A systematic review of the development and application of home cage monitoring in laboratory mice and rats
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/160667 |
Resumo: | Funding Information: Open Access funding enabled and organized by Projekt DEAL. VV is supported by Jane and Aatos Erkko Foundation. Funding Information: The Vienna BioCenter Core Facilities (VBCF) Preclinical Phenotyping Facility acknowledges funding from the Austrian Federal Ministry of Education, Science & Research; and the City of Vienna. Funding Information: This article is based upon work from COST Action “Improving biomedical research by automated behaviour monitoring in the animal home-cage” (TEATIME; CA20135; cost-teatime.org) supported by COST (European Cooperation in Science and Technology). Funding Information: PK, PM, AJ, BL, CTR, LL, and KH were funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy—EXC 2002/1 “Science of Intelligence” —project number 390523135. Funding Information: This article is based upon work from COST Action “Improving biomedical research by automated behaviour monitoring in the animal home-cage” (TEATIME; CA20135; cost-teatime.org) supported by COST (European Cooperation in Science and Technology). Publisher Copyright: © 2023, The Author(s). |
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A systematic review of the development and application of home cage monitoring in laboratory mice and ratsAnimal welfareBehaviorHistoryHome cage monitoringMicePhysiologyRatsRefinementRodentsSex biasBiotechnologyStructural BiologyEcology, Evolution, Behavior and SystematicsPhysiologyBiochemistry, Genetics and Molecular Biology(all)Agricultural and Biological Sciences(all)Plant ScienceDevelopmental BiologyCell BiologyFunding Information: Open Access funding enabled and organized by Projekt DEAL. VV is supported by Jane and Aatos Erkko Foundation. Funding Information: The Vienna BioCenter Core Facilities (VBCF) Preclinical Phenotyping Facility acknowledges funding from the Austrian Federal Ministry of Education, Science & Research; and the City of Vienna. Funding Information: This article is based upon work from COST Action “Improving biomedical research by automated behaviour monitoring in the animal home-cage” (TEATIME; CA20135; cost-teatime.org) supported by COST (European Cooperation in Science and Technology). Funding Information: PK, PM, AJ, BL, CTR, LL, and KH were funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy—EXC 2002/1 “Science of Intelligence” —project number 390523135. Funding Information: This article is based upon work from COST Action “Improving biomedical research by automated behaviour monitoring in the animal home-cage” (TEATIME; CA20135; cost-teatime.org) supported by COST (European Cooperation in Science and Technology). Publisher Copyright: © 2023, The Author(s).Background: Traditionally, in biomedical animal research, laboratory rodents are individually examined in test apparatuses outside of their home cages at selected time points. However, the outcome of such tests can be influenced by various factors and valuable information may be missed when the animals are only monitored for short periods. These issues can be overcome by longitudinally monitoring mice and rats in their home cages. To shed light on the development of home cage monitoring (HCM) and the current state-of-the-art, a systematic review was carried out on 521 publications retrieved through PubMed and Web of Science. Results: Both the absolute (~ × 26) and relative (~ × 7) number of HCM-related publications increased from 1974 to 2020. There was a clear bias towards males and individually housed animals, but during the past decade (2011–2020), an increasing number of studies used both sexes and group housing. In most studies, animals were kept for short (up to 4 weeks) time periods in the HCM systems; intermediate time periods (4–12 weeks) increased in frequency in the years between 2011 and 2020. Before the 2000s, HCM techniques were predominantly applied for less than 12 h, while 24-h measurements have been more frequent since the 2000s. The systematic review demonstrated that manual monitoring is decreasing in relation to automatic techniques but still relevant. Until (and including) the 1990s, most techniques were applied manually but have been progressively replaced by automation since the 2000s. Independent of the year of publication, the main behavioral parameters measured were locomotor activity, feeding, and social behaviors; the main physiological parameters were heart rate and electrocardiography. External appearance-related parameters were rarely examined in the home cages. Due to technological progress and application of artificial intelligence, more refined and detailed behavioral parameters have been investigated in the home cage more recently. Conclusions: Over the period covered in this study, techniques for HCM of mice and rats have improved considerably. This development is ongoing and further progress as well as validation of HCM systems will extend the applications to allow for continuous, longitudinal, non-invasive monitoring of an increasing range of parameters in group-housed small rodents in their home cages.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSRUNKahnau, PiaMieske, PaulWilzopolski, JennyKalliokoski, OttoMandillo, SilviaHölter, Sabine M.Voikar, VooteleAmfim, AdrianaBadurek, SylviaBartelik, AleksandraCaruso, AngelaČater, MašaEy, ElodieGolini, ElisabettaJaap, AnneHrncic, DraganKiryk, AnnaLang, BenjaminLoncarevic-Vasiljkovic, NatasaMeziane, HamidRadzevičienė, AurelijaRivalan, MarionScattoni, Maria LuisaTorquet, NicolasTrifkovic, JulijanaUlfhake, BrunThöne-Reineke, ChristaDiederich, KaiLewejohann, LarsHohlbaum, Katharina2023-11-28T22:37:27Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/160667eng1741-7007PURE: 76624514https://doi.org/10.1186/s12915-023-01751-7info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:43:24Zoai:run.unl.pt:10362/160667Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:58:09.813267Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
A systematic review of the development and application of home cage monitoring in laboratory mice and rats |
| title |
A systematic review of the development and application of home cage monitoring in laboratory mice and rats |
| spellingShingle |
A systematic review of the development and application of home cage monitoring in laboratory mice and rats Kahnau, Pia Animal welfare Behavior History Home cage monitoring Mice Physiology Rats Refinement Rodents Sex bias Biotechnology Structural Biology Ecology, Evolution, Behavior and Systematics Physiology Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Plant Science Developmental Biology Cell Biology |
| title_short |
A systematic review of the development and application of home cage monitoring in laboratory mice and rats |
| title_full |
A systematic review of the development and application of home cage monitoring in laboratory mice and rats |
| title_fullStr |
A systematic review of the development and application of home cage monitoring in laboratory mice and rats |
| title_full_unstemmed |
A systematic review of the development and application of home cage monitoring in laboratory mice and rats |
| title_sort |
A systematic review of the development and application of home cage monitoring in laboratory mice and rats |
| author |
Kahnau, Pia |
| author_facet |
Kahnau, Pia Mieske, Paul Wilzopolski, Jenny Kalliokoski, Otto Mandillo, Silvia Hölter, Sabine M. Voikar, Vootele Amfim, Adriana Badurek, Sylvia Bartelik, Aleksandra Caruso, Angela Čater, Maša Ey, Elodie Golini, Elisabetta Jaap, Anne Hrncic, Dragan Kiryk, Anna Lang, Benjamin Loncarevic-Vasiljkovic, Natasa Meziane, Hamid Radzevičienė, Aurelija Rivalan, Marion Scattoni, Maria Luisa Torquet, Nicolas Trifkovic, Julijana Ulfhake, Brun Thöne-Reineke, Christa Diederich, Kai Lewejohann, Lars Hohlbaum, Katharina |
| author_role |
author |
| author2 |
Mieske, Paul Wilzopolski, Jenny Kalliokoski, Otto Mandillo, Silvia Hölter, Sabine M. Voikar, Vootele Amfim, Adriana Badurek, Sylvia Bartelik, Aleksandra Caruso, Angela Čater, Maša Ey, Elodie Golini, Elisabetta Jaap, Anne Hrncic, Dragan Kiryk, Anna Lang, Benjamin Loncarevic-Vasiljkovic, Natasa Meziane, Hamid Radzevičienė, Aurelija Rivalan, Marion Scattoni, Maria Luisa Torquet, Nicolas Trifkovic, Julijana Ulfhake, Brun Thöne-Reineke, Christa Diederich, Kai Lewejohann, Lars Hohlbaum, Katharina |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) iNOVA4Health - pólo NMS RUN |
| dc.contributor.author.fl_str_mv |
Kahnau, Pia Mieske, Paul Wilzopolski, Jenny Kalliokoski, Otto Mandillo, Silvia Hölter, Sabine M. Voikar, Vootele Amfim, Adriana Badurek, Sylvia Bartelik, Aleksandra Caruso, Angela Čater, Maša Ey, Elodie Golini, Elisabetta Jaap, Anne Hrncic, Dragan Kiryk, Anna Lang, Benjamin Loncarevic-Vasiljkovic, Natasa Meziane, Hamid Radzevičienė, Aurelija Rivalan, Marion Scattoni, Maria Luisa Torquet, Nicolas Trifkovic, Julijana Ulfhake, Brun Thöne-Reineke, Christa Diederich, Kai Lewejohann, Lars Hohlbaum, Katharina |
| dc.subject.por.fl_str_mv |
Animal welfare Behavior History Home cage monitoring Mice Physiology Rats Refinement Rodents Sex bias Biotechnology Structural Biology Ecology, Evolution, Behavior and Systematics Physiology Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Plant Science Developmental Biology Cell Biology |
| topic |
Animal welfare Behavior History Home cage monitoring Mice Physiology Rats Refinement Rodents Sex bias Biotechnology Structural Biology Ecology, Evolution, Behavior and Systematics Physiology Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Plant Science Developmental Biology Cell Biology |
| description |
Funding Information: Open Access funding enabled and organized by Projekt DEAL. VV is supported by Jane and Aatos Erkko Foundation. Funding Information: The Vienna BioCenter Core Facilities (VBCF) Preclinical Phenotyping Facility acknowledges funding from the Austrian Federal Ministry of Education, Science & Research; and the City of Vienna. Funding Information: This article is based upon work from COST Action “Improving biomedical research by automated behaviour monitoring in the animal home-cage” (TEATIME; CA20135; cost-teatime.org) supported by COST (European Cooperation in Science and Technology). Funding Information: PK, PM, AJ, BL, CTR, LL, and KH were funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy—EXC 2002/1 “Science of Intelligence” —project number 390523135. Funding Information: This article is based upon work from COST Action “Improving biomedical research by automated behaviour monitoring in the animal home-cage” (TEATIME; CA20135; cost-teatime.org) supported by COST (European Cooperation in Science and Technology). Publisher Copyright: © 2023, The Author(s). |
| publishDate |
2023 |
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2023-11-28T22:37:27Z 2023-12 2023-12-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/160667 |
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http://hdl.handle.net/10362/160667 |
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eng |
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eng |
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1741-7007 PURE: 76624514 https://doi.org/10.1186/s12915-023-01751-7 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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