Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/5329 |
Resumo: | Concurrent exposure of estuarine organisms to man-made and natural stressors has become a common occurrence. Numerous interactions of multiple stressors causing synergistic or antagonistic effects have been described. However, limited information is available on combined effects of emerging pharmaceuticals and natural stressors. This study investigated the joint effects of the antidepressant sertraline and salinity on Carcinus maenas. To improve knowledge about interactive effects and potential vulnerability,experiments were performed with organisms from two estuaries with differing histories of exposure to environmental contamination. Biomarkers related to mode of action of sertraline were employed to assess effects of environmentally realistic concentrations of sertraline at two salinity levels. Synergism and antagonism were identified for biomarkers of cholinergic neurotransmission, energy production,anti-oxidant defences and oxidative damage. Different interactions were found for the two study sites highlighting the need to account for differences in tolerance of local ecological receptors in risk evaluations. |
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Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenasSertralineSalinityInteractive effectsAcetylcholinesteraseOxidative damageConcurrent exposure of estuarine organisms to man-made and natural stressors has become a common occurrence. Numerous interactions of multiple stressors causing synergistic or antagonistic effects have been described. However, limited information is available on combined effects of emerging pharmaceuticals and natural stressors. This study investigated the joint effects of the antidepressant sertraline and salinity on Carcinus maenas. To improve knowledge about interactive effects and potential vulnerability,experiments were performed with organisms from two estuaries with differing histories of exposure to environmental contamination. Biomarkers related to mode of action of sertraline were employed to assess effects of environmentally realistic concentrations of sertraline at two salinity levels. Synergism and antagonism were identified for biomarkers of cholinergic neurotransmission, energy production,anti-oxidant defences and oxidative damage. Different interactions were found for the two study sites highlighting the need to account for differences in tolerance of local ecological receptors in risk evaluations.ElsevierRepositório Científico do Instituto Politécnico do PortoRodrigues, Aurélie PintoSantos, LúciaOliva-Teles, Maria TeresaDelerue-Matos, CristinaGuimarães, Laura2015-01-07T12:11:18Z2014-112014-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/5329eng10.1016/j.aquatox.2014.08.011metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:45:22Zoai:recipp.ipp.pt:10400.22/5329Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:25:59.781614Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas |
title |
Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas |
spellingShingle |
Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas Rodrigues, Aurélie Pinto Sertraline Salinity Interactive effects Acetylcholinesterase Oxidative damage |
title_short |
Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas |
title_full |
Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas |
title_fullStr |
Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas |
title_full_unstemmed |
Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas |
title_sort |
Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas |
author |
Rodrigues, Aurélie Pinto |
author_facet |
Rodrigues, Aurélie Pinto Santos, Lúcia Oliva-Teles, Maria Teresa Delerue-Matos, Cristina Guimarães, Laura |
author_role |
author |
author2 |
Santos, Lúcia Oliva-Teles, Maria Teresa Delerue-Matos, Cristina Guimarães, Laura |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Rodrigues, Aurélie Pinto Santos, Lúcia Oliva-Teles, Maria Teresa Delerue-Matos, Cristina Guimarães, Laura |
dc.subject.por.fl_str_mv |
Sertraline Salinity Interactive effects Acetylcholinesterase Oxidative damage |
topic |
Sertraline Salinity Interactive effects Acetylcholinesterase Oxidative damage |
description |
Concurrent exposure of estuarine organisms to man-made and natural stressors has become a common occurrence. Numerous interactions of multiple stressors causing synergistic or antagonistic effects have been described. However, limited information is available on combined effects of emerging pharmaceuticals and natural stressors. This study investigated the joint effects of the antidepressant sertraline and salinity on Carcinus maenas. To improve knowledge about interactive effects and potential vulnerability,experiments were performed with organisms from two estuaries with differing histories of exposure to environmental contamination. Biomarkers related to mode of action of sertraline were employed to assess effects of environmentally realistic concentrations of sertraline at two salinity levels. Synergism and antagonism were identified for biomarkers of cholinergic neurotransmission, energy production,anti-oxidant defences and oxidative damage. Different interactions were found for the two study sites highlighting the need to account for differences in tolerance of local ecological receptors in risk evaluations. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-11 2014-11-01T00:00:00Z 2015-01-07T12:11:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/5329 |
url |
http://hdl.handle.net/10400.22/5329 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.aquatox.2014.08.011 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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