−1) were used in antioxidant, antimicrobial and antitumor assays. The lipid profile was also evaluated. No significant antioxidant activity was detected in both methanolic and dichloromethane extracts. The methanolic fraction showed the highest antimicrobial potential against Candida albicans with an IC50 of 475.4 μg∙mL−1. In the antitumor assays, the dichloromethane fraction showed a high potential for both cell lines, as revealed by the MTT method. The total fat content was 3.63% ± 0.11% and the fatty acid profile revealed the highest amount in C16:0 (9.43% ± 0.77%), C18:0 (12.43% ± 0.83%), C18:1 ω7 (5.63% ± 0.33%), EPA (12.49% ± 0.15%), DHA (7.35% ± 0.02%), ARA (19.29% ± 0.14%) and a ω3/ω6 ratio of 1.078. These findings led us to suggest the potential use of S. regalis as a new source of bioactive compounds with pharmacological potential and its nutritional benefits for human health. |
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The biotechnological and seafood potential of Stichopus regalisSea cucumberAntimicrobial activityMarine natural compoundsFatty acid profileSea cucumbers are highly used not only for the production of the bêche-de-mer, but also recent studies have been showing the high potential of these marine invertebrates on the pharmaceutical industry, as they are rich in bioactive compounds with important functions. Stichopus regalis extracts (1 mg∙mL−1) were used in antioxidant, antimicrobial and antitumor assays. The lipid profile was also evaluated. No significant antioxidant activity was detected in both methanolic and dichloromethane extracts. The methanolic fraction showed the highest antimicrobial potential against Candida albicans with an IC50 of 475.4 μg∙mL−1. In the antitumor assays, the dichloromethane fraction showed a high potential for both cell lines, as revealed by the MTT method. The total fat content was 3.63% ± 0.11% and the fatty acid profile revealed the highest amount in C16:0 (9.43% ± 0.77%), C18:0 (12.43% ± 0.83%), C18:1 ω7 (5.63% ± 0.33%), EPA (12.49% ± 0.15%), DHA (7.35% ± 0.02%), ARA (19.29% ± 0.14%) and a ω3/ω6 ratio of 1.078. These findings led us to suggest the potential use of S. regalis as a new source of bioactive compounds with pharmacological potential and its nutritional benefits for human health.Scientific Research PublishingIC-OnlineSantos, RitaDias, SimauraPinteus, SuseteSilva, JoanaAlves, CelsoTecelão, CarlaPombo, AnaPedrosa, Rui2021-08-12T13:05:16Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/6086engSantos, R., Dias, S., Pinteus, S., Silva, J., Alves, C., Tecelão, C., Pombo, A. and Pedrosa, R. (2015) The Biotechnological and Seafood Potential of Stichopus regalis. Advances in Bioscience and Biotechnology, 6, 194-204. http://dx.doi.org/10.4236/abb.2015.630192156-850210.4236/abb.2015.63019info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:52:21Zoai:iconline.ipleiria.pt:10400.8/6086Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:49:25.094295Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The biotechnological and seafood potential of Stichopus regalis |
title |
The biotechnological and seafood potential of Stichopus regalis |
spellingShingle |
The biotechnological and seafood potential of Stichopus regalis Santos, Rita Sea cucumber Antimicrobial activity Marine natural compounds Fatty acid profile |
title_short |
The biotechnological and seafood potential of Stichopus regalis |
title_full |
The biotechnological and seafood potential of Stichopus regalis |
title_fullStr |
The biotechnological and seafood potential of Stichopus regalis |
title_full_unstemmed |
The biotechnological and seafood potential of Stichopus regalis |
title_sort |
The biotechnological and seafood potential of Stichopus regalis |
author |
Santos, Rita |
author_facet |
Santos, Rita Dias, Simaura Pinteus, Susete Silva, Joana Alves, Celso Tecelão, Carla Pombo, Ana Pedrosa, Rui |
author_role |
author |
author2 |
Dias, Simaura Pinteus, Susete Silva, Joana Alves, Celso Tecelão, Carla Pombo, Ana Pedrosa, Rui |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
IC-Online |
dc.contributor.author.fl_str_mv |
Santos, Rita Dias, Simaura Pinteus, Susete Silva, Joana Alves, Celso Tecelão, Carla Pombo, Ana Pedrosa, Rui |
dc.subject.por.fl_str_mv |
Sea cucumber Antimicrobial activity Marine natural compounds Fatty acid profile |
topic |
Sea cucumber Antimicrobial activity Marine natural compounds Fatty acid profile |
description |
Sea cucumbers are highly used not only for the production of the bêche-de-mer, but also recent studies have been showing the high potential of these marine invertebrates on the pharmaceutical industry, as they are rich in bioactive compounds with important functions. Stichopus regalis extracts (1 mg∙mL−1) were used in antioxidant, antimicrobial and antitumor assays. The lipid profile was also evaluated. No significant antioxidant activity was detected in both methanolic and dichloromethane extracts. The methanolic fraction showed the highest antimicrobial potential against Candida albicans with an IC50 of 475.4 μg∙mL−1. In the antitumor assays, the dichloromethane fraction showed a high potential for both cell lines, as revealed by the MTT method. The total fat content was 3.63% ± 0.11% and the fatty acid profile revealed the highest amount in C16:0 (9.43% ± 0.77%), C18:0 (12.43% ± 0.83%), C18:1 ω7 (5.63% ± 0.33%), EPA (12.49% ± 0.15%), DHA (7.35% ± 0.02%), ARA (19.29% ± 0.14%) and a ω3/ω6 ratio of 1.078. These findings led us to suggest the potential use of S. regalis as a new source of bioactive compounds with pharmacological potential and its nutritional benefits for human health. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z 2021-08-12T13:05:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.8/6086 |
url |
http://hdl.handle.net/10400.8/6086 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Santos, R., Dias, S., Pinteus, S., Silva, J., Alves, C., Tecelão, C., Pombo, A. and Pedrosa, R. (2015) The Biotechnological and Seafood Potential of Stichopus regalis. Advances in Bioscience and Biotechnology, 6, 194-204. http://dx.doi.org/10.4236/abb.2015.63019 2156-8502 10.4236/abb.2015.63019 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Scientific Research Publishing |
publisher.none.fl_str_mv |
Scientific Research Publishing |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136986634649600 |