Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/114755 |
Resumo: | POCI-01-0145-FEDER-007038 SFRH/BPD72891/2010 UMINHO/BI/248/2016 NORTE-01-0145-FEDER-000013 |
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Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s DiseaseBehavioral testsMPTPNeuroinflammationParkinson’s diseaseTUDCANeuroscience (miscellaneous)NeurologyCellular and Molecular NeuroscienceSDG 3 - Good Health and Well-beingPOCI-01-0145-FEDER-007038 SFRH/BPD72891/2010 UMINHO/BI/248/2016 NORTE-01-0145-FEDER-000013Parkinson’s disease (PD) is characterized by severe motor symptoms, and currently there is no treatment that retards disease progression or reverses damage prior to the time of clinical diagnosis. Tauroursodeoxycholic acid (TUDCA) is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD; however, its effect in PD motor symptoms has never been addressed. In the present work, an extensive behavior analysis was performed to better characterize the MPTP model of PD and to evaluate the effects of TUDCA in the prevention/improvement of mice phenotype. MPTP induced significant alterations in general motor performance paradigms, including increased latency in the motor swimming, adhesive removal and pole tests, as well as altered gait, foot dragging, and tremors. TUDCA administration, either before or after MPTP, significantly reduced the swimming latency, improved gait quality, and decreased foot dragging. Importantly, TUDCA was also effective in the prevention of typical parkinsonian symptoms such as spontaneous activity, ability to initiate movement and tremors. Accordingly, TUDCA prevented MPTP-induced decrease of dopaminergic fibers and ATP levels, mitochondrial dysfunction and neuroinflammation. Overall, MPTP-injected mice presented motor symptoms that are aggravated throughout time, resembling human parkinsonism, whereas PD motor symptoms were absent or mild in TUDCA-treated animals, and no aggravation was observed in any parameter. The thorough demonstration of improvement of PD symptoms together with the demonstration of the pathways triggered by TUDCA supports a subsequent clinical trial in humans and future validation of the application of this bile acid in PD.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitRUNRosa, Alexandra IsabelDuarte-Silva, SaraSilva-Fernandes, AnabelaNunes, Maria JoãoCarvalho, Andreia NevesRodrigues, ElsaGama, Maria JoãoRodrigues, Cecília Maria PereiraMaciel, PatríciaCastro-Caldas, Margarida2021-03-30T22:17:18Z2018-12-012018-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/114755eng0893-7648PURE: 12439030https://doi.org/10.1007/s12035-018-1062-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:57:31Zoai:run.unl.pt:10362/114755Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:42:37.706658Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease |
| title |
Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease |
| spellingShingle |
Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease Rosa, Alexandra Isabel Behavioral tests MPTP Neuroinflammation Parkinson’s disease TUDCA Neuroscience (miscellaneous) Neurology Cellular and Molecular Neuroscience SDG 3 - Good Health and Well-being |
| title_short |
Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease |
| title_full |
Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease |
| title_fullStr |
Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease |
| title_full_unstemmed |
Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease |
| title_sort |
Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease |
| author |
Rosa, Alexandra Isabel |
| author_facet |
Rosa, Alexandra Isabel Duarte-Silva, Sara Silva-Fernandes, Anabela Nunes, Maria João Carvalho, Andreia Neves Rodrigues, Elsa Gama, Maria João Rodrigues, Cecília Maria Pereira Maciel, Patrícia Castro-Caldas, Margarida |
| author_role |
author |
| author2 |
Duarte-Silva, Sara Silva-Fernandes, Anabela Nunes, Maria João Carvalho, Andreia Neves Rodrigues, Elsa Gama, Maria João Rodrigues, Cecília Maria Pereira Maciel, Patrícia Castro-Caldas, Margarida |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
DCV - Departamento de Ciências da Vida UCIBIO - Applied Molecular Biosciences Unit RUN |
| dc.contributor.author.fl_str_mv |
Rosa, Alexandra Isabel Duarte-Silva, Sara Silva-Fernandes, Anabela Nunes, Maria João Carvalho, Andreia Neves Rodrigues, Elsa Gama, Maria João Rodrigues, Cecília Maria Pereira Maciel, Patrícia Castro-Caldas, Margarida |
| dc.subject.por.fl_str_mv |
Behavioral tests MPTP Neuroinflammation Parkinson’s disease TUDCA Neuroscience (miscellaneous) Neurology Cellular and Molecular Neuroscience SDG 3 - Good Health and Well-being |
| topic |
Behavioral tests MPTP Neuroinflammation Parkinson’s disease TUDCA Neuroscience (miscellaneous) Neurology Cellular and Molecular Neuroscience SDG 3 - Good Health and Well-being |
| description |
POCI-01-0145-FEDER-007038 SFRH/BPD72891/2010 UMINHO/BI/248/2016 NORTE-01-0145-FEDER-000013 |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-12-01 2018-12-01T00:00:00Z 2021-03-30T22:17:18Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/114755 |
| url |
http://hdl.handle.net/10362/114755 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0893-7648 PURE: 12439030 https://doi.org/10.1007/s12035-018-1062-4 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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17 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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