Designing improved active peptides for therapeutic approaches against infectious diseases

Detalhes bibliográficos
Autor(a) principal: Gomes, Bárbara
Data de Publicação: 2018
Outros Autores: Augusto, Marcelo T., Felício, Mário Romão, Hollmann, Axel, Franco, Octávio L., Abreu, Sónia Gonçalves, Santos, Nuno C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/37677
Resumo: © 2018 Elsevier Inc. All rights reserved.
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spelling Designing improved active peptides for therapeutic approaches against infectious diseasesBiologically active peptidesAntimicrobial peptidesAntiviral peptidesCell-penetrating peptidesPeptide-based drugs© 2018 Elsevier Inc. All rights reserved.Infectious diseases are one of the main causes of human morbidity and mortality. In the last few decades, pathogenic microorganisms' resistance to conventional drugs has been increasing, and it is now pinpointed as a major worldwide health concern. The need to search for new therapeutic options, as well as improved treatment outcomes, has therefore increased significantly, with biologically active peptides representing a new alternative. A substantial research effort is being dedicated towards their development, especially due to improved biocompatibility and target selectivity. However, the inherent limitations of peptide drugs are restricting their application. In this review, we summarize the current status of peptide drug development, focusing on antiviral and antimicrobial peptide activities, highlighting the design improvements needed, and those already being used, to overcome the drawbacks of the therapeutic application of biologically active peptides.This work was supported by Fundação para a Ciência e a Tecnologia – Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal) project PTDC/BBB-BQB/3494/2014, by Marie SkłodowskaCurie Research and Innovation Staff Exchange (MSCA-RISE, European Union) project INPACT (call H2020-MSCA-RISE-2014, grant agreement 644167), by the Brazilian funding agencies Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo a Pesquisa do Distrito Federal (FAPDF) and by Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT). BG, MA and MF acknowledge FCT-MCTES fellowships SPRH/BD/ 52431/2013, SPRH/BD/95624/2013 and SPRH/BD/100517/2014, respectively.ElsevierRepositório da Universidade de LisboaGomes, BárbaraAugusto, Marcelo T.Felício, Mário RomãoHollmann, AxelFranco, Octávio L.Abreu, Sónia GonçalvesSantos, Nuno C.2019-03-25T12:16:45Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10451/37677engBiotechnology Advances 36 (2018) 415–4290734-975010.1016/j.biotechadv.2018.01.004info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:34:56Zoai:repositorio.ul.pt:10451/37677Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:51:40.825755Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Designing improved active peptides for therapeutic approaches against infectious diseases
title Designing improved active peptides for therapeutic approaches against infectious diseases
spellingShingle Designing improved active peptides for therapeutic approaches against infectious diseases
Gomes, Bárbara
Biologically active peptides
Antimicrobial peptides
Antiviral peptides
Cell-penetrating peptides
Peptide-based drugs
title_short Designing improved active peptides for therapeutic approaches against infectious diseases
title_full Designing improved active peptides for therapeutic approaches against infectious diseases
title_fullStr Designing improved active peptides for therapeutic approaches against infectious diseases
title_full_unstemmed Designing improved active peptides for therapeutic approaches against infectious diseases
title_sort Designing improved active peptides for therapeutic approaches against infectious diseases
author Gomes, Bárbara
author_facet Gomes, Bárbara
Augusto, Marcelo T.
Felício, Mário Romão
Hollmann, Axel
Franco, Octávio L.
Abreu, Sónia Gonçalves
Santos, Nuno C.
author_role author
author2 Augusto, Marcelo T.
Felício, Mário Romão
Hollmann, Axel
Franco, Octávio L.
Abreu, Sónia Gonçalves
Santos, Nuno C.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gomes, Bárbara
Augusto, Marcelo T.
Felício, Mário Romão
Hollmann, Axel
Franco, Octávio L.
Abreu, Sónia Gonçalves
Santos, Nuno C.
dc.subject.por.fl_str_mv Biologically active peptides
Antimicrobial peptides
Antiviral peptides
Cell-penetrating peptides
Peptide-based drugs
topic Biologically active peptides
Antimicrobial peptides
Antiviral peptides
Cell-penetrating peptides
Peptide-based drugs
description © 2018 Elsevier Inc. All rights reserved.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2019-03-25T12:16:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/37677
url http://hdl.handle.net/10451/37677
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biotechnology Advances 36 (2018) 415–429
0734-9750
10.1016/j.biotechadv.2018.01.004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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