Assignment of novel functions to Helicobacter pylori 26695’s genome
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/32221 |
Resumo: | Helicobacter pylori is a pathogenic bacterium that colonizes the human epithelia, causing duodenal and gastric ulcers as well as gastric cancer. The genome of H. pylori 26695 has been sequenced and annotated. In addition, two genome-scale metabolic models have been developed. In order to maintain accurate and relevant information on coding sequences (CDS) and to retrieve new information, the assignment of new functions to Helicobacter pylori 26695’s genes was performed. The use of software tools, on-line databases and an annotation pipeline for inspecting each gene allowed the attribution of validated E.C. numbers to metabolic genes, and the assignment of 177 new functions to the CDS of this bacterium. This information provides relevant biological information for the scientific community dealing with this organism and can be used as the basis for a new metabolic model reconstruction. |
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Assignment of novel functions to Helicobacter pylori 26695’s genomeHelicobacter pyloriGenome annotationMetabolic functionsGenome-Scale ReconstructionHelicobacter pylori is a pathogenic bacterium that colonizes the human epithelia, causing duodenal and gastric ulcers as well as gastric cancer. The genome of H. pylori 26695 has been sequenced and annotated. In addition, two genome-scale metabolic models have been developed. In order to maintain accurate and relevant information on coding sequences (CDS) and to retrieve new information, the assignment of new functions to Helicobacter pylori 26695’s genes was performed. The use of software tools, on-line databases and an annotation pipeline for inspecting each gene allowed the attribution of validated E.C. numbers to metabolic genes, and the assignment of 177 new functions to the CDS of this bacterium. This information provides relevant biological information for the scientific community dealing with this organism and can be used as the basis for a new metabolic model reconstruction.(undefined)This work was supported by the project FCOMP-01-0124- FEDER-009707, entitled “HeliSysBio – molecular Systems Biology in Helicobac ter pylori” (Ref.: FCT PTDC/EBB-EBI/104235/2008). Daniela Correia is grateful for financial support from the FCT (PhD grant: SFRH/BD/47596/2008).SpringerUniversidade do MinhoResende, T.Correia, Daniela Matilde MarquesRocha, I.20132013-01-01T00:00:00Zbook partinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/1822/32221engResende, T., Correia, D.M., Rocha, I. (2013). Assignment of Novel Functions to Helicobacter pylori 26695’s Genome. In: Mohamad, M., Nanni, L., Rocha, M., Fdez-Riverola, F. (eds) 7th International Conference on Practical Applications of Computational Biology & Bioinformatics. Advances in Intelligent Systems and Computing, vol 222. Springer, Heidelberg. https://doi.org/10.1007/978-3-319-00578-2_597833190057752194-53572194-536510.1007/978-3-319-00578-2_5https://link.springer.com/chapter/10.1007/978-3-319-00578-2_5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-16T01:27:05Zoai:repositorium.sdum.uminho.pt:1822/32221Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-16T01:27:05Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Assignment of novel functions to Helicobacter pylori 26695’s genome |
title |
Assignment of novel functions to Helicobacter pylori 26695’s genome |
spellingShingle |
Assignment of novel functions to Helicobacter pylori 26695’s genome Resende, T. Helicobacter pylori Genome annotation Metabolic functions Genome-Scale Reconstruction |
title_short |
Assignment of novel functions to Helicobacter pylori 26695’s genome |
title_full |
Assignment of novel functions to Helicobacter pylori 26695’s genome |
title_fullStr |
Assignment of novel functions to Helicobacter pylori 26695’s genome |
title_full_unstemmed |
Assignment of novel functions to Helicobacter pylori 26695’s genome |
title_sort |
Assignment of novel functions to Helicobacter pylori 26695’s genome |
author |
Resende, T. |
author_facet |
Resende, T. Correia, Daniela Matilde Marques Rocha, I. |
author_role |
author |
author2 |
Correia, Daniela Matilde Marques Rocha, I. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Resende, T. Correia, Daniela Matilde Marques Rocha, I. |
dc.subject.por.fl_str_mv |
Helicobacter pylori Genome annotation Metabolic functions Genome-Scale Reconstruction |
topic |
Helicobacter pylori Genome annotation Metabolic functions Genome-Scale Reconstruction |
description |
Helicobacter pylori is a pathogenic bacterium that colonizes the human epithelia, causing duodenal and gastric ulcers as well as gastric cancer. The genome of H. pylori 26695 has been sequenced and annotated. In addition, two genome-scale metabolic models have been developed. In order to maintain accurate and relevant information on coding sequences (CDS) and to retrieve new information, the assignment of new functions to Helicobacter pylori 26695’s genes was performed. The use of software tools, on-line databases and an annotation pipeline for inspecting each gene allowed the attribution of validated E.C. numbers to metabolic genes, and the assignment of 177 new functions to the CDS of this bacterium. This information provides relevant biological information for the scientific community dealing with this organism and can be used as the basis for a new metabolic model reconstruction. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z |
dc.type.driver.fl_str_mv |
book part |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/32221 |
url |
https://hdl.handle.net/1822/32221 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Resende, T., Correia, D.M., Rocha, I. (2013). Assignment of Novel Functions to Helicobacter pylori 26695’s Genome. In: Mohamad, M., Nanni, L., Rocha, M., Fdez-Riverola, F. (eds) 7th International Conference on Practical Applications of Computational Biology & Bioinformatics. Advances in Intelligent Systems and Computing, vol 222. Springer, Heidelberg. https://doi.org/10.1007/978-3-319-00578-2_5 9783319005775 2194-5357 2194-5365 10.1007/978-3-319-00578-2_5 https://link.springer.com/chapter/10.1007/978-3-319-00578-2_5 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817544741522243584 |