Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa

Detalhes bibliográficos
Autor(a) principal: Trovoada, Maria Jesus
Data de Publicação: 2014
Outros Autores: Gonçalves, Lígia A., Marinho, Cláudio R. F., Turner, Louise, Hviid, Lars, Penha-Gonçalves, Carlos, Gomes, M. Gabriela M.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/317
Resumo: This deposit is composed by the main article plus the supplementary materials of the publication.
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spelling Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West AfricaMalaria InfectionImmunityThis deposit is composed by the main article plus the supplementary materials of the publication.After remarkable success of vector control campaigns worldwide, concerns about loss of immunity against Plasmodium falciparum due to lack of exposure to the parasite are relevant since an increase of severe cases in less immune individuals is expected. We present a mathematical model to investigate the impact of reducing exposure to the parasite on the immune repertoire against P. falciparum erythrocyte membrane protein 1 (PfEMP1) variants. The model was parameterized with data from Príncipe Island, West Africa, and applied to simulate two alternative transmission scenarios: one where control measures are continued to eventually drive the system to elimination; and another where the effort is interrupted after 6 years of its initiation and the system returns to the initial transmission potential. Population dynamics of parasite prevalence predict that in a few years infection levels return to the pre-control values, while the re-acquisition of the immune repertoire against PfEMP1 is slower, creating a window for increased severity. The model illustrates the consequences of loss of immune repertoire against PfEMP1 in a given setting and can be applied to other regions where similar data may be available.Portuguese Foundation for Science and Technology (FCT).PLOSARCATrovoada, Maria JesusGonçalves, Lígia A.Marinho, Cláudio R. F.Turner, LouiseHviid, LarsPenha-Gonçalves, CarlosGomes, M. Gabriela M.2015-09-23T16:45:14Z2014-02-102014-02-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfimage/tiffimage/tiffimage/tiffapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.7/317porBandeiras C, Trovoada MJ, Gonçalves LA, Marinho CRF, Turner L, Hviid L, et al. (2014) Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa. PLoS ONE 9(2): e88110. doi:10.1371/journal.pone.008811010.1371/journal.pone.0088110info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:43Zoai:arca.igc.gulbenkian.pt:10400.7/317Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:38.168167Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa
title Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa
spellingShingle Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa
Trovoada, Maria Jesus
Malaria Infection
Immunity
title_short Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa
title_full Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa
title_fullStr Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa
title_full_unstemmed Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa
title_sort Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa
author Trovoada, Maria Jesus
author_facet Trovoada, Maria Jesus
Gonçalves, Lígia A.
Marinho, Cláudio R. F.
Turner, Louise
Hviid, Lars
Penha-Gonçalves, Carlos
Gomes, M. Gabriela M.
author_role author
author2 Gonçalves, Lígia A.
Marinho, Cláudio R. F.
Turner, Louise
Hviid, Lars
Penha-Gonçalves, Carlos
Gomes, M. Gabriela M.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Trovoada, Maria Jesus
Gonçalves, Lígia A.
Marinho, Cláudio R. F.
Turner, Louise
Hviid, Lars
Penha-Gonçalves, Carlos
Gomes, M. Gabriela M.
dc.subject.por.fl_str_mv Malaria Infection
Immunity
topic Malaria Infection
Immunity
description This deposit is composed by the main article plus the supplementary materials of the publication.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-10
2014-02-10T00:00:00Z
2015-09-23T16:45:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/317
url http://hdl.handle.net/10400.7/317
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Bandeiras C, Trovoada MJ, Gonçalves LA, Marinho CRF, Turner L, Hviid L, et al. (2014) Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa. PLoS ONE 9(2): e88110. doi:10.1371/journal.pone.0088110
10.1371/journal.pone.0088110
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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