Sleep and neurochemical modulation by DZNep and GSK-J1: potential link with histone methylation status
| Autor(a) principal: | |
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| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/54294 |
Resumo: | Copyright © 2019 Murillo-Rodríguez, Arankowsky-Sandoval, Barros, Rocha, Yamamoto, Machado, Budde, Telles-Correia, Monteiro, Cid and Veras. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Sleep and neurochemical modulation by DZNep and GSK-J1: potential link with histone methylation statusAdenosineDopamineHistone demethylationSerotoninSleepWakefulnessCopyright © 2019 Murillo-Rodríguez, Arankowsky-Sandoval, Barros, Rocha, Yamamoto, Machado, Budde, Telles-Correia, Monteiro, Cid and Veras. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Histone methylation/demethylation plays an important modulatory role in chromatin restructuring, RNA transcription and is essential for controlling a plethora of biological processes. Due to many human diseases have been related to histone methylation/demethylation, several compounds such as 3-deazaneplanocin A (DZNep) or 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid; N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-Alanine (GSK-J1), have been designed to inhibit histone methylase or suppress histone demethylase, respectively. In the present study, we investigated the effects on the sleep-wake cycle and sleep-related neurochemical levels after systemic injections of DZNep or GSK-J1 given during the light or dark phase in rats. DZNep dose-dependently (0.1, 1.0, or 10 mg/kg, i.p.) prolonged wakefulness (W) duration while decreased slow wave sleep (SWS) and rapid eye movement sleep (REMS) time spent during the lights-on period with no changes observed in dark phase. In opposite direction, GSK-J1 (0.1, 1.0, or 10 mg/kg, i.p.) injected at the beginning of the lights-on period induced no statistical changes in W, SWS, or REMS whereas if administered at darkness, we found a diminution in W and an enhancement in SWS and REMS. Finally, brain microdialysis experiments in freely moving animals were used to evaluate the effects of DZNep or GSK-J1 treatments on contents of sleep-related neurochemicals. The results showed that DZNep boosted extracellular levels of dopamine, norepinephrine, epinephrine, serotonin, adenosine, and acetylcholine if injected at the beginning of the lights-on period whereas GSK-J1 exerted similar outcomes but when administered at darkness. In summary, DZNep and GSK-J1 may control the sleep-wake cycle and sleep-related neurochemicals through histone methylation/demethylation activity.This work was supported by The University of California Institute for Mexico and the United States (UC MEXUS) and Consejo Nacional de Ciencia y Tecnología (CONACyT; Grant# CN-17-19) and Escuela de Medicina, Universidad Anáhuac Mayab (Grant: PresInvEMR2017) given to EM-R.FrontiersRepositório da Universidade de LisboaMurillo-Rodríguez, EricArankowsky-Sandoval, GloriaBarros, Jorge AparecidoRocha, Nuno BarbosaYamamoto, TetsuyaMachado, SérgioBudde, HenningTelles-Correia, DiogoMonteiro, DiogoCid, LuisVeras, André Barciela2022-09-05T13:07:57Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54294engFront Neurosci. 2019 Mar 15;13:2371662-454810.3389/fnins.2019.002371662-453Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:59:52Zoai:repositorio.ul.pt:10451/54294Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:04:43.739306Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Sleep and neurochemical modulation by DZNep and GSK-J1: potential link with histone methylation status |
| title |
Sleep and neurochemical modulation by DZNep and GSK-J1: potential link with histone methylation status |
| spellingShingle |
Sleep and neurochemical modulation by DZNep and GSK-J1: potential link with histone methylation status Murillo-Rodríguez, Eric Adenosine Dopamine Histone demethylation Serotonin Sleep Wakefulness |
| title_short |
Sleep and neurochemical modulation by DZNep and GSK-J1: potential link with histone methylation status |
| title_full |
Sleep and neurochemical modulation by DZNep and GSK-J1: potential link with histone methylation status |
| title_fullStr |
Sleep and neurochemical modulation by DZNep and GSK-J1: potential link with histone methylation status |
| title_full_unstemmed |
Sleep and neurochemical modulation by DZNep and GSK-J1: potential link with histone methylation status |
| title_sort |
Sleep and neurochemical modulation by DZNep and GSK-J1: potential link with histone methylation status |
| author |
Murillo-Rodríguez, Eric |
| author_facet |
Murillo-Rodríguez, Eric Arankowsky-Sandoval, Gloria Barros, Jorge Aparecido Rocha, Nuno Barbosa Yamamoto, Tetsuya Machado, Sérgio Budde, Henning Telles-Correia, Diogo Monteiro, Diogo Cid, Luis Veras, André Barciela |
| author_role |
author |
| author2 |
Arankowsky-Sandoval, Gloria Barros, Jorge Aparecido Rocha, Nuno Barbosa Yamamoto, Tetsuya Machado, Sérgio Budde, Henning Telles-Correia, Diogo Monteiro, Diogo Cid, Luis Veras, André Barciela |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Murillo-Rodríguez, Eric Arankowsky-Sandoval, Gloria Barros, Jorge Aparecido Rocha, Nuno Barbosa Yamamoto, Tetsuya Machado, Sérgio Budde, Henning Telles-Correia, Diogo Monteiro, Diogo Cid, Luis Veras, André Barciela |
| dc.subject.por.fl_str_mv |
Adenosine Dopamine Histone demethylation Serotonin Sleep Wakefulness |
| topic |
Adenosine Dopamine Histone demethylation Serotonin Sleep Wakefulness |
| description |
Copyright © 2019 Murillo-Rodríguez, Arankowsky-Sandoval, Barros, Rocha, Yamamoto, Machado, Budde, Telles-Correia, Monteiro, Cid and Veras. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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2019 |
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2019 2019-01-01T00:00:00Z 2022-09-05T13:07:57Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/54294 |
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http://hdl.handle.net/10451/54294 |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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Front Neurosci. 2019 Mar 15;13:237 1662-4548 10.3389/fnins.2019.00237 1662-453X |
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openAccess |
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Frontiers |
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Frontiers |
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