Organizing pneumonia and COVID-19 : a report of two cases
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/46250 |
Resumo: | © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. |
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Organizing pneumonia and COVID-19 : a report of two casesElsevierCOVID-19SARS-CoV-2CoronavirusOrganizing pneumoniaCorticosteroidsPortugal© 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.Organizing pneumonia (OP) is a sub-acute process of pulmonary tissue repair secondary to lung injury, defined histopathologically by intra-alveolar buds of granulation tissue within the lumen of distal pulmonary airspaces. It can be either cryptogenic or secondary (SOP) to different clinical conditions, namely infections. Despite being nonspecific, its diagnosis can be made by the association of clinical and imaging criteria. We report two cases of OP associated to SARS-CoV-2 pneumonia, admitted at a Portuguese tertiary hospital unit dedicated to COVID-19. Both patients presented with severe respiratory failure with need of invasive mechanical ventilation. After initial recovery, there was worsening of dyspnea and hypoxemic respiratory failure with increase in inflammatory markers. Chest CT revealed an OP pattern. Other conditions such as superinfection, auto-immune disease and iatrogenic etiology, were excluded and corticotherapy at a dose of 1 mg/kg/day was administered. Chest CT follow up of both our patients showed complete resolution of OP pattern, with mild to moderate residual pulmonary fibrosis without honeycombing. There is no OP to SARS-CoV-2 case series yet published describing the progress of patients after corticotherapy, although the association between systemic corticosteroids and lower all-cause mortality in patients with COVID-19 has been recently established. It is possible that, as has been described with other viruses, OP secondary to SARS-CoV-2 represents an immunological process after initial infection, presenting with elevation of inflammatory markers and cytokines storm in the bloodstream and lung tissue, which may explain the favorable response to corticosteroids.ElsevierRepositório da Universidade de LisboaSimões, Joana PaivaAlves Ferreira, Ana RitaAlmeida, Pedro MartinsTrigueiros, FredericoBraz, ArmandoInácio, João RodriguesMedeiros, FábioBraz, SandraPais de Lacerda, António2021-02-09T17:05:55Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46250engRespir Med Case Rep. 2021;32:10135910.1016/j.rmcr.2021.1013592213-0071info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:48:27Zoai:repositorio.ul.pt:10451/46250Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:29.138411Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Organizing pneumonia and COVID-19 : a report of two cases Elsevier |
| title |
Organizing pneumonia and COVID-19 : a report of two cases |
| spellingShingle |
Organizing pneumonia and COVID-19 : a report of two cases Simões, Joana Paiva COVID-19 SARS-CoV-2 Coronavirus Organizing pneumonia Corticosteroids Portugal |
| title_short |
Organizing pneumonia and COVID-19 : a report of two cases |
| title_full |
Organizing pneumonia and COVID-19 : a report of two cases |
| title_fullStr |
Organizing pneumonia and COVID-19 : a report of two cases |
| title_full_unstemmed |
Organizing pneumonia and COVID-19 : a report of two cases |
| title_sort |
Organizing pneumonia and COVID-19 : a report of two cases |
| author |
Simões, Joana Paiva |
| author_facet |
Simões, Joana Paiva Alves Ferreira, Ana Rita Almeida, Pedro Martins Trigueiros, Frederico Braz, Armando Inácio, João Rodrigues Medeiros, Fábio Braz, Sandra Pais de Lacerda, António |
| author_role |
author |
| author2 |
Alves Ferreira, Ana Rita Almeida, Pedro Martins Trigueiros, Frederico Braz, Armando Inácio, João Rodrigues Medeiros, Fábio Braz, Sandra Pais de Lacerda, António |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Simões, Joana Paiva Alves Ferreira, Ana Rita Almeida, Pedro Martins Trigueiros, Frederico Braz, Armando Inácio, João Rodrigues Medeiros, Fábio Braz, Sandra Pais de Lacerda, António |
| dc.subject.por.fl_str_mv |
COVID-19 SARS-CoV-2 Coronavirus Organizing pneumonia Corticosteroids Portugal |
| topic |
COVID-19 SARS-CoV-2 Coronavirus Organizing pneumonia Corticosteroids Portugal |
| description |
© 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-02-09T17:05:55Z 2021 2021-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/46250 |
| url |
http://hdl.handle.net/10451/46250 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Respir Med Case Rep. 2021;32:101359 10.1016/j.rmcr.2021.101359 2213-0071 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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