Assignment of novel functions to Helicobacter pylori 26695’s genome

Detalhes bibliográficos
Autor(a) principal: Resende, T.
Data de Publicação: 2013
Outros Autores: Correia, Daniela Matilde Marques, Rocha, I.
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/32221
Resumo: Helicobacter pylori is a pathogenic bacterium that colonizes the human epithelia, causing duodenal and gastric ulcers as well as gastric cancer. The genome of H. pylori 26695 has been sequenced and annotated. In addition, two genome-scale metabolic models have been developed. In order to maintain accurate and relevant information on coding sequences (CDS) and to retrieve new information, the assignment of new functions to Helicobacter pylori 26695’s genes was performed. The use of software tools, on-line databases and an annotation pipeline for inspecting each gene allowed the attribution of validated E.C. numbers to metabolic genes, and the assignment of 177 new functions to the CDS of this bacterium. This information provides relevant biological information for the scientific community dealing with this organism and can be used as the basis for a new metabolic model reconstruction.
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spelling Assignment of novel functions to Helicobacter pylori 26695’s genomeHelicobacter pyloriGenome annotationMetabolic functionsGenome-Scale ReconstructionHelicobacter pylori is a pathogenic bacterium that colonizes the human epithelia, causing duodenal and gastric ulcers as well as gastric cancer. The genome of H. pylori 26695 has been sequenced and annotated. In addition, two genome-scale metabolic models have been developed. In order to maintain accurate and relevant information on coding sequences (CDS) and to retrieve new information, the assignment of new functions to Helicobacter pylori 26695’s genes was performed. The use of software tools, on-line databases and an annotation pipeline for inspecting each gene allowed the attribution of validated E.C. numbers to metabolic genes, and the assignment of 177 new functions to the CDS of this bacterium. This information provides relevant biological information for the scientific community dealing with this organism and can be used as the basis for a new metabolic model reconstruction.(undefined)This work was supported by the project FCOMP-01-0124- FEDER-009707, entitled “HeliSysBio – molecular Systems Biology in Helicobac ter pylori” (Ref.: FCT PTDC/EBB-EBI/104235/2008). Daniela Correia is grateful for financial support from the FCT (PhD grant: SFRH/BD/47596/2008).SpringerUniversidade do MinhoResende, T.Correia, Daniela Matilde MarquesRocha, I.20132013-01-01T00:00:00Zbook partinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/1822/32221engResende, T., Correia, D.M., Rocha, I. (2013). Assignment of Novel Functions to Helicobacter pylori 26695’s Genome. In: Mohamad, M., Nanni, L., Rocha, M., Fdez-Riverola, F. (eds) 7th International Conference on Practical Applications of Computational Biology & Bioinformatics. Advances in Intelligent Systems and Computing, vol 222. Springer, Heidelberg. https://doi.org/10.1007/978-3-319-00578-2_597833190057752194-53572194-536510.1007/978-3-319-00578-2_5https://link.springer.com/chapter/10.1007/978-3-319-00578-2_5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-16T01:27:05Zoai:repositorium.sdum.uminho.pt:1822/32221Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-16T01:27:05Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Assignment of novel functions to Helicobacter pylori 26695’s genome
title Assignment of novel functions to Helicobacter pylori 26695’s genome
spellingShingle Assignment of novel functions to Helicobacter pylori 26695’s genome
Resende, T.
Helicobacter pylori
Genome annotation
Metabolic functions
Genome-Scale Reconstruction
title_short Assignment of novel functions to Helicobacter pylori 26695’s genome
title_full Assignment of novel functions to Helicobacter pylori 26695’s genome
title_fullStr Assignment of novel functions to Helicobacter pylori 26695’s genome
title_full_unstemmed Assignment of novel functions to Helicobacter pylori 26695’s genome
title_sort Assignment of novel functions to Helicobacter pylori 26695’s genome
author Resende, T.
author_facet Resende, T.
Correia, Daniela Matilde Marques
Rocha, I.
author_role author
author2 Correia, Daniela Matilde Marques
Rocha, I.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Resende, T.
Correia, Daniela Matilde Marques
Rocha, I.
dc.subject.por.fl_str_mv Helicobacter pylori
Genome annotation
Metabolic functions
Genome-Scale Reconstruction
topic Helicobacter pylori
Genome annotation
Metabolic functions
Genome-Scale Reconstruction
description Helicobacter pylori is a pathogenic bacterium that colonizes the human epithelia, causing duodenal and gastric ulcers as well as gastric cancer. The genome of H. pylori 26695 has been sequenced and annotated. In addition, two genome-scale metabolic models have been developed. In order to maintain accurate and relevant information on coding sequences (CDS) and to retrieve new information, the assignment of new functions to Helicobacter pylori 26695’s genes was performed. The use of software tools, on-line databases and an annotation pipeline for inspecting each gene allowed the attribution of validated E.C. numbers to metabolic genes, and the assignment of 177 new functions to the CDS of this bacterium. This information provides relevant biological information for the scientific community dealing with this organism and can be used as the basis for a new metabolic model reconstruction.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.driver.fl_str_mv book part
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/32221
url https://hdl.handle.net/1822/32221
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Resende, T., Correia, D.M., Rocha, I. (2013). Assignment of Novel Functions to Helicobacter pylori 26695’s Genome. In: Mohamad, M., Nanni, L., Rocha, M., Fdez-Riverola, F. (eds) 7th International Conference on Practical Applications of Computational Biology & Bioinformatics. Advances in Intelligent Systems and Computing, vol 222. Springer, Heidelberg. https://doi.org/10.1007/978-3-319-00578-2_5
9783319005775
2194-5357
2194-5365
10.1007/978-3-319-00578-2_5
https://link.springer.com/chapter/10.1007/978-3-319-00578-2_5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.mail.fl_str_mv mluisa.alvim@gmail.com
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