Seroconversion Rate Following HBV Vaccination in Clinical Practice: The Role of Age and DMT Treatment
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/4370 |
Resumo: | HBV screening and immunization is recommended in all MS patients and is mandatory before the start of some DMT. However, studies evaluating the immune response to HBV vaccine in MS patients are scarce. We aimed to evaluate the seroprotection rate following HBV immunization in MS patients and to assess if older age and DMT-treatment influenced seroprotection. We conducted a cohort study between 2016 and 2020 and compared the immune response to HBV vaccine in MS patients under different DMTs and in patients 50 years old or younger and older than 50. We found that patients under non-injectable DMT presented lower rates of seroprotection comparing to patients under injectable DMT's or without treatment. In patients older than 50, although the seroprotection rate was similar to the remaining patients, the antibody anti-HBV surface antigen titers following HBV immunization were lower and patients were more likely to require a 4th dose of the vaccine to achieve seroprotection. Our findings highlight to need to consider HBV immunization in MS patients early in the disease course, in order to ensure a proper immune response to the vaccine. |
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Seroconversion Rate Following HBV Vaccination in Clinical Practice: The Role of Age and DMT TreatmentDMT/treatmentHBVMultiple SclerosisVaccineAgeingHSAC NEUHBV screening and immunization is recommended in all MS patients and is mandatory before the start of some DMT. However, studies evaluating the immune response to HBV vaccine in MS patients are scarce. We aimed to evaluate the seroprotection rate following HBV immunization in MS patients and to assess if older age and DMT-treatment influenced seroprotection. We conducted a cohort study between 2016 and 2020 and compared the immune response to HBV vaccine in MS patients under different DMTs and in patients 50 years old or younger and older than 50. We found that patients under non-injectable DMT presented lower rates of seroprotection comparing to patients under injectable DMT's or without treatment. In patients older than 50, although the seroprotection rate was similar to the remaining patients, the antibody anti-HBV surface antigen titers following HBV immunization were lower and patients were more likely to require a 4th dose of the vaccine to achieve seroprotection. Our findings highlight to need to consider HBV immunization in MS patients early in the disease course, in order to ensure a proper immune response to the vaccine.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEFaustino, PCoutinho, MLeitão, LCapela, CBrum, MParra, JSequeira, JBarros, AAraújo, CSousa, ALadeira, F2023-01-31T11:09:58Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4370engMult Scler Relat Disord . 2021 May;50:102859.10.1016/j.msard.2021.102859info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:46:17Zoai:repositorio.chlc.min-saude.pt:10400.17/4370Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:41.885329Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Seroconversion Rate Following HBV Vaccination in Clinical Practice: The Role of Age and DMT Treatment |
title |
Seroconversion Rate Following HBV Vaccination in Clinical Practice: The Role of Age and DMT Treatment |
spellingShingle |
Seroconversion Rate Following HBV Vaccination in Clinical Practice: The Role of Age and DMT Treatment Faustino, P DMT/treatment HBV Multiple Sclerosis Vaccine Ageing HSAC NEU |
title_short |
Seroconversion Rate Following HBV Vaccination in Clinical Practice: The Role of Age and DMT Treatment |
title_full |
Seroconversion Rate Following HBV Vaccination in Clinical Practice: The Role of Age and DMT Treatment |
title_fullStr |
Seroconversion Rate Following HBV Vaccination in Clinical Practice: The Role of Age and DMT Treatment |
title_full_unstemmed |
Seroconversion Rate Following HBV Vaccination in Clinical Practice: The Role of Age and DMT Treatment |
title_sort |
Seroconversion Rate Following HBV Vaccination in Clinical Practice: The Role of Age and DMT Treatment |
author |
Faustino, P |
author_facet |
Faustino, P Coutinho, M Leitão, L Capela, C Brum, M Parra, J Sequeira, J Barros, A Araújo, C Sousa, A Ladeira, F |
author_role |
author |
author2 |
Coutinho, M Leitão, L Capela, C Brum, M Parra, J Sequeira, J Barros, A Araújo, C Sousa, A Ladeira, F |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Faustino, P Coutinho, M Leitão, L Capela, C Brum, M Parra, J Sequeira, J Barros, A Araújo, C Sousa, A Ladeira, F |
dc.subject.por.fl_str_mv |
DMT/treatment HBV Multiple Sclerosis Vaccine Ageing HSAC NEU |
topic |
DMT/treatment HBV Multiple Sclerosis Vaccine Ageing HSAC NEU |
description |
HBV screening and immunization is recommended in all MS patients and is mandatory before the start of some DMT. However, studies evaluating the immune response to HBV vaccine in MS patients are scarce. We aimed to evaluate the seroprotection rate following HBV immunization in MS patients and to assess if older age and DMT-treatment influenced seroprotection. We conducted a cohort study between 2016 and 2020 and compared the immune response to HBV vaccine in MS patients under different DMTs and in patients 50 years old or younger and older than 50. We found that patients under non-injectable DMT presented lower rates of seroprotection comparing to patients under injectable DMT's or without treatment. In patients older than 50, although the seroprotection rate was similar to the remaining patients, the antibody anti-HBV surface antigen titers following HBV immunization were lower and patients were more likely to require a 4th dose of the vaccine to achieve seroprotection. Our findings highlight to need to consider HBV immunization in MS patients early in the disease course, in order to ensure a proper immune response to the vaccine. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2023-01-31T11:09:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/4370 |
url |
http://hdl.handle.net/10400.17/4370 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mult Scler Relat Disord . 2021 May;50:102859. 10.1016/j.msard.2021.102859 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799131311891283968 |