Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Aurélie Pinto
Data de Publicação: 2014
Outros Autores: Santos, Lúcia, Oliva-Teles, Maria Teresa, Delerue-Matos, Cristina, Guimarães, Laura
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/5329
Resumo: Concurrent exposure of estuarine organisms to man-made and natural stressors has become a common occurrence. Numerous interactions of multiple stressors causing synergistic or antagonistic effects have been described. However, limited information is available on combined effects of emerging pharmaceuticals and natural stressors. This study investigated the joint effects of the antidepressant sertraline and salinity on Carcinus maenas. To improve knowledge about interactive effects and potential vulnerability,experiments were performed with organisms from two estuaries with differing histories of exposure to environmental contamination. Biomarkers related to mode of action of sertraline were employed to assess effects of environmentally realistic concentrations of sertraline at two salinity levels. Synergism and antagonism were identified for biomarkers of cholinergic neurotransmission, energy production,anti-oxidant defences and oxidative damage. Different interactions were found for the two study sites highlighting the need to account for differences in tolerance of local ecological receptors in risk evaluations.
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spelling Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenasSertralineSalinityInteractive effectsAcetylcholinesteraseOxidative damageConcurrent exposure of estuarine organisms to man-made and natural stressors has become a common occurrence. Numerous interactions of multiple stressors causing synergistic or antagonistic effects have been described. However, limited information is available on combined effects of emerging pharmaceuticals and natural stressors. This study investigated the joint effects of the antidepressant sertraline and salinity on Carcinus maenas. To improve knowledge about interactive effects and potential vulnerability,experiments were performed with organisms from two estuaries with differing histories of exposure to environmental contamination. Biomarkers related to mode of action of sertraline were employed to assess effects of environmentally realistic concentrations of sertraline at two salinity levels. Synergism and antagonism were identified for biomarkers of cholinergic neurotransmission, energy production,anti-oxidant defences and oxidative damage. Different interactions were found for the two study sites highlighting the need to account for differences in tolerance of local ecological receptors in risk evaluations.ElsevierRepositório Científico do Instituto Politécnico do PortoRodrigues, Aurélie PintoSantos, LúciaOliva-Teles, Maria TeresaDelerue-Matos, CristinaGuimarães, Laura2015-01-07T12:11:18Z2014-112014-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/5329eng10.1016/j.aquatox.2014.08.011metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:45:22Zoai:recipp.ipp.pt:10400.22/5329Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:25:59.781614Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas
title Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas
spellingShingle Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas
Rodrigues, Aurélie Pinto
Sertraline
Salinity
Interactive effects
Acetylcholinesterase
Oxidative damage
title_short Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas
title_full Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas
title_fullStr Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas
title_full_unstemmed Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas
title_sort Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas
author Rodrigues, Aurélie Pinto
author_facet Rodrigues, Aurélie Pinto
Santos, Lúcia
Oliva-Teles, Maria Teresa
Delerue-Matos, Cristina
Guimarães, Laura
author_role author
author2 Santos, Lúcia
Oliva-Teles, Maria Teresa
Delerue-Matos, Cristina
Guimarães, Laura
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Rodrigues, Aurélie Pinto
Santos, Lúcia
Oliva-Teles, Maria Teresa
Delerue-Matos, Cristina
Guimarães, Laura
dc.subject.por.fl_str_mv Sertraline
Salinity
Interactive effects
Acetylcholinesterase
Oxidative damage
topic Sertraline
Salinity
Interactive effects
Acetylcholinesterase
Oxidative damage
description Concurrent exposure of estuarine organisms to man-made and natural stressors has become a common occurrence. Numerous interactions of multiple stressors causing synergistic or antagonistic effects have been described. However, limited information is available on combined effects of emerging pharmaceuticals and natural stressors. This study investigated the joint effects of the antidepressant sertraline and salinity on Carcinus maenas. To improve knowledge about interactive effects and potential vulnerability,experiments were performed with organisms from two estuaries with differing histories of exposure to environmental contamination. Biomarkers related to mode of action of sertraline were employed to assess effects of environmentally realistic concentrations of sertraline at two salinity levels. Synergism and antagonism were identified for biomarkers of cholinergic neurotransmission, energy production,anti-oxidant defences and oxidative damage. Different interactions were found for the two study sites highlighting the need to account for differences in tolerance of local ecological receptors in risk evaluations.
publishDate 2014
dc.date.none.fl_str_mv 2014-11
2014-11-01T00:00:00Z
2015-01-07T12:11:18Z
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dc.relation.none.fl_str_mv 10.1016/j.aquatox.2014.08.011
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dc.publisher.none.fl_str_mv Elsevier
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