Gla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKD

Detalhes bibliográficos
Autor(a) principal: Silva, Ana P.
Data de Publicação: 2022
Outros Autores: Viegas, Carla S. B., Guilherme, Patrícia, Tavares, Nelson, Dias, Carolina, Rato, Fátima, Santos, Nélio, Faísca, Marília, Almeida, Edgar, Neves, Pedro L., Simes, Dina C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/53477
Resumo: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Gla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKDGla-rich proteinCardiovascular calcificationCardiovascular diseaseCardiovascular risk assessmentChronic kidney diseaseValvular calcificationVascular calcification© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Accelerated and premature cardiovascular calcification is a hallmark of chronic kidney disease (CKD) patients. Valvular calcification (VC) is a critical indicator of cardiovascular disease and all-cause mortality in this population, lacking validated biomarkers for early diagnosis. Gla-rich protein (GRP) is a cardiovascular calcification inhibitor recently associated with vascular calcification, pulse pressure, mineral metabolism markers and kidney function. Here, we examined the association between GRP serum levels and mitral and aortic valves calcification in a cohort of 80 diabetic patients with CKD stages 2-4. Mitral and aortic valves calcification were detected in 36.2% and 34.4% of the patients and associated with lower GRP levels, even after adjustments for age and gender. In this pilot study, univariate, multivariate and Poisson regression analysis, show that low levels of GRP and magnesium (Mg), and high levels of phosphate (P) are associated with mitral and aortic valves calcification. Receiver operating characteristic (ROC) curves showed that the area under the curve (AUC) values of GRP for mitral (0.762) and aortic (0.802) valves calcification were higher than those of Mg and P. These results suggest that low levels of GRP and Mg, and high levels of P, are independent and cumulative risk factors for VC in this population; the GRP diagnostic value might be potentially useful in cardiovascular risk assessment.This research was funded by the Portuguese Society of Nephrology (SPN) through projects funding 2017 and 2019; by the Portuguese National Funds from FCT—Foundation for Science and Technology, through the transitional provision DL57/2016/CP1361/CT0006, and projects EXPL/BTM-TEC/0990/2021 and UIDB/04326/2020; and by AAC nº 41/ALG/2020—Project nº 072583—NUTRISAFE.MDPIRepositório da Universidade de LisboaSilva, Ana P.Viegas, Carla S. B.Guilherme, PatríciaTavares, NelsonDias, CarolinaRato, FátimaSantos, NélioFaísca, MaríliaAlmeida, EdgarNeves, Pedro L.Simes, Dina C.2022-06-24T11:29:46Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/53477engDiagnostics (Basel). 2022 Feb 15;12(2):49610.3390/diagnostics120204962075-4418info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:59:15Zoai:repositorio.ul.pt:10451/53477Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:04:24.724013Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKD
title Gla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKD
spellingShingle Gla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKD
Silva, Ana P.
Gla-rich protein
Cardiovascular calcification
Cardiovascular disease
Cardiovascular risk assessment
Chronic kidney disease
Valvular calcification
Vascular calcification
title_short Gla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKD
title_full Gla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKD
title_fullStr Gla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKD
title_full_unstemmed Gla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKD
title_sort Gla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKD
author Silva, Ana P.
author_facet Silva, Ana P.
Viegas, Carla S. B.
Guilherme, Patrícia
Tavares, Nelson
Dias, Carolina
Rato, Fátima
Santos, Nélio
Faísca, Marília
Almeida, Edgar
Neves, Pedro L.
Simes, Dina C.
author_role author
author2 Viegas, Carla S. B.
Guilherme, Patrícia
Tavares, Nelson
Dias, Carolina
Rato, Fátima
Santos, Nélio
Faísca, Marília
Almeida, Edgar
Neves, Pedro L.
Simes, Dina C.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva, Ana P.
Viegas, Carla S. B.
Guilherme, Patrícia
Tavares, Nelson
Dias, Carolina
Rato, Fátima
Santos, Nélio
Faísca, Marília
Almeida, Edgar
Neves, Pedro L.
Simes, Dina C.
dc.subject.por.fl_str_mv Gla-rich protein
Cardiovascular calcification
Cardiovascular disease
Cardiovascular risk assessment
Chronic kidney disease
Valvular calcification
Vascular calcification
topic Gla-rich protein
Cardiovascular calcification
Cardiovascular disease
Cardiovascular risk assessment
Chronic kidney disease
Valvular calcification
Vascular calcification
description © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2022
dc.date.none.fl_str_mv 2022-06-24T11:29:46Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/53477
url http://hdl.handle.net/10451/53477
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Diagnostics (Basel). 2022 Feb 15;12(2):496
10.3390/diagnostics12020496
2075-4418
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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