Opening the black-box of artificial intelligence predictions on clinical decision support systems

• Autor(a) principal: Neves, Maria Inês Lourenço das
• Data de Publicação: 2021
• Tipo de documento: Dissertação
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/126699
• topic: Machine learning; Time Series; Heartbeat Classifier; Explainable Artificial Intelligence; Model-Agnostic Method; Domínio/Área Científica::Engenharia e Tecnologia::Engenharia Médica

Cardiovascular diseases are the leading global death cause. Their treatment and prevention rely on electrocardiogram interpretation, which is dependent on the physician’s variability. Subjectiveness is intrinsic to electrocardiogram interpretation and hence, prone to errors. To assist physicians in making precise and thoughtful decisions, artificial intelligence is being deployed to develop models that can interpret extent datasets and provide accurate decisions. However, the lack of interpretability of most machine learning models stands as one of the drawbacks of their deployment, particularly in the medical domain. Furthermore, most of the currently deployed explainable artificial intelligence methods assume independence between features, which means temporal independence when dealing with time series. The inherent characteristic of time series cannot be ignored as it carries importance for the human decision making process. This dissertation focuses on the explanation of heartbeat classification using several adaptations of state-of-the-art model-agnostic methods, to locally explain time series classification. To address the explanation of time series classifiers, a preliminary conceptual framework is proposed, and the use of the derivative is suggested as a complement to add temporal dependency between samples. The results were validated on an extent public dataset, through the 1-D Jaccard’s index, which consists of the comparison of the subsequences extracted from an interpretable model and the explanation methods used. Secondly, through the performance’s decrease, to evaluate whether the explanation fits the model’s behaviour. To assess models with distinct internal logic, the validation was conducted on a more transparent model and more opaque one in both binary and multiclass situation. The results show the promising use of including the signal’s derivative to introduce temporal dependency between samples in the explanations, for models with simpler internal logic.