Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/134572 |
Resumo: | Funding: This study was endorsed by the ESICM. Free support for running the electronic database was granted from the Department of Epidemiology, Aarhus University, Denmark. The support of the study in France by a grant from ‘Fondation Assistance Publique-Hôpitaux de Paris pour la recherche’ is greatly appreciated. In Norway, the study was supported by a grant from the Health Region West. In addition, the study was supported by a grant from the European Open Science Cloud (EOSC). EOSCsecretariat.eu has received funding from the European Union’s Horizon 2020 Framework Programme called H2020-INFRAEOSC-05-2018-2019, Grant Agreement Number 831644. This work was supported by the Forschungskommission of the Medical Faculty of the Heinrich Heine University Düsseldorf, No. 2018-32 to G.W. and No. 2020-21 to R.R.B. for a Clinician Scientist Track. Open access funding was enabled and organized by Projekt DEAL. No (industry) sponsorship has been received for this investigator-initiated study. |
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7160 |
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Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19Funding: This study was endorsed by the ESICM. Free support for running the electronic database was granted from the Department of Epidemiology, Aarhus University, Denmark. The support of the study in France by a grant from ‘Fondation Assistance Publique-Hôpitaux de Paris pour la recherche’ is greatly appreciated. In Norway, the study was supported by a grant from the Health Region West. In addition, the study was supported by a grant from the European Open Science Cloud (EOSC). EOSCsecretariat.eu has received funding from the European Union’s Horizon 2020 Framework Programme called H2020-INFRAEOSC-05-2018-2019, Grant Agreement Number 831644. This work was supported by the Forschungskommission of the Medical Faculty of the Heinrich Heine University Düsseldorf, No. 2018-32 to G.W. and No. 2020-21 to R.R.B. for a Clinician Scientist Track. Open access funding was enabled and organized by Projekt DEAL. No (industry) sponsorship has been received for this investigator-initiated study.AIMS: Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID-19). This prospective international multicentre study investigates the role of pre-existing CHF on clinical outcomes of critically ill old (≥70 years) intensive care patients with COVID-19. METHODS AND RESULTS: Patients with pre-existing CHF were subclassified as having ischaemic or non-ischaemic cardiac disease; patients with a documented ejection fraction (EF) were subclassified according to heart failure EF: reduced (HFrEF, n = 132), mild (HFmrEF, n = 91), or preserved (HFpEF, n = 103). Associations of heart failure characteristics with the 30 day mortality were analysed in univariate and multivariate logistic regression analyses. Pre-existing CHF was reported in 566 of 3917 patients (14%). Patients with CHF were older, frailer, and had significantly higher SOFA scores on admission. CHF patients showed significantly higher crude 30 day mortality [60% vs. 48%, P < 0.001; odds ratio 1.87, 95% confidence interval (CI) 1.5-2.3] and 3 month mortality (69% vs. 56%, P < 0.001). After multivariate adjustment for confounders (SOFA, age, sex, and frailty), no independent association of CHF with mortality remained [adjusted odds ratio (aOR) 1.2, 95% CI 0.5-1.5; P = 0.137]. More patients suffered from pre-existing ischaemic than from non-ischaemic disease [233 vs. 328 patients (n = 5 unknown aetiology)]. There were no differences in baseline characteristics between ischaemic and non-ischaemic disease or between HFrEF, HFmrEF, and HFpEF. Crude 30 day mortality was significantly higher in HFrEF compared with HFpEF (64% vs. 48%, P = 0.042). EF as a continuous variable was not independently associated with 30 day mortality (aOR 0.98, 95% CI 0.9-1.0; P = 0.128). CONCLUSIONS: In critically ill older COVID-19 patients, pre-existing CHF was not independently associated with 30 day mortality. TRIAL REGISTRATION NUMBER: NCT04321265.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBruno, Raphael RomanoWernly, BernhardWolff, GeorgFjølner, JesperArtigas, AntonioBollen Pinto, BernardoSchefold, Joerg CKindgen-Milles, DetlefBaldia, Philipp HeinrichKelm, MalteBeil, MichaelSviri, Sigalvan Heerden, Peter VernonSzczeklik, WojciechTopeli, ArzuElhadi, MuhammedJoannidis, MichaelOeyen, SandraKondili, EumorfiaMarsh, BrianAndersen, Finn HMoreno, RuiLeaver, SusannahBoumendil, ArianeDe Lange, Dylan WGuidet, BertrandFlaatten, HansJung, Christian2022-03-15T23:23:10Z2022-062022-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/134572eng2055-5822PURE: 42383434https://doi.org/10.1002/ehf2.13854info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:00:12Zoai:run.unl.pt:10362/134572Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:00:12Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 |
title |
Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 |
spellingShingle |
Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 Bruno, Raphael Romano |
title_short |
Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 |
title_full |
Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 |
title_fullStr |
Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 |
title_full_unstemmed |
Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 |
title_sort |
Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 |
author |
Bruno, Raphael Romano |
author_facet |
Bruno, Raphael Romano Wernly, Bernhard Wolff, Georg Fjølner, Jesper Artigas, Antonio Bollen Pinto, Bernardo Schefold, Joerg C Kindgen-Milles, Detlef Baldia, Philipp Heinrich Kelm, Malte Beil, Michael Sviri, Sigal van Heerden, Peter Vernon Szczeklik, Wojciech Topeli, Arzu Elhadi, Muhammed Joannidis, Michael Oeyen, Sandra Kondili, Eumorfia Marsh, Brian Andersen, Finn H Moreno, Rui Leaver, Susannah Boumendil, Ariane De Lange, Dylan W Guidet, Bertrand Flaatten, Hans Jung, Christian |
author_role |
author |
author2 |
Wernly, Bernhard Wolff, Georg Fjølner, Jesper Artigas, Antonio Bollen Pinto, Bernardo Schefold, Joerg C Kindgen-Milles, Detlef Baldia, Philipp Heinrich Kelm, Malte Beil, Michael Sviri, Sigal van Heerden, Peter Vernon Szczeklik, Wojciech Topeli, Arzu Elhadi, Muhammed Joannidis, Michael Oeyen, Sandra Kondili, Eumorfia Marsh, Brian Andersen, Finn H Moreno, Rui Leaver, Susannah Boumendil, Ariane De Lange, Dylan W Guidet, Bertrand Flaatten, Hans Jung, Christian |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Bruno, Raphael Romano Wernly, Bernhard Wolff, Georg Fjølner, Jesper Artigas, Antonio Bollen Pinto, Bernardo Schefold, Joerg C Kindgen-Milles, Detlef Baldia, Philipp Heinrich Kelm, Malte Beil, Michael Sviri, Sigal van Heerden, Peter Vernon Szczeklik, Wojciech Topeli, Arzu Elhadi, Muhammed Joannidis, Michael Oeyen, Sandra Kondili, Eumorfia Marsh, Brian Andersen, Finn H Moreno, Rui Leaver, Susannah Boumendil, Ariane De Lange, Dylan W Guidet, Bertrand Flaatten, Hans Jung, Christian |
description |
Funding: This study was endorsed by the ESICM. Free support for running the electronic database was granted from the Department of Epidemiology, Aarhus University, Denmark. The support of the study in France by a grant from ‘Fondation Assistance Publique-Hôpitaux de Paris pour la recherche’ is greatly appreciated. In Norway, the study was supported by a grant from the Health Region West. In addition, the study was supported by a grant from the European Open Science Cloud (EOSC). EOSCsecretariat.eu has received funding from the European Union’s Horizon 2020 Framework Programme called H2020-INFRAEOSC-05-2018-2019, Grant Agreement Number 831644. This work was supported by the Forschungskommission of the Medical Faculty of the Heinrich Heine University Düsseldorf, No. 2018-32 to G.W. and No. 2020-21 to R.R.B. for a Clinician Scientist Track. Open access funding was enabled and organized by Projekt DEAL. No (industry) sponsorship has been received for this investigator-initiated study. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-15T23:23:10Z 2022-06 2022-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/134572 |
url |
http://hdl.handle.net/10362/134572 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2055-5822 PURE: 42383434 https://doi.org/10.1002/ehf2.13854 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545851578351616 |