The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A Systematic Review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/95713 https://doi.org/10.3389/fonc.2021.704664 |
Resumo: | In the last years, extensive investigation on miRNomics have shown to have great advantages in cancer personalized medicine regarding diagnosis, treatment and even clinical outcomes. Prostate cancer (PCa) is the second most common male cancer and about 50% of all PCa patients received radiotherapy (RT), despite some of them develop radioresistance. Here, we aim to provide an overview on the mechanisms of miRNA biogenesis and to discuss the functional impact of miRNAs on PCa under radiation response. As main findings, 23 miRNAs were already identified as being involved in genetic regulation of PCa cell response to RT. The mechanisms of radioresistance are still poorly understood, despite it has been suggested that miRNAs play an important role in cell signaling pathways. Identification of miRNAs panel can be thus considered an upcoming and potentially useful strategy in PCa diagnosis, given that radioresistance biomarkers, in both prognosis and therapy still remains a challenge. |
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The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A Systematic ReviewRNA therapy; microRNA; oncomiR; oncosupressor miR; prostate cancer; radiotherapyIn the last years, extensive investigation on miRNomics have shown to have great advantages in cancer personalized medicine regarding diagnosis, treatment and even clinical outcomes. Prostate cancer (PCa) is the second most common male cancer and about 50% of all PCa patients received radiotherapy (RT), despite some of them develop radioresistance. Here, we aim to provide an overview on the mechanisms of miRNA biogenesis and to discuss the functional impact of miRNAs on PCa under radiation response. As main findings, 23 miRNAs were already identified as being involved in genetic regulation of PCa cell response to RT. The mechanisms of radioresistance are still poorly understood, despite it has been suggested that miRNAs play an important role in cell signaling pathways. Identification of miRNAs panel can be thus considered an upcoming and potentially useful strategy in PCa diagnosis, given that radioresistance biomarkers, in both prognosis and therapy still remains a challenge.2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/95713http://hdl.handle.net/10316/95713https://doi.org/10.3389/fonc.2021.704664eng2234-943XSoares, SílviaGuerreiro, Susana GCruz-Martins, NatáliaFaria, IsabelBaylina, PilarSales, Maria GoretiCorrea-Duarte, Miguel AFernandes, Rúbeninfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T03:29:32Zoai:estudogeral.uc.pt:10316/95713Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:14:08.070993Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A Systematic Review |
title |
The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A Systematic Review |
spellingShingle |
The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A Systematic Review Soares, Sílvia RNA therapy; microRNA; oncomiR; oncosupressor miR; prostate cancer; radiotherapy |
title_short |
The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A Systematic Review |
title_full |
The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A Systematic Review |
title_fullStr |
The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A Systematic Review |
title_full_unstemmed |
The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A Systematic Review |
title_sort |
The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A Systematic Review |
author |
Soares, Sílvia |
author_facet |
Soares, Sílvia Guerreiro, Susana G Cruz-Martins, Natália Faria, Isabel Baylina, Pilar Sales, Maria Goreti Correa-Duarte, Miguel A Fernandes, Rúben |
author_role |
author |
author2 |
Guerreiro, Susana G Cruz-Martins, Natália Faria, Isabel Baylina, Pilar Sales, Maria Goreti Correa-Duarte, Miguel A Fernandes, Rúben |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Soares, Sílvia Guerreiro, Susana G Cruz-Martins, Natália Faria, Isabel Baylina, Pilar Sales, Maria Goreti Correa-Duarte, Miguel A Fernandes, Rúben |
dc.subject.por.fl_str_mv |
RNA therapy; microRNA; oncomiR; oncosupressor miR; prostate cancer; radiotherapy |
topic |
RNA therapy; microRNA; oncomiR; oncosupressor miR; prostate cancer; radiotherapy |
description |
In the last years, extensive investigation on miRNomics have shown to have great advantages in cancer personalized medicine regarding diagnosis, treatment and even clinical outcomes. Prostate cancer (PCa) is the second most common male cancer and about 50% of all PCa patients received radiotherapy (RT), despite some of them develop radioresistance. Here, we aim to provide an overview on the mechanisms of miRNA biogenesis and to discuss the functional impact of miRNAs on PCa under radiation response. As main findings, 23 miRNAs were already identified as being involved in genetic regulation of PCa cell response to RT. The mechanisms of radioresistance are still poorly understood, despite it has been suggested that miRNAs play an important role in cell signaling pathways. Identification of miRNAs panel can be thus considered an upcoming and potentially useful strategy in PCa diagnosis, given that radioresistance biomarkers, in both prognosis and therapy still remains a challenge. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/95713 http://hdl.handle.net/10316/95713 https://doi.org/10.3389/fonc.2021.704664 |
url |
http://hdl.handle.net/10316/95713 https://doi.org/10.3389/fonc.2021.704664 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2234-943X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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